| Literature DB >> 2251683 |
Y A Barry1, R S Labow, W J Keon, M Tocchi.
Abstract
Di(2-ethylhexyl)phthalate (DEHP) is a commonly used plasticizer in polyvinylchloride (PVC)-derived plastic. Mono(2-ethylhexyl)phthalate (MEHP), the major metabolite of DEHP, had a reversible, concentration-dependent (15-200 micrograms/ml) negative inotropic effect on a human in vitro atrial trabecular isometric preparation with an IC50 of 85 micrograms/ml. When atropine (22-32 micrograms/ml) was included in the atrial preparation the IC50 was shifted to greater than 120 micrograms/ml, suggesting that MEHP acts in part through the cholinergic receptors.Entities:
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Year: 1990 PMID： 2251683 DOI： 10.1016/0041-008x(90)90104-3
Source DB: PubMed Journal: Toxicol Appl Pharmacol ISSN： 0041-008X Impact factor: 4.219