Literature DB >> 22504805

High-throughput screening for Streptomyces antibiotic biosynthesis activators.

Li Chen1, Yemin Wang, Hang Guo, Min Xu, Zixin Deng, Meifeng Tao.   

Abstract

A genomic cosmid library of Streptomyces clavuligerus was constructed and transferred efficiently by conjugation to Streptomyces lividans, and 12 distinct groups of overlapping cosmid clones that activated the silent actinorhodin biosynthesis gene cluster were identified. This generally applicable high-throughput screening procedure greatly facilitates the identification of antibiotic biosynthesis activators.

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Year:  2012        PMID： 22504805      PMCID： PMC3370547          DOI： 10.1128/AEM.00348-12

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  22 in total

1.  X-14547A, a new ionophorous antibiotic produced by Streptomyces antibioticus NRRL 8167. Discovery, fermentation, biological properties and taxonomy of the producing culture.

Authors:  C M Liu; T E Hermann; M Liu; D N Bull; N J Palleroni; B L Prosser; J W Westley; P A Miller
Journal:  J Antibiot (Tokyo)       Date:  1979-02       Impact factor: 2.649

2.  afsR2: a previously undetected gene encoding a 63-amino-acid protein that stimulates antibiotic production in Streptomyces lividans.

Authors:  M Vögtli; P C Chang; S N Cohen
Journal:  Mol Microbiol       Date:  1994-11       Impact factor: 3.501

3.  Mutants of Streptomyces clavuligerus with disruptions in different genes for clavulanic acid biosynthesis produce large amounts of holomycin: possible cross-regulation of two unrelated secondary metabolic pathways.

Authors:  Alvaro de la Fuente; Luis M Lorenzana; Juan F Martín; Paloma Liras
Journal:  J Bacteriol       Date:  2002-12       Impact factor: 3.490

4.  abaA, a new pleiotropic regulatory locus for antibiotic production in Streptomyces coelicolor.

Authors:  M A Fernández-Moreno; A J Martín-Triana; E Martínez; J Niemi; H M Kieser; D A Hopwood; F Malpartida
Journal:  J Bacteriol       Date:  1992-05       Impact factor: 3.490

5.  Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

Authors:  M Bierman; R Logan; K O'Brien; E T Seno; R N Rao; B E Schoner
Journal:  Gene       Date:  1992-07-01       Impact factor: 3.688

6.  The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans.

Authors:  A Sola-Landa; R S Moura; J F Martín
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-02       Impact factor: 11.205

7.  A putative two-component regulatory system involved in secondary metabolism in Streptomyces spp.

Authors:  H Ishizuka; S Horinouchi; H M Kieser; D A Hopwood; T Beppu
Journal:  J Bacteriol       Date:  1992-12       Impact factor: 3.490

8.  ClgR, a novel regulator of clp and lon expression in Streptomyces.

Authors:  Audrey Bellier; Philippe Mazodier
Journal:  J Bacteriol       Date:  2004-05       Impact factor: 3.490

9.  Cloning of a pleiotropic gene that positively controls biosynthesis of A-factor, actinorhodin, and prodigiosin in Streptomyces coelicolor A3(2) and Streptomyces lividans.

Authors:  S Horinouchi; O Hara; T Beppu
Journal:  J Bacteriol       Date:  1983-09       Impact factor: 3.490

10.  Systematic insertional mutagenesis of a streptomycete genome: a link between osmoadaptation and antibiotic production.

Authors:  Amy Bishop; Sue Fielding; Paul Dyson; Paul Herron
Journal:  Genome Res       Date:  2004-04-12       Impact factor: 9.043
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  5 in total

1.  Biosynthesis of Tropolones in Streptomyces spp.: Interweaving Biosynthesis and Degradation of Phenylacetic Acid and Hydroxylations on the Tropone Ring.

Authors:  Xuefei Chen; Min Xu; Jin Lü; Jianguo Xu; Yemin Wang; Shuangjun Lin; Zixin Deng; Meifeng Tao
Journal:  Appl Environ Microbiol       Date:  2018-05-31       Impact factor: 4.792

Review 2.  Heterologous expression-facilitated natural products' discovery in actinomycetes.

Authors:  Min Xu; Gerard D Wright
Journal:  J Ind Microbiol Biotechnol       Date:  2018-11-16       Impact factor: 3.346

3.  Combining transposon mutagenesis and reporter genes to identify novel regulators of the topA promoter in Streptomyces.

Authors:  Martyna Gongerowska-Jac; Marcin Jan Szafran; Dagmara Jakimowicz
Journal:  Microb Cell Fact       Date:  2021-05-13       Impact factor: 5.328

4.  A genetic biosensor for identification of transcriptional repressors of target promoters.

Authors:  Weishan Wang; Xiao Li; Yue Li; Shanshan Li; Keqiang Fan; Keqian Yang
Journal:  Sci Rep       Date:  2015-10-29       Impact factor: 4.379

Review 5.  Dithiolopyrrolone natural products: isolation, synthesis and biosynthesis.

Authors:  Zhiwei Qin; Sheng Huang; Yi Yu; Hai Deng
Journal:  Mar Drugs       Date:  2013-10-17       Impact factor: 5.118
  5 in total

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