Literature DB >> 22530946

Intramolecular free-radical cyclization reactions on pentose sugars for the synthesis of carba-LNA and carba-ENA and the application of their modified oligonucleotides as potential RNA targeted therapeutics.

Chuanzheng Zhou1, Jyoti Chattopadhyaya.   

Abstract

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Year:  2012        PMID： 22530946     DOI： 10.1021/cr100306q

Source DB:  PubMed          Journal:  Chem Rev        ISSN： 0009-2665            Impact factor:   60.622


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  6 in total

1.  Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-amino-α-L-LNA adenine monomers: high-affinity targeting of single-stranded DNA.

Authors:  Nicolai K Andersen; Brooke A Anderson; Jesper Wengel; Patrick J Hrdlicka
Journal:  J Org Chem       Date:  2013-12-11       Impact factor: 4.354

2.  Synthesis, duplex stabilization and structural properties of a fluorinated carbocyclic LNA analogue.

Authors:  Punit P Seth; Pradeep S Pallan; Eric E Swayze; Martin Egli
Journal:  Chembiochem       Date:  2012-11-28       Impact factor: 3.164

3.  C5-alkynyl-functionalized α-L-LNA: synthesis, thermal denaturation experiments and enzymatic stability.

Authors:  Pawan Kumar; Bharat Baral; Brooke A Anderson; Dale C Guenther; Michael E Østergaard; Pawan K Sharma; Patrick J Hrdlicka
Journal:  J Org Chem       Date:  2014-05-13       Impact factor: 4.354

4.  Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals.

Authors:  Punit P Seth; Ali Jazayeri; Jeff Yu; Charles R Allerson; Balkrishen Bhat; Eric E Swayze
Journal:  Mol Ther Nucleic Acids       Date:  2012-09-18       Impact factor: 10.183

5.  Synthesis and biophysical properties of C5-functionalized LNA (locked nucleic acid).

Authors:  Pawan Kumar; Michael E Østergaard; Bharat Baral; Brooke A Anderson; Dale C Guenther; Mamta Kaura; Daniel J Raible; Pawan K Sharma; Patrick J Hrdlicka
Journal:  J Org Chem       Date:  2014-05-13       Impact factor: 4.354

6.  Synthesis of Oligonucleotides Containing 2'-N-alkylaminocarbonyl-2'-amino-LNA (2'-urea-LNA) Moieties Using Post-Synthetic Modification Strategy.

Authors:  Shoko Yamashita; Kodai Nishida; Takashi Osawa; Ayumi Nakanishi; Yuta Ito; Yoshiyuki Hari
Journal:  Molecules       Date:  2020-01-15       Impact factor: 4.411
  6 in total

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