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Literature DB >> 22520977

Topoisomerase 1 inhibitors and cancer therapy.

Julia Moukharskaya¹, Claire Verschraegen.

Abstract

Topoisomerase 1 inhibitors cure human cancer xenografts in animal models, more so than most other chemotherapy agents. However, their activity in patients with cancer is modest. Ongoing research is studying the optimal analogues that could reproduce animal data in the cancer population. This article analyzes the clinical research with topoisomerase 1 inhibitors in ovarian cancer.

Entities: Disease Species

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Year: 2012 PMID： 22520977 DOI： 10.1016/j.hoc.2012.03.002

Source DB: PubMed Journal: Hematol Oncol Clin North Am ISSN： 0889-8588 Impact factor: 3.722

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Cited

14 in total

1. Transgene-mediated co-suppression of DNA topoisomerase-1 gene in Caenorhabditis elegans.

Authors: Myon-Hee Lee; Dong Seok Cha; Srivalli Swathi Mamillapalli; Young Chul Kwon; Hyeon-Sook Koo
Journal: Int J Biochem Mol Biol Date: 2014-05-15

2. Gli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitors.

Authors: Kaushlendra Tripathi; Chinnadurai Mani; Reagan Barnett; Sriram Nalluri; Lavanya Bachaboina; Rodney P Rocconi; Mohammed Athar; Laurie B Owen; Komaraiah Palle
Journal: J Biol Chem Date: 2014-09-24 Impact factor: 5.157

3. Physicochemical characterization of 9-aminocamptothecin in aqueous solutions.

Authors: Shahidur Rahman; Deval Patel; Michalakis Savva
Journal: AAPS PharmSciTech Date: 2013-12-03 Impact factor: 3.246

Review 4. Recent advances in isolation, synthesis, and evaluation of bioactivities of bispyrroloquinone alkaloids of marine origin.

Authors: Bhavitavya Nijampatnam; Shilpa Dutta; Sadanandan E Velu
Journal: Chin J Nat Med Date: 2015-08

5. A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors.

Authors: Andrea E Wahner Hendrickson; Michael E Menefee; Lynn C Hartmann; Harry J Long; Donald W Northfelt; Joel M Reid; Felix Boakye-Agyeman; Olumide Kayode; Karen S Flatten; Maria I Harrell; Elizabeth M Swisher; Guy G Poirier; Daniel Satele; Jake Allred; Janet L Lensing; Alice Chen; Jiuping Ji; Yiping Zang; Charles Erlichman; Paul Haluska; Scott H Kaufmann
Journal: Clin Cancer Res Date: 2017-11-14 Impact factor: 12.531

10. A Biophysical Insight of Camptothecin Biodistribution: Towards a Molecular Understanding of Its Pharmacokinetic Issues.

Authors: Andreia Almeida; Eduarda Fernandes; Bruno Sarmento; Marlene Lúcio
Journal: Pharmaceutics Date: 2021-06-12 Impact factor: 6.321

Topoisomerase 1 inhibitors and cancer therapy.

1. Transgene-mediated co-suppression of DNA topoisomerase-1 gene in Caenorhabditis elegans.

2. Gli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitors.

3. Physicochemical characterization of 9-aminocamptothecin in aqueous solutions.

Review 4. Recent advances in isolation, synthesis, and evaluation of bioactivities of bispyrroloquinone alkaloids of marine origin.

5. A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors.

6. Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons.

Review 7. The Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human Cancer.

8. Immunodetection of human topoisomerase I-DNA covalent complexes.

9. Novel drugs in pediatric gliomas.

10. A Biophysical Insight of Camptothecin Biodistribution: Towards a Molecular Understanding of Its Pharmacokinetic Issues.