Literature DB >> 22508696

Nodal expression and detection in cancer: experience and challenges.

Luigi Strizzi1, Katharine M Hardy, Dawn A Kirschmann, Lars Ahrlund-Richter, Mary J C Hendrix.   

Abstract

Nodal is a TGF-β-related embryonic morphogen that is expressed in multiple human cancers. Detection of Nodal expression in these tissues can be challenging if issues related to Nodal transcription and protein processing are not considered. Here, we discuss certain characteristics related to Nodal expression and function and how these can facilitate acquisition and interpretation of expression data, contributing to our understanding of the potential role of Nodal in human cancer. We also discuss how Nodal could be exploited clinically as a novel biomarker for cancer progression and therapeutic target.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22508696      PMCID： PMC3334352          DOI： 10.1158/0008-5472.CAN-11-3419

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  26 in total

Review 1.  Running the gauntlet: an overview of the modalities of travel employed by the putative morphogen Nodal.

Authors:  Daniel B Constam
Journal:  Curr Opin Genet Dev       Date:  2009-07-22       Impact factor: 5.578

2.  Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells.

Authors:  Mitchell G Lawrence; Naira V Margaryan; Daniela Loessner; Angus Collins; Kris M Kerr; Megan Turner; Elisabeth A Seftor; Carson R Stephens; John Lai; Lynne-Marie Postovit; Judith A Clements; Mary J C Hendrix
Journal:  Prostate       Date:  2011-01-12       Impact factor: 4.104

3.  Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases.

Authors:  Keiran S M Smalley; Nikolas K Haass; Patricia A Brafford; Mercedes Lioni; Keith T Flaherty; Meenhard Herlyn
Journal:  Mol Cancer Ther       Date:  2006-05       Impact factor: 6.261

4.  Expression of nodal signalling components in cycling human endometrium and in endometrial cancer.

Authors:  Irene Papageorgiou; Peter K Nicholls; Fang Wang; Martin Lackmann; Yogeshwar Makanji; Lois A Salamonsen; David M Robertson; Craig A Harrison
Journal:  Reprod Biol Endocrinol       Date:  2009-10-29       Impact factor: 5.211

5.  Nodal as a biomarker for melanoma progression and a new therapeutic target for clinical intervention.

Authors:  Luigi Strizzi; Lynne-Marie Postovit; Naira V Margaryan; Alina Lipavsky; Jules Gadiot; Christian Blank; Richard Eb Seftor; Elisabeth A Seftor; Mary Jc Hendrix
Journal:  Expert Rev Dermatol       Date:  2009

6.  Extraembryonic proteases regulate Nodal signalling during gastrulation.

Authors:  Séverine Beck; J Ann Le Good; Marcela Guzman; Nadav Ben Haim; Karine Roy; Friedrich Beermann; Daniel B Constam
Journal:  Nat Cell Biol       Date:  2002-12       Impact factor: 28.824

Review 7.  Development and cancer: at the crossroads of Nodal and Notch signaling.

Authors:  Luigi Strizzi; Katharine M Hardy; Elisabeth A Seftor; Fabricio F Costa; Dawn A Kirschmann; Richard E B Seftor; Lynne-Marie Postovit; Mary J C Hendrix
Journal:  Cancer Res       Date:  2009-09-08       Impact factor: 12.701

8.  Cripto-1 overexpression leads to enhanced invasiveness and resistance to anoikis in human MCF-7 breast cancer cells.

Authors:  Nicola Normanno; Antonella De Luca; Caterina Bianco; Monica R Maiello; Maria V Carriero; Aasia Rehman; Christian Wechselberger; Claudio Arra; Luigi Strizzi; Michele Sanicola; David S Salomon
Journal:  J Cell Physiol       Date:  2004-01       Impact factor: 6.384

Review 9.  Targeting BRAF for patients with melanoma.

Authors:  H-T Arkenau; R Kefford; G V Long
Journal:  Br J Cancer       Date:  2010-12-07       Impact factor: 7.640

Review 10.  Main roads to melanoma.

