OBJECTIVES: Convergent evidence supports limbic, anterior paralimbic, and prefrontal cortex (PFC) abnormalities in emotional processing in bipolar disorder (BD) and suggests that some abnormalities are mood-state dependent and others persist into euthymia. However, few studies have assessed elevated, depressed, and euthymic mood states while individuals processed emotional stimuli of varying valence to investigate trait- and state-related neural system responses. Here, regional brain responses to positive, negative, and neutral emotional stimuli were assessed in individuals with BD during elevated, depressed, and euthymic mood states. METHODS: One hundred and thirty-four subjects participated in functional magnetic resonance imaging scanning while processing faces depicting happy, fearful, and neutral expressions: 76 with BD (18 in elevated mood states, 19 depressed, 39 euthymic) and 58 healthy comparison (HC) individuals. Analyses were performed for BD trait- and mood state-related features. RESULTS: Ventral anterior cingulate cortex (VACC), orbitofrontal cortex (OFC), and ventral striatum responses to happy and neutral faces were decreased in the BD group, compared to the HC group, and were not influenced by mood state. Elevated mood states were associated with decreased right rostral PFC activation to fearful and neutral faces, and depression was associated with increased left OFC activation to fearful faces. CONCLUSIONS: The findings suggest that abnormal VACC, OFC, and ventral striatum responses to happy and neutral stimuli are trait features of BD. Acute mood states may be associated with additional lateralized abnormalities of diminished right rostral PFC responses to fearful and neutral stimuli in elevated states and increased left OFC responses to fearful stimuli in depressed states.
OBJECTIVES: Convergent evidence supports limbic, anterior paralimbic, and prefrontal cortex (PFC) abnormalities in emotional processing in bipolar disorder (BD) and suggests that some abnormalities are mood-state dependent and others persist into euthymia. However, few studies have assessed elevated, depressed, and euthymic mood states while individuals processed emotional stimuli of varying valence to investigate trait- and state-related neural system responses. Here, regional brain responses to positive, negative, and neutral emotional stimuli were assessed in individuals with BD during elevated, depressed, and euthymic mood states. METHODS: One hundred and thirty-four subjects participated in functional magnetic resonance imaging scanning while processing faces depicting happy, fearful, and neutral expressions: 76 with BD (18 in elevated mood states, 19 depressed, 39 euthymic) and 58 healthy comparison (HC) individuals. Analyses were performed for BD trait- and mood state-related features. RESULTS: Ventral anterior cingulate cortex (VACC), orbitofrontal cortex (OFC), and ventral striatum responses to happy and neutral faces were decreased in the BD group, compared to the HC group, and were not influenced by mood state. Elevated mood states were associated with decreased right rostral PFC activation to fearful and neutral faces, and depression was associated with increased left OFC activation to fearful faces. CONCLUSIONS: The findings suggest that abnormal VACC, OFC, and ventral striatum responses to happy and neutral stimuli are trait features of BD. Acute mood states may be associated with additional lateralized abnormalities of diminished right rostral PFC responses to fearful and neutral stimuli in elevated states and increased left OFC responses to fearful stimuli in depressed states.
Authors: Hilary P Blumberg; Nelson H Donegan; Charles A Sanislow; Susan Collins; Cheryl Lacadie; Pawel Skudlarski; Ralitza Gueorguieva; Robert K Fulbright; Thomas H McGlashan; John C Gore; John H Krystal Journal: Psychopharmacology (Berl) Date: 2005-10-26 Impact factor: 4.530
Authors: Hilary P Blumberg; John H Krystal; Ravi Bansal; Andrés Martin; James Dziura; Kathleen Durkin; Laura Martin; Elizabeth Gerard; Dennis S Charney; Bradley S Peterson Journal: Biol Psychiatry Date: 2006-01-18 Impact factor: 13.382
Authors: Christopher S Monk; Rachel G Klein; Eva H Telzer; Elizabeth A Schroth; Salvatore Mannuzza; John L Moulton; Mary Guardino; Carrie L Masten; Erin B McClure-Tone; Stephen Fromm; R James Blair; Daniel S Pine; Monique Ernst Journal: Am J Psychiatry Date: 2007-11-06 Impact factor: 18.112
Authors: John O Brooks; Po W Wang; Julie C Bonner; Allyson C Rosen; Jennifer C Hoblyn; Shelley J Hill; Terence A Ketter Journal: J Psychiatr Res Date: 2008-06-25 Impact factor: 4.791
Authors: Pablo Najt; Fei Wang; Linda Spencer; Jennifer A Y Johnston; Elizabeth T Cox Lippard; Brian P Pittman; Cheryl Lacadie; Lawrence H Staib; Xenophon Papademetris; Hilary P Blumberg Journal: Biol Psychiatry Date: 2015-04-06 Impact factor: 13.382
Authors: Stephen M Strakowski; Caleb M Adler; Jorge Almeida; Lori L Altshuler; Hilary P Blumberg; Kiki D Chang; Melissa P DelBello; Sophia Frangou; Andrew McIntosh; Mary L Phillips; Jessika E Sussman; Jennifer D Townsend Journal: Bipolar Disord Date: 2012-06 Impact factor: 6.744
Authors: M A Brotman; W-L Tseng; A K Olsavsky; S J Fromm; E J Muhrer; J G Rutenberg; C M Deveney; N E Adleman; C A Zarate; D S Pine; E Leibenluft Journal: Psychol Med Date: 2013-08-12 Impact factor: 7.723
Authors: Joseph J Shaffer; Casey P Johnson; Jess G Fiedorowicz; Gary E Christensen; John A Wemmie; Vincent A Magnotta Journal: Brain Imaging Behav Date: 2018-06 Impact factor: 3.978