Literature DB >> 22505028

Shifting a complex debate on γ-secretase cleavage and Alzheimer's disease.

Todd E Golde1, Yong Ran, Kevin M Felsenstein.   

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Year:  2012        PMID： 22505028      PMCID： PMC3364746          DOI： 10.1038/emboj.2012.111

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


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  11 in total

1.  Gamma-secretase gene mutations in familial acne inversa.

Authors:  Baoxi Wang; Wei Yang; Wen Wen; Jing Sun; Bin Su; Bo Liu; Donglai Ma; Dan Lv; Yaran Wen; Tao Qu; Min Chen; Miao Sun; Yan Shen; Xue Zhang
Journal:  Science       Date:  2010-10-07       Impact factor: 47.728

Review 2.  The role of A beta 42 in Alzheimer's disease.

Authors:  S G Younkin
Journal:  J Physiol Paris       Date:  1998 Jun-Aug

3.  Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.

Authors:  Omar Quintero-Monzon; Morgan M Martin; Marty A Fernandez; Christina A Cappello; Amanda J Krzysiak; Pamela Osenkowski; Michael S Wolfe
Journal:  Biochemistry       Date:  2011-09-30       Impact factor: 3.162

Review 4.  The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism.

Authors:  Jie Shen; Raymond J Kelleher
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-29       Impact factor: 11.205

5.  The role of presenilin cofactors in the gamma-secretase complex.

Authors:  Nobumasa Takasugi; Taisuke Tomita; Ikuo Hayashi; Makiko Tsuruoka; Manabu Niimura; Yasuko Takahashi; Gopal Thinakaran; Takeshi Iwatsubo
Journal:  Nature       Date:  2003-03-16       Impact factor: 49.962

Review 6.  Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

Authors:  Edward H Koo; Raphael Kopan
Journal:  Nat Med       Date:  2004-07       Impact factor: 53.440

Review 7.  The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.

Authors:  John Hardy; Dennis J Selkoe
Journal:  Science       Date:  2002-07-19       Impact factor: 47.728

8.  gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

Authors:  Mako Takami; Yu Nagashima; Yoshihisa Sano; Seiko Ishihara; Maho Morishima-Kawashima; Satoru Funamoto; Yasuo Ihara
Journal:  J Neurosci       Date:  2009-10-14       Impact factor: 6.167

Review 9.  Rational targeting of Notch signaling in cancer.

Authors:  P Rizzo; C Osipo; K Foreman; T Golde; B Osborne; L Miele
Journal:  Oncogene       Date:  2008-09-01       Impact factor: 9.867

10.  The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.

Authors:  Lucía Chávez-Gutiérrez; Leen Bammens; Iryna Benilova; Annelies Vandersteen; Manasi Benurwar; Marianne Borgers; Sam Lismont; Lujia Zhou; Simon Van Cleynenbreugel; Hermann Esselmann; Jens Wiltfang; Lutgarde Serneels; Eric Karran; Harrie Gijsen; Joost Schymkowitz; Frederic Rousseau; Kerensa Broersen; Bart De Strooper
Journal:  EMBO J       Date:  2012-04-13       Impact factor: 11.598
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  5 in total

1.  Familial Alzheimer's mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site.

Authors:  Wen Chen; Eric Gamache; David J Rosenman; Jian Xie; Maria M Lopez; Yue-Ming Li; Chunyu Wang
Journal:  Nat Commun       Date:  2014       Impact factor: 14.919

2.  Molecular plasticity regulates oligomerization and cytotoxicity of the multipeptide-length amyloid-β peptide pool.

Authors:  Annelies Vandersteen; Marcelo F Masman; Greet De Baets; Wim Jonckheere; Kees van der Werf; Siewert J Marrink; Jef Rozenski; Iryna Benilova; Bart De Strooper; Vinod Subramaniam; Joost Schymkowitz; Frederic Rousseau; Kerensa Broersen
Journal:  J Biol Chem       Date:  2012-09-19       Impact factor: 5.157

3.  Modulation of gamma-secretase for the treatment of Alzheimer's disease.

Authors:  Barbara Tate; Timothy D McKee; Robyn M B Loureiro; Jo Ann Dumin; Weiming Xia; Kevin Pojasek; Wesley F Austin; Nathan O Fuller; Jed L Hubbs; Ruichao Shen; Jeff Jonker; Jeff Ives; Brian S Bronk
Journal:  Int J Alzheimers Dis       Date:  2012-12-19

4.  Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models.

Authors:  Robyn M Loureiro; Jo Ann Dumin; Timothy D McKee; Wesley F Austin; Nathan O Fuller; Jed L Hubbs; Ruichao Shen; Jeff Jonker; Jeff Ives; Brian S Bronk; Barbara Tate
Journal:  Alzheimers Res Ther       Date:  2013-04-18       Impact factor: 6.982

5.  Short Aβ peptides attenuate Aβ42 toxicity in vivo.

Authors:  Brenda D Moore; Jason Martin; Lorena de Mena; Jonatan Sanchez; Pedro E Cruz; Carolina Ceballos-Diaz; Thomas B Ladd; Yong Ran; Yona Levites; Thomas L Kukar; Justin J Kurian; Robert McKenna; Edward H Koo; David R Borchelt; Christopher Janus; Diego Rincon-Limas; Pedro Fernandez-Funez; Todd E Golde
Journal:  J Exp Med       Date:  2017-12-05       Impact factor: 14.307
  5 in total

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