Literature DB >> 22533875

Mitigating heterocycle metabolism in drug discovery.

David J St Jean1, Christopher Fotsch.   

Abstract

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Year:  2012        PMID： 22533875     DOI： 10.1021/jm300343m

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  28 in total

1.  Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.

Authors:  Ha T Do; Huiying Li; Georges Chreifi; Thomas L Poulos; Richard B Silverman
Journal:  J Med Chem       Date:  2019-02-25       Impact factor: 7.446

2.  Mastering tricyclic ring systems for desirable functional cannabinoid activity.

Authors:  Ravil R Petrov; Lindsay Knight; Shao-Rui Chen; Jim Wager-Miller; Steven W McDaniel; Fanny Diaz; Francis Barth; Hui-Lin Pan; Ken Mackie; Claudio N Cavasotto; Philippe Diaz
Journal:  Eur J Med Chem       Date:  2013-09-29       Impact factor: 6.514

Review 3.  Scaffold-hopping as a strategy to address metabolic liabilities of aromatic compounds.

Authors:  Phillip R Lazzara; Terry W Moore
Journal:  RSC Med Chem       Date:  2019-12-16

Review 4.  A review of salvinorin analogs and their kappa-opioid receptor activity.

Authors:  Jeremy J Roach; Ryan A Shenvi
Journal:  Bioorg Med Chem Lett       Date:  2018-03-12       Impact factor: 2.823

5.  Improved Cav2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide.

Authors:  Pengcheng P Shao; Feng Ye; Prasun K Chakravarty; James B Herrington; Ge Dai; Randal M Bugianesi; Rodolfo J Haedo; Andrew M Swensen; Vivien A Warren; McHardy M Smith; Maria L Garcia; Owen B McManus; Kathryn A Lyons; Xiaohua Li; Mitchell Green; Nina Jochnowitz; Erin McGowan; Shruti Mistry; Shu-Yu Sun; Catherine Abbadie; Gregory J Kaczorowski; Joseph L Duffy
Journal:  ACS Med Chem Lett       Date:  2013-09-08       Impact factor: 4.345

6.  Enantioselective Synthesis of Oxetanes Bearing All-Carbon Quaternary Stereocenters via Iridium-Catalyzed C-C Bond-Forming Transfer Hydrogenation.

Authors:  Yi-An Guo; Wonchul Lee; Michael J Krische
Journal:  Chemistry       Date:  2017-01-27       Impact factor: 5.236

7.  Multifaceted Substrate-Ligand Interactions Promote the Copper-Catalyzed Hydroboration of Benzylidenecyclobutanes and Related Compounds.

Authors:  Taeho Kang; Tuğçe G Erbay; Kane L Xu; Gary M Gallego; Alexander Burtea; Sajiv K Nair; Ryan L Patman; Ru Zhou; Scott C Sutton; Indrawan J McAlpine; Peng Liu; Keary M Engle
Journal:  ACS Catal       Date:  2020-10-27       Impact factor: 13.084

8.  Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi.

Authors:  Swapna Varghese; Raphaël Rahmani; Stephanie Russell; Girdhar Singh Deora; Lori Ferrins; Arthur Toynton; Amy Jones; Melissa Sykes; Albane Kessler; Amanda Eufrásio; Artur Torres Cordeiro; Julian Sherman; Ana Rodriguez; Vicky M Avery; Matthew J Piggott; Jonathan B Baell
Journal:  ACS Med Chem Lett       Date:  2019-09-09       Impact factor: 4.345

9.  Syntheses and anti-HIV and human cluster of differentiation 4 (CD4) down-modulating potencies of pyridine-fused cyclotriazadisulfonamide (CADA) compounds.

Authors:  Liezel A Lumangtad; Elisa Claeys; Sunil Hamal; Amarawan Intasiri; Courtney Basrai; Expedite Yen-Pon; Davison Beenfeldt; Kurt Vermeire; Thomas W Bell
Journal:  Bioorg Med Chem       Date:  2020-10-26       Impact factor: 3.641

10.  Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam.

Authors:  Dustyn A Barnette; Mary A Schleiff; Arghya Datta; Noah Flynn; S Joshua Swamidass; Grover P Miller
Journal:  Toxicol Lett       Date:  2020-11-27       Impact factor: 4.372
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