Literature DB >> 22498095

Association of interleukin 1β polymorphisms and haplotypes with Alzheimer's disease.

Spencer Luiz Marques Payão1, Gisela Moraes Gonçalves, Roger William de Labio, Lie Horiguchi, Igor Mizumoto, Lucas Trevizani Rasmussen, Marcela Augusta de Souza Pinhel, Dorotéia Rossi Silva Souza, Marcelo Dib Bechara, Elizabeth Chen, Diego Robles Mazzotti, Paulo Henrique Ferreira Bertolucci, Marília de Arruda Cardoso Smith.   

Abstract

Our study aimed to associate IL-1β and IL-1RN polymorphisms with AD disease in comparison with elderly control group from São Paulo - Brazil. We genotyped 199 Alzheimer's disease (AD) patients, 165 elderly control and 122 young control samples, concerning VNTR (IL-1RN) and -511C>T and -31T>C (IL-1β) polymorphisms. Our findings revealed that -511C/-31T/2-repetitions VNTR haplotype had a protective effect for AD when compared to EC (p=0.005), whereas -511C/-31C/1-repetition VNTR haplotype was associated as a risk factor for AD (p=0.021). Taken together, we may suggest that there is a relevant role of IL-1 genes cluster in AD pathogenesis in this Brazilian population.
Copyright © 2012 Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 22498095     DOI： 10.1016/j.jneuroim.2012.03.012

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


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