| Literature DB >> 35732898 |
José Antonio Monreal1,2, Neus Salvat-Pujol2,3,4,5, Alexandre González-Rodríguez1, Mikel Urretavizcaya2,3,4, José Manuel Crespo2,3,4, Roser Nadal2,6, Aida de Arriba-Arnau2,4, Clara Massaneda4, Diego Palao2,5, José Manuel Menchón2,3,4, Javier Labad2,7, Virginia Soria8,9,10.
Abstract
The aim of our study was to examine whether there are sex-based differences in the relationship between personality traits and hypothalamic-pituitary-adrenal (HPA) axis measures. A total of 106 healthy volunteers (56.6% women; age: 48.0 ± 15.8 years) were studied. The revised temperament and character inventory (TCI-R) and the Childhood Trauma Questionnaire (CTQ) were administered. HPA axis function was assessed using three dynamic measures: the cortisol awakening response (CAR), the diurnal cortisol slope, and the cortisol suppression ratio with 0.25 mg of dexamethasone (DSTR). Female sex was associated with an increased CAR and a more flattened diurnal cortisol slope, although a negative significant interaction between harm avoidance and female sex was found. Regarding the DSTR, perseverance was associated with increased cortisol suppression after dexamethasone; sex did not affect this association. Our study suggests that the relationship between specific personality traits (harm avoidance) and HPA axis measures (CAR, diurnal slope) differs according to sex.Entities:
Keywords: Cortisol; HPA; Harm avoidance; Personality; Sex differences
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Year: 2022 PMID： 35732898 DOI： 10.1007/s00737-022-01241-9
Source DB: PubMed Journal: Arch Womens Ment Health ISSN： 1434-1816 Impact factor: 4.405