BACKGROUND: Differences in the interindividual response to dietary intervention could be modified by genetic variation in nutrient-sensitive genes. OBJECTIVE: This study examined single nucleotide polymorphisms (SNPs) in presumed nutrient-sensitive candidate genes for obesity and obesity-related diseases for main and dietary interaction effects on weight, waist circumference, and fat mass regain over 6 mo. DESIGN: In total, 742 participants who had lost ≥ 8% of their initial body weight were randomly assigned to follow 1 of 5 different ad libitum diets with different glycemic indexes and contents of dietary protein. The SNP main and SNP-diet interaction effects were analyzed by using linear regression models, corrected for multiple testing by using Bonferroni correction and evaluated by using quantile-quantile (Q-Q) plots. RESULTS: After correction for multiple testing, none of the SNPs were significantly associated with weight, waist circumference, or fat mass regain. Q-Q plots showed that ALOX5AP rs4769873 showed a higher observed than predicted P value for the association with less waist circumference regain over 6 mo (-3.1 cm/allele; 95% CI: -4.6, -1.6; P/Bonferroni-corrected P = 0.000039/0.076), independently of diet. Additional associations were identified by using Q-Q plots for SNPs in ALOX5AP, TNF, and KCNJ11 for main effects; in LPL and TUB for glycemic index interaction effects on waist circumference regain; in GHRL, CCK, MLXIPL, and LEPR on weight; in PPARC1A, PCK2, ALOX5AP, PYY, and ADRB3 on waist circumference; and in PPARD, FABP1, PLAUR, and LPIN1 on fat mass regain for dietary protein interaction. CONCLUSION: The observed effects of SNP-diet interactions on weight, waist, and fat mass regain suggest that genetic variation in nutrient-sensitive genes can modify the response to diet. This trial was registered at clinicaltrials.gov as NCT00390637.
RCT Entities:
BACKGROUND: Differences in the interindividual response to dietary intervention could be modified by genetic variation in nutrient-sensitive genes. OBJECTIVE: This study examined single nucleotide polymorphisms (SNPs) in presumed nutrient-sensitive candidate genes for obesity and obesity-related diseases for main and dietary interaction effects on weight, waist circumference, and fat mass regain over 6 mo. DESIGN: In total, 742 participants who had lost ≥ 8% of their initial body weight were randomly assigned to follow 1 of 5 different ad libitum diets with different glycemic indexes and contents of dietary protein. The SNP main and SNP-diet interaction effects were analyzed by using linear regression models, corrected for multiple testing by using Bonferroni correction and evaluated by using quantile-quantile (Q-Q) plots. RESULTS: After correction for multiple testing, none of the SNPs were significantly associated with weight, waist circumference, or fat mass regain. Q-Q plots showed that ALOX5APrs4769873 showed a higher observed than predicted P value for the association with less waist circumference regain over 6 mo (-3.1 cm/allele; 95% CI: -4.6, -1.6; P/Bonferroni-corrected P = 0.000039/0.076), independently of diet. Additional associations were identified by using Q-Q plots for SNPs in ALOX5AP, TNF, and KCNJ11 for main effects; in LPL and TUB for glycemic index interaction effects on waist circumference regain; in GHRL, CCK, MLXIPL, and LEPR on weight; in PPARC1A, PCK2, ALOX5AP, PYY, and ADRB3 on waist circumference; and in PPARD, FABP1, PLAUR, and LPIN1 on fat mass regain for dietary protein interaction. CONCLUSION: The observed effects of SNP-diet interactions on weight, waist, and fat mass regain suggest that genetic variation in nutrient-sensitive genes can modify the response to diet. This trial was registered at clinicaltrials.gov as NCT00390637.
Authors: Mikkel Z Ankarfeldt; Sofus C Larsen; Lars Ängquist; Lise Lotte N Husemoen; Nina Roswall; Kim Overvad; Marianne Uhre Jakobsen; Jytte Halkjær; Anne Tjønneland; Allan Linneberg; Ulla Toft; Torben Hansen; Oluf Pedersen; Berit L Heitmann; Arne Astrup; Thorkild I A Sørensen Journal: PLoS One Date: 2014-10-28 Impact factor: 3.240
Authors: Karina Meidtner; Eva Fisher; Lars Angquist; Claus Holst; Karani S Vimaleswaran; Jolanda M A Boer; Jytte Halkjær; Giovanna Masala; Jane N Ostergaard; Lotte M Mortensen; Daphne L van der A; Anne Tjønneland; Domenico Palli; Kim Overvad; Nicholas J Wareham; Ruth J F Loos; Thorkild I A Sørensen; Heiner Boeing Journal: Genes Nutr Date: 2014-02-05 Impact factor: 5.523
Authors: Katherine M Livingstone; Carlos Celis-Morales; George D Papandonatos; Bahar Erar; Jose C Florez; Kathleen A Jablonski; Cristina Razquin; Amelia Marti; Yoriko Heianza; Tao Huang; Frank M Sacks; Mathilde Svendstrup; Xuemei Sui; Timothy S Church; Tiina Jääskeläinen; Jaana Lindström; Jaakko Tuomilehto; Matti Uusitupa; Tuomo Rankinen; Wim H M Saris; Torben Hansen; Oluf Pedersen; Arne Astrup; Thorkild I A Sørensen; Lu Qi; George A Bray; Miguel A Martinez-Gonzalez; J Alfredo Martinez; Paul W Franks; Jeanne M McCaffery; Jose Lara; John C Mathers Journal: BMJ Date: 2016-09-20