Authors:  Giuseppe Palmieri; Mariaelena Capone; Maria Libera Ascierto; Giusy Gentilcore; David F Stroncek; Milena Casula; Maria Cristina Sini; Marco Palla; Nicola Mozzillo; Paolo A Ascierto
Journal:  J Transl Med       Date:  2009-10-14       Impact factor: 5.531
View more
  21 in total

1.  Aldehyde Dehydragenase 1 and Nodal as Significant Prognostic Markers in Colorectal Cancer.

Authors:  Hui Li; Yang Jiang; Fenghua Pei; Lu Li; Bingzhu Yan; Xinyu Geng; Bingrong Liu
Journal:  Pathol Oncol Res       Date:  2015-09-10       Impact factor: 3.201

Review 2.  Melanoma tumor cell heterogeneity: a molecular approach to study subpopulations expressing the embryonic morphogen nodal.

Authors:  Elisabeth A Seftor; Richard E B Seftor; Don Weldon; Gina T Kirsammer; Naira V Margaryan; Alina Gilgur; Mary J C Hendrix
Journal:  Semin Oncol       Date:  2014-02-07       Impact factor: 4.929

3.  Hypoxia induced-disruption of lncRNA TUG1/PRC2 interaction impairs human trophoblast invasion through epigenetically activating Nodal/ALK7 signalling.

Authors:  Mengsi Hu; Yao Wang; Yanping Meng; Jinxiu Hu; Jiao Qiao; Junhui Zhen; Decai Liang; Minghua Fan
Journal:  J Cell Mol Med       Date:  2022-06-21       Impact factor: 5.295

4.  Plasticity underlies tumor progression: role of Nodal signaling.

Authors:  Thomas M Bodenstine; Grace S Chandler; Richard E B Seftor; Elisabeth A Seftor; Mary J C Hendrix
Journal:  Cancer Metastasis Rev       Date:  2016-03       Impact factor: 9.264

Review 5.  Beyond TGFβ: roles of other TGFβ superfamily members in cancer.

Authors:  Lalage M Wakefield; Caroline S Hill
Journal:  Nat Rev Cancer       Date:  2013-05       Impact factor: 60.716

6.  Expression and significance of Nodal in human cancers: a meta-analysis.

Authors:  Fen Ning; Hai-Fang Wang; Qiang Guo; Zong-Cai Liu; Zi-Qian Li; Jun Du
Journal:  Int J Clin Exp Med       Date:  2015-11-15

Review 7.  Tumor cell vasculogenic mimicry: from controversy to therapeutic promise.

Authors:  Richard E B Seftor; Angela R Hess; Elisabeth A Seftor; Dawn A Kirschmann; Katharine M Hardy; Naira V Margaryan; Mary J C Hendrix
Journal:  Am J Pathol       Date:  2012-08-31       Impact factor: 4.307

8.  Expression of Nodal, Cripto, SMAD3, phosphorylated SMAD3, and SMAD4 in the proliferative endometrium of women with endometriosis.

Authors:  Cynthia Dela Cruz; Helen L Del Puerto; Ana Luiza L Rocha; Inês K Cavallo; Alessandra D Clarizia; Felice Petraglia; Fernando M Reis
Journal:  Reprod Sci       Date:  2014-09-16       Impact factor: 3.060

Review 9.  TGFB1/INHBA Homodimer/Nodal-SMAD2/3 Signaling Network: A Pivotal Molecular Target in PDAC Treatment.

Authors:  Mai Abdel Mouti; Siim Pauklin
Journal:  Mol Ther       Date:  2021-01-09       Impact factor: 11.454

Review 10.  Dynamics of Transforming Growth Factor Beta Signaling in Wound Healing and Scarring.

Authors:  Kenneth W Finnson; Sarah McLean; Gianni M Di Guglielmo; Anie Philip
Journal:  Adv Wound Care (New Rochelle)       Date:  2013-06       Impact factor: 4.730
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.