OBJECTIVE: We investigated in a sham-controlled trial the analgesic effects of a 4-week treatment of transcranial direct current stimulation (tDCS) over the primary motor cortex in chronic migraine. In addition, using a high-resolution tDCS computational model, we analyzed the current flow (electric field) through brain regions associated with pain perception and modulation. METHODS:Thirteen patients with chronic migraine were randomized to receive 10 sessions of active or sham tDCS for 20 minutes with 2 mA over 4 weeks. Data were collected during baseline, treatment and follow-up. For the tDCS computational analysis, we adapted a high-resolution individualized model incorporating accurate segmentation of cortical and subcortical structures of interest. RESULTS: There was a significant interaction term (time vs group) for the main outcome (pain intensity) and for the length of migraine episodes (ANOVA, P < .05 for both analyses). Post-hoc analysis showed a significant improvement in the follow-up period for the active tDCS group only. Our computational modeling studies predicted electric current flow in multiple cortical and subcortical regions associated with migraine pathophysiology. Significant electric fields were generated, not only in targeted cortical regions but also in the insula, cingulate cortex, thalamus, and brainstem regions. CONCLUSIONS: Our findings give preliminary evidence that patients with chronic migraine have a positive, but delayed, response to anodal tDCS of the primary motor cortex. These effects may be related to electrical currents induced in pain-related cortical and subcortical regions.
RCT Entities:
OBJECTIVE: We investigated in a sham-controlled trial the analgesic effects of a 4-week treatment of transcranial direct current stimulation (tDCS) over the primary motor cortex in chronic migraine. In addition, using a high-resolution tDCS computational model, we analyzed the current flow (electric field) through brain regions associated with pain perception and modulation. METHODS: Thirteen patients with chronic migraine were randomized to receive 10 sessions of active or sham tDCS for 20 minutes with 2 mA over 4 weeks. Data were collected during baseline, treatment and follow-up. For the tDCS computational analysis, we adapted a high-resolution individualized model incorporating accurate segmentation of cortical and subcortical structures of interest. RESULTS: There was a significant interaction term (time vs group) for the main outcome (pain intensity) and for the length of migraine episodes (ANOVA, P < .05 for both analyses). Post-hoc analysis showed a significant improvement in the follow-up period for the active tDCS group only. Our computational modeling studies predicted electric current flow in multiple cortical and subcortical regions associated with migraine pathophysiology. Significant electric fields were generated, not only in targeted cortical regions but also in the insula, cingulate cortex, thalamus, and brainstem regions. CONCLUSIONS: Our findings give preliminary evidence that patients with chronic migraine have a positive, but delayed, response to anodal tDCS of the primary motor cortex. These effects may be related to electrical currents induced in pain-related cortical and subcortical regions.
Authors: Felipe Fregni; Paulo S Boggio; Michael A Nitsche; Sergio P Rigonatti; Alvaro Pascual-Leone Journal: Depress Anxiety Date: 2006 Impact factor: 6.505
Authors: J Olesen; M-G Bousser; H-C Diener; D Dodick; M First; P J Goadsby; H Göbel; M J A Lainez; J W Lance; R B Lipton; G Nappi; F Sakai; J Schoenen; S D Silberstein; T J Steiner Journal: Cephalalgia Date: 2006-06 Impact factor: 6.292
Authors: Felipe Fregni; Paulo S Boggio; Moises C Lima; Merari J L Ferreira; Tim Wagner; Sergio P Rigonatti; Anita W Castro; Daniel R Souza; Marcelo Riberto; Steven D Freedman; Michael A Nitsche; Alvaro Pascual-Leone Journal: Pain Date: 2006-03-27 Impact factor: 6.961
Authors: Felipe Fregni; Rafaela Gimenes; Angela C Valle; Merari J L Ferreira; Renata R Rocha; Luane Natalle; Riviane Bravo; Sergio P Rigonatti; Steven D Freedman; Michael A Nitsche; Alvaro Pascual-Leone; Paulo S Boggio Journal: Arthritis Rheum Date: 2006-12
Authors: Petra Schweinhardt; Chris Glynn; Jonathan Brooks; Henry McQuay; Tim Jack; Iain Chessell; Chas Bountra; Irene Tracey Journal: Neuroimage Date: 2006-05-05 Impact factor: 6.556
Authors: Tim Wagner; Felipe Fregni; Shirley Fecteau; Alan Grodzinsky; Markus Zahn; Alvaro Pascual-Leone Journal: Neuroimage Date: 2007-02-04 Impact factor: 6.556
Authors: J P Lefaucheur; S Hatem; A Nineb; I Ménard-Lefaucheur; S Wendling; Y Keravel; J P Nguyen Journal: Neurology Date: 2006-12-12 Impact factor: 9.910
Authors: A Antal; I Alekseichuk; M Bikson; J Brockmöller; A R Brunoni; R Chen; L G Cohen; G Dowthwaite; J Ellrich; A Flöel; F Fregni; M S George; R Hamilton; J Haueisen; C S Herrmann; F C Hummel; J P Lefaucheur; D Liebetanz; C K Loo; C D McCaig; C Miniussi; P C Miranda; V Moliadze; M A Nitsche; R Nowak; F Padberg; A Pascual-Leone; W Poppendieck; A Priori; S Rossi; P M Rossini; J Rothwell; M A Rueger; G Ruffini; K Schellhorn; H R Siebner; Y Ugawa; A Wexler; U Ziemann; M Hallett; W Paulus Journal: Clin Neurophysiol Date: 2017-06-19 Impact factor: 3.708
Authors: Jin Cao; Yiheng Tu; Scott P Orr; Courtney Lang; Joel Park; Mark Vangel; Lucy Chen; Randy Gollub; Jian Kong Journal: Cereb Cortex Date: 2019-07-22 Impact factor: 5.357
Authors: Mark P Jackson; Dennis Truong; Milene L Brownlow; Jessica A Wagner; R Andy McKinley; Marom Bikson; Ryan Jankord Journal: Brain Behav Immun Date: 2017-04-17 Impact factor: 7.217
Authors: Markus A Dahlem; Sebastian Rode; Arne May; Naoya Fujiwara; Yoshito Hirata; Kazuyuki Aihara; Jürgen Kurths Journal: Transl Neurosci Date: 2013-09 Impact factor: 1.757