| Literature DB >> 2253401 |
Abstract
The effect of oral contraceptives and of pregnancy on the daily rhythm of cortisol, and its metabolite cortisone in plasma and saliva has been investigated. In both conditions the total plasma cortisol levels were raised to the same extent, the mean values in saliva in the oral contraceptive users being intermediate between those in pregnancy and in the controls, particularly in the morning. Salivary cortisone levels were more related to salivary cortisol than to total plasma cortisone which exhibited a rather flat daily rhythm. There was a shift in peak values for salivary cortisol and cortisone towards late morning: this may be due to a delay in the daily activation of the hypothalamic-pituitary-adrenal axis in these patients.Entities:
Keywords: Adrenal Cortex Hormones; Biology; Clinical Research; Contraception; Contraceptive Methods--pharmacodynamics; Endocrine System; Estrogens--pharmacodynamics; Family Planning; Hormones; Oral Contraceptives, Low-dose--pharmacodynamics; Oral Contraceptives--pharmacodynamics; Physiology; Pregnancy--pharmacodynamics; Reproduction; Research Methodology
Mesh：
Substances：
Year: 1990 PMID： 2253401 DOI： 10.1016/0009-8981(90)90175-r
Source DB: PubMed Journal: Clin Chim Acta ISSN： 0009-8981 Impact factor: 3.786