Literature DB >> 14570040

The role of Notch in tumorigenesis: oncogene or tumour suppressor?

Freddy Radtke1, Kenneth Raj.   

Abstract

Notch signalling participates in the development of multicellular organisms by maintaining the self-renewal potential of some tissues and inducing the differentiation of others. Involvement of Notch in cancer was first highlighted in human T-cell leukaemia, fuelling the notion that aberrant Notch signalling promotes tumorigenesis. However, there is mounting evidence that Notch signalling is not exclusively oncogenic. It can instead function as a tumour suppressor.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 14570040     DOI： 10.1038/nrc1186

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  319 in total

1.  Loss of function, missense, and intronic variants in NOTCH1 confer different risks for left ventricular outflow tract obstructive heart defects in two European cohorts.

Authors:  Emmi Helle; Aldo Córdova-Palomera; Tiina Ojala; Priyanka Saha; Praneetha Potiny; Stefan Gustafsson; Erik Ingelsson; Michael Bamshad; Deborah Nickerson; Jessica X Chong; Euan Ashley; James R Priest
Journal:  Genet Epidemiol       Date:  2018-12-04       Impact factor: 2.135

2.  A pilot phase II study of valproic acid for treatment of low-grade neuroendocrine carcinoma.

Authors:  Tabraiz A Mohammed; Kyle D Holen; Renata Jaskula-Sztul; Daniel Mulkerin; Sam J Lubner; William R Schelman; Jens Eickhoff; Herbert Chen; Noelle K Loconte
Journal:  Oncologist       Date:  2011-05-31

3.  Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells.

Authors:  Sungpil Cho; Meiling Lu; Xiaolong He; Pui-Lai Rachel Ee; Uppoor Bhat; Erasmus Schneider; Lucio Miele; William T Beck
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-05       Impact factor: 11.205

Review 4.  Notch signaling in mammary development and oncogenesis.

Authors:  Robert Callahan; Sean E Egan
Journal:  J Mammary Gland Biol Neoplasia       Date:  2004-04       Impact factor: 2.673

5.  Cortical Oligodendrocytes in Kaolin-Induced Hydrocephalus in Wistar Rat: Impact of Degree and Duration of Ventriculomegaly.

Authors:  Olugbenga Ayodeji Ayannuga; Thajasvarie Naicker
Journal:  Ann Neurosci       Date:  2017-07-24

Review 6.  Myeloma and Bone Disease.

Authors:  Cristina Panaroni; Andrew J Yee; Noopur S Raje
Journal:  Curr Osteoporos Rep       Date:  2017-10       Impact factor: 5.096

Review 7.  Presenilin: RIP and beyond.

Authors:  Matthew R Hass; Chihiro Sato; Raphael Kopan; Guojun Zhao
Journal:  Semin Cell Dev Biol       Date:  2008-11-27       Impact factor: 7.727

Review 8.  Pancreatic cancer stem cells: fact or fiction?

Authors:  Vikash J Bhagwandin; Jerry W Shay
Journal:  Biochim Biophys Acta       Date:  2009-02-21

Review 9.  Pharmacotherapeutic management of pediatric gliomas : current and upcoming strategies.

Authors:  Trent R Hummel; Lionel M Chow; Maryam Fouladi; David Franz
Journal:  Paediatr Drugs       Date:  2013-02       Impact factor: 3.022

10.  Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression.

Authors:  Helen Court; Marc Amoyel; Michael Hackman; Kyoung Eun Lee; Ruliang Xu; George Miller; Dafna Bar-Sagi; Erika A Bach; Martin O Bergö; Mark R Philips
Journal:  J Clin Invest       Date:  2013-11       Impact factor: 14.808
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.