RATIONALE AND OBJECTIVES: The aim of this study was to identify clinically useful tumor/normal brain apparent diffusion coefficient (ADC) ratios for distinguishing common pediatric cerebellar tumors. MATERIALS AND METHODS: Review of medical records revealed 79 patients with cerebellar tumors who underwent preoperative magnetic resonance imaging, including diffusion-weighted imaging sequences, and surgery. There were 31 pilocytic astrocytomas, 27 medulloblastomas, 14 ependymomas, and seven atypical teratoid/rhabdoid tumors. ADC values were measured by placing regions of interest on the solid tumor and normal brain parenchyma by two reviewers. Tumor/normal brain ADC ratios were calculated. RESULTS: Mean ADC values of the pilocytic astrocytomas were greater than those of ependymomas, whose mean ADC values were greater than those of medulloblastomas and atypical teratoid/rhabdoid tumors. Using a tumor/normal brain ADC ratio threshold of 1.70 to distinguish pilocytic astrocytomas from ependymomas, sensitivity of 92% and specificity of 79% were achieved. A tumor/normal brain ADC ratio threshold of 1.20 enabled the sorting of ependymomas from medulloblastomas with sensitivity of 93% and specificity of 88%. CONCLUSIONS: Tumor/normal brain ADC ratios allow the distinguishing of common pediatric cerebellar tumors.
RATIONALE AND OBJECTIVES: The aim of this study was to identify clinically useful tumor/normal brain apparent diffusion coefficient (ADC) ratios for distinguishing common pediatric cerebellar tumors. MATERIALS AND METHODS: Review of medical records revealed 79 patients with cerebellar tumors who underwent preoperative magnetic resonance imaging, including diffusion-weighted imaging sequences, and surgery. There were 31 pilocytic astrocytomas, 27 medulloblastomas, 14 ependymomas, and seven atypical teratoid/rhabdoid tumors. ADC values were measured by placing regions of interest on the solid tumor and normal brain parenchyma by two reviewers. Tumor/normal brain ADC ratios were calculated. RESULTS: Mean ADC values of the pilocytic astrocytomas were greater than those of ependymomas, whose mean ADC values were greater than those of medulloblastomas and atypical teratoid/rhabdoid tumors. Using a tumor/normal brain ADC ratio threshold of 1.70 to distinguish pilocytic astrocytomas from ependymomas, sensitivity of 92% and specificity of 79% were achieved. A tumor/normal brain ADC ratio threshold of 1.20 enabled the sorting of ependymomas from medulloblastomas with sensitivity of 93% and specificity of 88%. CONCLUSIONS:Tumor/normal brain ADC ratios allow the distinguishing of common pediatric cerebellar tumors.
Authors: K Koral; S Zhang; L Gargan; W Moore; B Garvey; M Fiesta; M Seymour; L Yang; D Scott; N Choudhury Journal: AJNR Am J Neuroradiol Date: 2013-06-20 Impact factor: 3.825
Authors: Yi Sui; He Wang; Guanzhong Liu; Frederick W Damen; Christian Wanamaker; Yuhua Li; Xiaohong Joe Zhou Journal: Radiology Date: 2015-06-02 Impact factor: 11.105
Authors: H Zhou; R Hu; O Tang; C Hu; L Tang; K Chang; Q Shen; J Wu; B Zou; B Xiao; J Boxerman; W Chen; R Y Huang; L Yang; H X Bai; C Zhu Journal: AJNR Am J Neuroradiol Date: 2020-07 Impact factor: 3.825
Authors: Huagang Hou; Venkata Krishnamurthy Nemani; Gaixin Du; Ryan Montano; Rui Song; Barjor Gimi; Harold M Swartz; Alan Eastman; Nadeem Khan Journal: Int J Cancer Date: 2014-08-22 Impact factor: 7.396