| Literature DB >> 22498252 |
Kaiissar Mannoor1, Jipei Liao1, Feng Jiang1.
Abstract
Non-coding RNAs (ncRNAs) are important regulatory molecules involved in various physiological and cellular processes. Alterations of ncRNAs, particularly microRNAs, play crucial roles in tumorigenesis. Accumulating evidence indicates that small nucleolar RNAs (snoRNAs), another large class of small ncRNAs, are gaining prominence and more actively involved in carcinogenesis than previously thought. Some snoRNAs exhibit differential expression patterns in a variety of human cancers and demonstrate capability to affect cell transformation, tumorigenesis, and metastasis. We are beginning to comprehend the functional repercussions of snoRNAs in the development and progression of malignancy. In this review, we will describe current studies that have shed new light on the functions of snoRNAs in carcinogenesis and the potential applications for cancer diagnosis and therapy. Published by Elsevier B.V.Entities:
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Year: 2012 PMID： 22498252 PMCID： PMC3842010 DOI： 10.1016/j.bbcan.2012.03.005
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002