Literature DB >> 24394494

Enzyme-triggered gelation: targeting proteases with internal cleavage sites.

Steven C Bremmer1, Anne J McNeil, Matthew B Soellner.   

Abstract

A generalizable method for detecting protease activity via gelation is described. A recognition sequence is used to target the protease of interest while a second protease is used to remove the residual residues from the gelator scaffold. Using this approach, selective assays for both MMP-9 and PSA are demonstrated.

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Year:  2014        PMID： 24394494      PMCID： PMC4143987          DOI： 10.1039/c3cc48132h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  35 in total

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3.  Enzyme-Instructed Self-Assembly of Peptides Containing Phosphoserine to Form Supramolecular Hydrogels as Potential Soft Biomaterials.

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8.  Gd(III)-induced Supramolecular Hydrogelation with Enhanced Magnetic Resonance Performance for Enzyme Detection.

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Review 9.  Engineering responsive supramolecular biomaterials: Toward smart therapeutics.

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10.  Dual functional matrix metalloproteinase-responsive curcumin-loaded nanoparticles for tumor-targeted treatment.

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