BACKGROUND: Patients with mania show a behavioral bias toward positive information in an emotional go/no go task. This is the converse of the bias toward negative information seen in unipolar depression that we have recently related to the abnormal function of ventral and medial prefrontal cortices (PFCs). The aim of this study was to investigate the neuronal basis of the bias toward positive information in manic patients. METHODS: During performance of an emotional go/no go task using functional magnetic resonance imaging, 8 manic patients and 11 healthy controls were scanned. The task allowed comparison between neural response to happy, sad, and neutral words in the context of these words being either targets or distracters. RESULTS: Manic patients showed attenuated orbitofrontal response when all the semantic conditions were compared with a control condition; however, they showed an enhanced response of the left ventrolateral PFC to emotional relative to neutral targets, as well as enhanced ventral and medial prefrontal response to emotional, particularly happy, distracters. CONCLUSIONS: These results suggest a critical role for ventral and medial dysfunction in the pathology of mania, which might underpin aspects of cognitive and clinical symptomatology. Copyright 2004 Society of Biological Psychiatry
BACKGROUND:Patients with mania show a behavioral bias toward positive information in an emotional go/no go task. This is the converse of the bias toward negative information seen in unipolar depression that we have recently related to the abnormal function of ventral and medial prefrontal cortices (PFCs). The aim of this study was to investigate the neuronal basis of the bias toward positive information in manicpatients. METHODS: During performance of an emotional go/no go task using functional magnetic resonance imaging, 8 manicpatients and 11 healthy controls were scanned. The task allowed comparison between neural response to happy, sad, and neutral words in the context of these words being either targets or distracters. RESULTS:Manicpatients showed attenuated orbitofrontal response when all the semantic conditions were compared with a control condition; however, they showed an enhanced response of the left ventrolateral PFC to emotional relative to neutral targets, as well as enhanced ventral and medial prefrontal response to emotional, particularly happy, distracters. CONCLUSIONS: These results suggest a critical role for ventral and medial dysfunction in the pathology of mania, which might underpin aspects of cognitive and clinical symptomatology. Copyright 2004 Society of Biological Psychiatry
Authors: Nathalie Vizueta; Jeffrey D Rudie; Jennifer D Townsend; Salvatore Torrisi; Teena D Moody; Susan Y Bookheimer; Lori L Altshuler Journal: Am J Psychiatry Date: 2012-08 Impact factor: 18.112
Authors: Kurt P Schulz; Jin Fan; Olga Magidina; David J Marks; Bella Hahn; Jeffrey M Halperin Journal: Arch Clin Neuropsychol Date: 2007-01-04 Impact factor: 2.813
Authors: A E Doyle; J Wozniak; T E Wilens; A Henin; L J Seidman; C Petty; R Fried; L M Gross; S V Faraone; J Biederman Journal: Psychol Med Date: 2008-12-11 Impact factor: 7.723
Authors: Daniel P Dickstein; Brendan A Rich; Roxann Roberson-Nay; Lisa Berghorst; Deborah Vinton; Daniel S Pine; Ellen Leibenluft Journal: Bipolar Disord Date: 2007-11 Impact factor: 6.744
Authors: Gonçalo Cotovio; Daniel Talmasov; J Bernardo Barahona-Corrêa; Joey Hsu; Suhan Senova; Ricardo Ribeiro; Louis Soussand; Ana Velosa; Vera Cruz E Silva; Natalia Rost; Ona Wu; Alexander L Cohen; Albino J Oliveira-Maia; Michael D Fox Journal: J Clin Invest Date: 2020-10-01 Impact factor: 14.808