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Literature DB >> 24787297

Melanoma tumor cell heterogeneity: a molecular approach to study subpopulations expressing the embryonic morphogen nodal.

Elisabeth A Seftor¹, Richard E B Seftor¹, Don Weldon², Gina T Kirsammer¹, Naira V Margaryan¹, Alina Gilgur¹, Mary J C Hendrix¹.

Abstract

As the frequency of melanoma increases, current treatment strategies are struggling to significantly impact patient survival. One of the critical issues in designing efficient therapies is understanding the composition of heterogeneous melanoma tumors in order to target cancer stem cells (CSCs) and drug-resistant subpopulations. In this review, we summarize recent findings pertinent to the reemergence of the embryonic Nodal signaling pathway in melanoma and its significance as a prognostic biomarker and therapeutic target. In addition, we offer a novel molecular approach to studying the functional relevance of Nodal-expressing subpopulations and their CSC phenotype.

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Year: 2014 PMID： 24787297 PMCID： PMC4026856 DOI： 10.1053/j.seminoncol.2014.02.001

Source DB: PubMed Journal: Semin Oncol ISSN： 0093-7754 Impact factor: 4.929

34 in total

1. Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells.

Authors: Mitchell G Lawrence; Naira V Margaryan; Daniela Loessner; Angus Collins; Kris M Kerr; Megan Turner; Elisabeth A Seftor; Carson R Stephens; John Lai; Lynne-Marie Postovit; Judith A Clements; Mary J C Hendrix
Journal: Prostate Date: 2011-01-12 Impact factor: 4.104

2. Interactions between cancer stem cells and their niche govern metastatic colonization.

Authors: Ilaria Malanchi; Albert Santamaria-Martínez; Evelyn Susanto; Hong Peng; Hans-Anton Lehr; Jean-Francois Delaloye; Joerg Huelsken
Journal: Nature Date: 2011-12-07 Impact factor: 49.962

3. Expression of nodal signalling components in cycling human endometrium and in endometrial cancer.

Authors: Irene Papageorgiou; Peter K Nicholls; Fang Wang; Martin Lackmann; Yogeshwar Makanji; Lois A Salamonsen; David M Robertson; Craig A Harrison
Journal: Reprod Biol Endocrinol Date: 2009-10-29 Impact factor: 5.211

4. Nodal as a biomarker for melanoma progression and a new therapeutic target for clinical intervention.

Authors: Luigi Strizzi; Lynne-Marie Postovit; Naira V Margaryan; Alina Lipavsky; Jules Gadiot; Christian Blank; Richard Eb Seftor; Elisabeth A Seftor; Mary Jc Hendrix
Journal: Expert Rev Dermatol Date: 2009

Review 5. Cancer stem cells and human malignant melanoma.

Authors: Tobias Schatton; Markus H Frank
Journal: Pigment Cell Melanoma Res Date: 2008-02 Impact factor: 4.693

6. NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL/SMAD3 signaling pathway.

Authors: Chun Sun; Lu Sun; Kai Jiang; Dong-Mei Gao; Xiao-Nan Kang; Cun Wang; Shu Zhang; Shan Huang; Xue Qin; Yan Li; Yin-Kun Liu
Journal: Int J Biochem Cell Biol Date: 2013-03-07 Impact factor: 5.085

Review 7. Patient-derived xenografts, the cancer stem cell paradigm, and cancer pathobiology in the 21st century.

Authors: Samuel A Williams; Wade C Anderson; Marianne T Santaguida; Scott J Dylla
Journal: Lab Invest Date: 2013-08-05 Impact factor: 5.662

8. CD133+ melanoma subpopulations contribute to perivascular niche morphogenesis and tumorigenicity through vasculogenic mimicry.

Authors: Chiou-Yan Lai; Brian E Schwartz; Mei-Yu Hsu
Journal: Cancer Res Date: 2012-08-03 Impact factor: 12.701

9. Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.

Authors: Enza Lonardo; Patrick C Hermann; Maria-Theresa Mueller; Stephan Huber; Anamaria Balic; Irene Miranda-Lorenzo; Sladjana Zagorac; Sonia Alcala; Iker Rodriguez-Arabaolaza; Juan Carlos Ramirez; Raul Torres-Ruíz; Elena Garcia; Manuel Hidalgo; David Álvaro Cebrián; Rainer Heuchel; Matthias Löhr; Frank Berger; Peter Bartenstein; Alexandra Aicher; Christopher Heeschen
Journal: Cell Stem Cell Date: 2011-11-04 Impact factor: 24.633

10. Low oxygen levels induce the expression of the embryonic morphogen Nodal.

Authors: Daniela F Quail; Meghan J Taylor; Logan A Walsh; Dylan Dieters-Castator; Padmalaya Das; Michael Jewer; Guihua Zhang; Lynne-Marie Postovit
Journal: Mol Biol Cell Date: 2011-10-26 Impact factor: 4.138

17 in total

Review 1. Nanoparticle Probes for the Detection of Cancer Biomarkers, Cells, and Tissues by Fluorescence.

Authors: Alyssa B Chinen; Chenxia M Guan; Jennifer R Ferrer; Stacey N Barnaby; Timothy J Merkel; Chad A Mirkin
Journal: Chem Rev Date: 2015-08-27 Impact factor: 60.622

2. Murine melanoma cells incomplete reprogramming using non-viral vector.

Authors: D A D Câmara; A S Porcacchia; A S Costa; R A Azevedo; I Kerkis
Journal: Cell Prolif Date: 2017-06-15 Impact factor: 6.831

Review 3. Cancer Stem Cells (CSCs) in melanoma: There's smoke, but is there fire?

Authors: Constance E Brinckerhoff
Journal: J Cell Physiol Date: 2017-03-06 Impact factor: 6.384

4. Plasticity underlies tumor progression: role of Nodal signaling.

Authors: Thomas M Bodenstine; Grace S Chandler; Richard E B Seftor; Elisabeth A Seftor; Mary J C Hendrix
Journal: Cancer Metastasis Rev Date: 2016-03 Impact factor: 9.264

5. Cancer stem-like cells directly participate in vasculogenic mimicry channels in triple-negative breast cancer.

Authors: Huizhi Sun; Nan Yao; Siqi Cheng; Linqi Li; Shiqi Liu; Zhao Yang; Guanjie Shang; Danfang Zhang; Zhi Yao
Journal: Cancer Biol Med Date: 2019-05 Impact factor: 4.248

6. Inhibitor of DNA Binding 4 (ID4) is highly expressed in human melanoma tissues and may function to restrict normal differentiation of melanoma cells.

Authors: Yuval Peretz; Hong Wu; Shayan Patel; Alfonso Bellacosa; Richard A Katz
Journal: PLoS One Date: 2015-02-02 Impact factor: 3.240

7. Detection of Intracellular Gene Expression in Live Cells of Murine, Human and Porcine Origin Using Fluorescence-labeled Nanoparticles.

Authors: Harald Lahm; Stefanie A Doppler; Martina Dreßen; Klaudia Adamczyk; Marcus-André Deutsch; Hanna Ulrich; Matthias Schiemann; Rüdiger Lange; Markus Krane
Journal: J Vis Exp Date: 2015-11-13 Impact factor: 1.355