BACKGROUND AND OBJECTIVES: Low-serum vitamin D levels have been associated with increased cardiovascular risk in the general population. We hypothesized that serum vitamin D levels would be inversely associated with inflammation and with severity of coronary atherosclerosis. We therefore investigated the link between serum vitamin D levels and (1) the extent of coronary artery disease (CAD) assessed by the Gensini score and (2) inflammatory parameters, including C-reactive protein and fibrinogen. MATERIALS AND METHODS: We measured 25-hydroxyvitamin D (25[OH]D) and inflammatory markers in 239 patients who underwent coronary angiography. We analyzed the relation between serum levels of 25(OH)D and inflammatory markers and angiographic severity of CAD. The Gensini lesion severity score was used for assessing the severity of coronary atherosclerosis. RESULTS: Vitamin D insufficiency was very common among our study population: 83% of the study population had levels less than 30 ng/mL. The Gensini score was negatively associated with serum vitamin D levels (r = -0.416, P < 0.001), and positively correlated with age (r = 0.209, P = 0.001), blood pressure (r = 0.379, P < 0.001), diabetes (r = 0.335, P < 0.001), hyperlipidemia (r = 0.150, P = 0,021), and C-reactive protein levels (r = 0.214, P = 0,001). After adjustments for traditional and nontraditional cardiovascular risk factors, vitamin D (B = -0,345, P < 0,001) remained a significant predictor for the severity of CAD. CONCLUSIONS: Low-serum 25(OH)D levels are associated with the severity of coronary artery stenosis. Further studies are warranted to determine whether vitamin D supplementation could prevent progression of CAD.
BACKGROUND AND OBJECTIVES: Low-serum vitamin D levels have been associated with increased cardiovascular risk in the general population. We hypothesized that serum vitamin D levels would be inversely associated with inflammation and with severity of coronary atherosclerosis. We therefore investigated the link between serum vitamin D levels and (1) the extent of coronary artery disease (CAD) assessed by the Gensini score and (2) inflammatory parameters, including C-reactive protein and fibrinogen. MATERIALS AND METHODS: We measured 25-hydroxyvitamin D (25[OH]D) and inflammatory markers in 239 patients who underwent coronary angiography. We analyzed the relation between serum levels of 25(OH)D and inflammatory markers and angiographic severity of CAD. The Gensini lesion severity score was used for assessing the severity of coronary atherosclerosis. RESULTS:Vitamin Dinsufficiency was very common among our study population: 83% of the study population had levels less than 30 ng/mL. The Gensini score was negatively associated with serum vitamin D levels (r = -0.416, P < 0.001), and positively correlated with age (r = 0.209, P = 0.001), blood pressure (r = 0.379, P < 0.001), diabetes (r = 0.335, P < 0.001), hyperlipidemia (r = 0.150, P = 0,021), and C-reactive protein levels (r = 0.214, P = 0,001). After adjustments for traditional and nontraditional cardiovascular risk factors, vitamin D (B = -0,345, P < 0,001) remained a significant predictor for the severity of CAD. CONCLUSIONS: Low-serum 25(OH)D levels are associated with the severity of coronary artery stenosis. Further studies are warranted to determine whether vitamin D supplementation could prevent progression of CAD.
Authors: Paulette D Chandler; Jamil B Scott; Bettina F Drake; Kimmie Ng; Joann E Manson; Nader Rifai; Andrew T Chan; Gary G Bennett; Bruce W Hollis; Edward L Giovannucci; Karen M Emmons; Charles S Fuchs Journal: Cancer Prev Res (Phila) Date: 2013-12-10
Authors: Apinya Lertratanakul; Peggy Wu; Alan Dyer; Murray Urowitz; Dafna Gladman; Paul Fortin; Sang-Cheol Bae; Caroline Gordon; Ann Clarke; Sasha Bernatsky; John G Hanly; David Isenberg; Anisur Rahman; Joan Merrill; Daniel J Wallace; Ellen Ginzler; Munther Khamashta; Ian Bruce; Ola Nived; Gunnar Sturfelt; Kristjan Steinsson; Susan Manzi; Mary Anne Dooley; Kenneth Kalunian; Michelle Petri; Cynthia Aranow; Josep Font; Ronald van Vollenhoven; Thomas Stoll; Rosalind Ramsey-Goldman Journal: Arthritis Care Res (Hoboken) Date: 2014-08 Impact factor: 4.794
Authors: Christine Chew; John A Reynolds; Apinya Lertratanakul; Peggy Wu; Murray Urowitz; Dafna D Gladman; Paul R Fortin; Sang-Cheol Bae; Caroline Gordon; Ann E Clarke; Sasha Bernatsky; John G Hanly; David Isenberg; Anisur Rahman; Jorge Sanchez-Guerrero; Juanita Romero-Diaz; Joan Merrill; Daniel Wallace; Ellen Ginzler; Munther Khamashta; Ola Nived; Andreas Jönsen; Kristjan Steinsson; Susan Manzi; Ken Kalunian; Mary Anne Dooley; Michelle Petri; Cynthia Aranow; Ronald van Vollenhoven; Thomas Stoll; Graciela S Alarcón; S Sam Lim; Guillermo Ruiz-Irastorza; Christine A Peschken; Anca D Askanase; Diane L Kamen; Murat İnanç; Rosalind Ramsey-Goldman; Ian N Bruce Journal: Rheumatology (Oxford) Date: 2021-10-02 Impact factor: 7.580