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Literature DB >> 224808

Preliminary studies of the mode of action of arildone, a novel antiviral agent.

M F Kuhrt, M J Fancher, V Jasty, F Pancic, P E Came.

Abstract

Arildone (also known as Win 38020), a novel aryl diketone, inhibited replication of herpes simplex virus type 2 in tissue culture by interfering with an event that occurs prior to 6 h postinfection. The inhibition could be partially reversed by washing. Although the exact mechanism of action is unknown, neither viral deoxyribonucleic acid nor viral proteins were synthesized in the presence of arildone.

Entities: Chemical Species

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Year: 1979 PMID： 224808 PMCID： PMC352764 DOI： 10.1128/AAC.15.6.813

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

12 in total

1. SOME CHARACTERISTICS OF THE DEOXYRIBONUCLEIC ACID FROM HERPES SIMPLEX VIRUS.

Authors: W C RUSSELL; L V CRAWFORD
Journal: Virology Date: 1963-11 Impact factor: 3.616

2. A simple membrane fractionation method for determining the distribution of radioactivity in chemical fractions of Bacillus cereus.

Authors: D B ROODYN; H G MANDEL
Journal: Biochim Biophys Acta Date: 1960-06-17

3. Inhibition of herpes simplex virus replication by phosphonoacetic acid.

Authors: L R Overby; E E Robishaw; J B Schleicher; A Rueter; N L Shipkowitz; J C Mao
Journal: Antimicrob Agents Chemother Date: 1974-09 Impact factor: 5.191

4. Herpes simplex virus and human cytomegalovirus replication in WI-38 cells. I. Sequence of viral replication.

Authors: J D Smith; E De Harven
Journal: J Virol Date: 1973-10 Impact factor: 5.103

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Authors: R W Darlington; L H Moss
Journal: J Virol Date: 1968-01 Impact factor: 5.103

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Authors: C Morgan; H M Rose; B Mednis
Journal: J Virol Date: 1968-05 Impact factor: 5.103

7. Electron microscopy of herpes simplex virus. II. Sequence of development.

Authors: S Nii; C Morgan; H M Rose
Journal: J Virol Date: 1968-05 Impact factor: 5.103

Review 8. The envelope of Herpesvirus.

Authors: R W Darlington; L H Moss
Journal: Prog Med Virol Date: 1969

9. Antiviral activity of some beta-diketones. 2. Aryloxy alkyl diketones. In vitro activity against both RNA and DNA viruses.

Authors: G D Diana; U J Salvador; E S Zalay; P M Carabateas; G L Williams; J C Collins; F Pancic
Journal: J Med Chem Date: 1977-06 Impact factor: 7.446

10. Proteins specified by herpes simplex virus. XII. The virion polypeptides of type 1 strains.

Authors: J W Heine; R W Honess; E Cassai; B Roizman
Journal: J Virol Date: 1974-09 Impact factor: 5.103

8 in total

1. Activity of 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (MDL-860) against picornaviruses in vitro.

Authors: R D Powers; J M Gwaltney; F G Hayden
Journal: Antimicrob Agents Chemother Date: 1982-10 Impact factor: 5.191

2. Antiviral activity of Win 41258-3, a pyrazole compound, against herpes simplex virus in mouse genital infection and in guinea pig skin infection.

Authors: F Pancic; B A Steinberg; G D Diana; P M Carabateas; W G Gorman; P E Came
Journal: Antimicrob Agents Chemother Date: 1981-03 Impact factor: 5.191

Review 8. Picornavirus inhibitors.

Authors: L Carrasco
Journal: Pharmacol Ther Date: 1994 Impact factor: 12.310