Literature DB >> 22508723

A complex Polycomb issue: the two faces of EZH2 in cancer.

Hanno Hock1.   

Abstract

In the April 1, 2012, issue of Genes & Development, Simon and colleagues (pp. 651-656) demonstrated that the disruption of Ezh2 in mice is sufficient to cause T-acute lymphoblastic leukemia (T-ALL). Moreover, in concert with concurrent studies, the authors revealed that similar mechanisms are involved in human T-ALL. These data contrast with previous findings showing that increased EZH2 activity promotes cancer.

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Year:  2012        PMID： 22508723      PMCID： PMC3337450          DOI： 10.1101/gad.191163.112

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  46 in total

1.  Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.

Authors:  Ian J Majewski; Matthew E Ritchie; Belinda Phipson; Jason Corbin; Miha Pakusch; Anja Ebert; Meinrad Busslinger; Haruhiko Koseki; Yifang Hu; Gordon K Smyth; Warren S Alexander; Douglas J Hilton; Marnie E Blewitt
Journal:  Blood       Date:  2010-05-05       Impact factor: 22.113

2.  Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.

Authors:  Christopher J Sneeringer; Margaret Porter Scott; Kevin W Kuntz; Sarah K Knutson; Roy M Pollock; Victoria M Richon; Robert A Copeland
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-15       Impact factor: 11.205

3.  Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.

Authors:  Sara A Miller; Sarah E Mohn; Amy S Weinmann
Journal:  Mol Cell       Date:  2010-11-24       Impact factor: 17.970

4.  Clinical effect of point mutations in myelodysplastic syndromes.

Authors:  Rafael Bejar; Kristen Stevenson; Omar Abdel-Wahab; Naomi Galili; Björn Nilsson; Guillermo Garcia-Manero; Hagop Kantarjian; Azra Raza; Ross L Levine; Donna Neuberg; Benjamin L Ebert
Journal:  N Engl J Med       Date:  2011-06-30       Impact factor: 91.245

5.  EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.

Authors:  Elena Ezhkova; Wen-Hui Lien; Nicole Stokes; H Amalia Pasolli; Jose M Silva; Elaine Fuchs
Journal:  Genes Dev       Date:  2011-02-11       Impact factor: 11.361

Review 6.  Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.

Authors:  Jon C Aster; Stephen C Blacklow; Warren S Pear
Journal:  J Pathol       Date:  2010-10-21       Impact factor: 7.996

7.  Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes.

Authors:  Gorica Nikoloski; Saskia M C Langemeijer; Roland P Kuiper; Ruth Knops; Marion Massop; Evelyn R L T M Tönnissen; Adrian van der Heijden; Theresia N Scheele; Peter Vandenberghe; Theo de Witte; Bert A van der Reijden; Joop H Jansen
Journal:  Nat Genet       Date:  2010-07-04       Impact factor: 38.330

8.  The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's Lymphoma.

Authors:  J A Anderton; S Bose; M Vockerodt; K Vrzalikova; W Wei; M Kuo; K Helin; J Christensen; M Rowe; P G Murray; C B Woodman
Journal:  Oncogene       Date:  2011-01-17       Impact factor: 9.867

9.  Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation.

Authors:  Boris G Wilson; Xi Wang; Xiaohua Shen; Elizabeth S McKenna; Madeleine E Lemieux; Yoon-Jae Cho; Edward C Koellhoffer; Scott L Pomeroy; Stuart H Orkin; Charles W M Roberts
Journal:  Cancer Cell       Date:  2010-10-19       Impact factor: 31.743

Review 10.  The Polycomb complex PRC2 and its mark in life.

Authors:  Raphaël Margueron; Danny Reinberg
Journal:  Nature       Date:  2011-01-20       Impact factor: 49.962
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  64 in total

1.  The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.

Authors:  Jinzhong Qin; Warren A Whyte; Endre Anderssen; Effie Apostolou; Hsu-Hsin Chen; Schahram Akbarian; Roderick T Bronson; Konrad Hochedlinger; Sridhar Ramaswamy; Richard A Young; Hanno Hock
Journal:  Cell Stem Cell       Date:  2012-07-05       Impact factor: 24.633

Review 2.  The Necessity of Chromatin: A View in Perspective.

Authors:  Vincenzo Pirrotta
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-01-04       Impact factor: 10.005

3.  Inhibition of EZH2 expression is associated with the proliferation, apoptosis and migration of SW620 colorectal cancer cells in vitro.

Authors:  He Song-Bing; Zhou Hao; Zhou Jian; Zhou Guo-Qiang; Han Tuo; Wan Dai-Wei; Gu Wen; Gao Lin; Zhang Yi; Xue Xiao-Feng; Zhang Li-Feng; Fei Min; Hi Shui-Qing; Yang Xiao-Dong; Zhu Xin-Guo; Wang Liang; Li De-Chun
Journal:  Exp Biol Med (Maywood)       Date:  2015-02-27

4.  An aromatic cage is required but not sufficient for binding of Tudor domains of the Polycomblike protein family to H3K36me3.

Authors:  Jovylyn Gatchalian; Molly C Kingsley; Stacey D Moslet; Ruben D Rosas Ospina; Tatiana G Kutateladze
Journal:  Epigenetics       Date:  2015-04-29       Impact factor: 4.528

Review 5.  Point mutations in an epigenetic factor lead to multiple types of bone tumors: role of H3.3 histone variant in bone development and disease.

Authors:  Shigeaki Kato; Takeaki Ishii; Alexander Kouzmenko
Journal:  Bonekey Rep       Date:  2015-07-01

Review 6.  The regulation of cell-cell adhesion during epithelial-mesenchymal transition, motility and tumor progression.

Authors:  Grégoire F Le Bras; Kenneth J Taubenslag; Claudia D Andl
Journal:  Cell Adh Migr       Date:  2012-07-01       Impact factor: 3.405

7.  Reactive oxygen species contribute to arsenic-induced EZH2 phosphorylation in human bronchial epithelial cells and lung cancer cells.

Authors:  Lingzhi Li; Ping Qiu; Bailing Chen; Yongju Lu; Kai Wu; Chitra Thakur; Qingshan Chang; Jiaying Sun; Fei Chen
Journal:  Toxicol Appl Pharmacol       Date:  2014-02-25       Impact factor: 4.219

8.  Histone H3K27 Trimethylation Modulates 5-Fluorouracil Resistance by Inhibiting PU.1 Binding to the DPYD Promoter.

Authors:  Rentian Wu; Qian Nie; Erin E Tapper; Calvin R Jerde; Garrett S Dunlap; Shikshya Shrestha; Tarig A Elraiyah; Steven M Offer; Robert B Diasio
Journal:  Cancer Res       Date:  2016-08-30       Impact factor: 12.701

9.  STAT3-driven transcription depends upon the dimethylation of K49 by EZH2.

Authors:  Maupali Dasgupta; Josephine Kam Tai Dermawan; Belinda Willard; George R Stark
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-12       Impact factor: 11.205

10.  Integrative Analysis Reveals the Transcriptional Collaboration between EZH2 and E2F1 in the Regulation of Cancer-Related Gene Expression.

Authors:  Han Xu; Kexin Xu; Housheng H He; Chongzhi Zang; Chen-Hao Chen; Yiwen Chen; Qian Qin; Su Wang; Chenfei Wang; Shengen Hu; Fugen Li; Henry Long; Myles Brown; X Shirley Liu
Journal:  Mol Cancer Res       Date:  2015-12-09       Impact factor: 5.852
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