| Literature DB >> 22504419 |
H Rob Taal1,2,3, Beate St Pourcain4, Elisabeth Thiering5, Shikta Das6, Dennis O Mook-Kanamori1,2,3,7, Nicole M Warrington8,9, Marika Kaakinen10,11, Eskil Kreiner-Møller12, Jonathan P Bradfield13, Rachel M Freathy14, Frank Geller15, Mònica Guxens16,17,18, Diana L Cousminer19, Marjan Kerkhof20, Nicholas J Timpson4, M Arfan Ikram1,21, Lawrence J Beilin22, Klaus Bønnelykke12, Jessica L Buxton23, Pimphen Charoen6,24, Bo Lund Krogsgaard Chawes12, Johan Eriksson25,26,27, David M Evans4, Albert Hofman1,3, John P Kemp4, Cecilia E Kim13, Norman Klopp28,29, Jari Lahti30, Stephen J Lye9, George McMahon4, Frank D Mentch13, Martina Müller31,32,33, Paul F O'Reilly34, Inga Prokopenko35,36, Fernando Rivadeneira1,37, Eric A P Steegers38, Jordi Sunyer16,17,18,39, Carla Tiesler5,40, Hanieh Yaghootkar14, Monique M B Breteler1, Stephanie Debette41, Myriam Fornage42, Vilmundur Gudnason43,44, Lenore J Launer45, Aad van der Lugt21, Thomas H Mosley46, Sudha Seshadri41, Albert V Smith43,44, Meike W Vernooij1,21, Alexandra If Blakemore23, Rosetta M Chiavacci13, Bjarke Feenstra15, Julio Fernandez-Benet47, Struan F A Grant13,48,49, Anna-Liisa Hartikainen50, Albert J van der Heijden2, Carmen Iñiguez18,51, Mark Lathrop52,53, Wendy L McArdle54, Anne Mølgaard12, John P Newnham8, Lyle J Palmer9,55, Aarno Palotie19,56,57,58, Annneli Pouta59, Susan M Ring54, Ulla Sovio6,60, Marie Standl5, Andre G Uitterlinden1,37, H-Erich Wichmann5,31,33, Nadja Hawwa Vissing12, Charles DeCarli61, Cornelia M van Duijn1, Mark I McCarthy35,36,62, Gerard H Koppelman63, Xavier Estivill18,39,64, Andrew T Hattersley65, Mads Melbye15, Hans Bisgaard12, Craig E Pennell8, Elisabeth Widen19, Hakon Hakonarson13,48,49, George Davey Smith4, Joachim Heinrich5, Marjo-Riitta Jarvelin10,59,66, Vincent W V Jaddoe1,2,3.
Abstract
To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 × 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10(-7) for rs7980687 and P = 1.3 × 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22504419 PMCID： PMC3773913 DOI： 10.1038/ng.2238
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330