OBJECTIVES: Polymorphic BRCA1 is a vital tumor suppressor gene within the DNA double-strand break repair pathways, but its association with salivary gland carcinoma (SGC) has yet to be investigated. MATERIALS AND METHODS: In a case-control study of 156 SGC patients and 511 controls, we used unconditional logistical regression analyses to investigate the association between SGC risk and seven common functional single-nucleotide polymorphisms (A1988G, A31875G, C33420T, A33921G, A34356G, T43893C and A55298G) in BRCA1. RESULTS: T43893C TC/CC genotype was associated with a reduction of SGC risk (adjusted odds ratio=0.55, 95% CI: 0.38-0.80, Bonferroni-adjusted p=0.011), which was more pronounced in women, non-Hispanic whites, and individuals with a family history of cancer in first-degree relatives. The interaction between T43893C and family history of cancer was significant (p=0.009). The GATGGCG and AACAACA haplotypes, both of which carry the T43893C minor allele, were also associated with reduced SGC risk. CONCLUSION: Our results suggest that polymorphic BRCA1, particularly T43893C polymorphism, may protect against SGC.
OBJECTIVES: Polymorphic BRCA1 is a vital tumor suppressor gene within the DNA double-strand break repair pathways, but its association with salivary gland carcinoma (SGC) has yet to be investigated. MATERIALS AND METHODS: In a case-control study of 156 SGC patients and 511 controls, we used unconditional logistical regression analyses to investigate the association between SGC risk and seven common functional single-nucleotide polymorphisms (A1988G, A31875G, C33420T, A33921G, A34356G, T43893C and A55298G) in BRCA1. RESULTS:T43893C TC/CC genotype was associated with a reduction of SGC risk (adjusted odds ratio=0.55, 95% CI: 0.38-0.80, Bonferroni-adjusted p=0.011), which was more pronounced in women, non-Hispanic whites, and individuals with a family history of cancer in first-degree relatives. The interaction between T43893C and family history of cancer was significant (p=0.009). The GATGGCG and AACAACA haplotypes, both of which carry the T43893C minor allele, were also associated with reduced SGC risk. CONCLUSION: Our results suggest that polymorphic BRCA1, particularly T43893C polymorphism, may protect against SGC.
Authors: R W Pero; D B Johnson; M Markowitz; G Doyle; M Lund-Pero; J Seidegard; M Halper; D G Miller Journal: Carcinogenesis Date: 1989-04 Impact factor: 4.944
Authors: T Saku; Y Hayashi; O Takahara; H Matsuura; M Tokunaga; M Tokunaga; S Tokuoka; M Soda; K Mabuchi; C E Land Journal: Cancer Date: 1997-04-15 Impact factor: 6.860
Authors: Y Miki; J Swensen; D Shattuck-Eidens; P A Futreal; K Harshman; S Tavtigian; Q Liu; C Cochran; L M Bennett; W Ding Journal: Science Date: 1994-10-07 Impact factor: 47.728
Authors: D E Thompson; K Mabuchi; E Ron; M Soda; M Tokunaga; S Ochikubo; S Sugimoto; T Ikeda; M Terasaki; S Izumi Journal: Radiat Res Date: 1994-02 Impact factor: 2.841