BACKGROUND: A recent study suggested a markedly increased risk of hepatoblastoma (HB) among children conceived with treatment for infertility. However, it is not clear whether this finding is confounded by the association between HB and low birthweight (LBW). METHODS: Associations between parental infertility and its treatment and HB were examined using data from a case-control study conducted through the Children's Oncology Group (COG). Telephone interviews were completed for 383 mothers of cases diagnosed with HB at US COG institutions between January 2000 and December 2008 and for 387 mothers of controls recruited through state birth registries. Logistic regression was used to examine possible associations. RESULTS: After adjusting for birthweight and other potential confounders, no significant association was found for any of the measures of parental infertility or its treatment. In HB cases conceived through assisted reproductive technology (ART), 4 of 16 also had Beckwith-Wiedemann syndrome (BWS) compared with 9 of 365 in HB cases without ART. CONCLUSIONS: Little evidence of an association between parental infertility or its treatment and HB was found. The relationship found in a previous study could be due to LBW and BWS which are risk factors for HB and also associated with parental infertility and its treatment.
BACKGROUND: A recent study suggested a markedly increased risk of hepatoblastoma (HB) among children conceived with treatment for infertility. However, it is not clear whether this finding is confounded by the association between HB and low birthweight (LBW). METHODS: Associations between parental infertility and its treatment and HB were examined using data from a case-control study conducted through the Children's Oncology Group (COG). Telephone interviews were completed for 383 mothers of cases diagnosed with HB at US COG institutions between January 2000 and December 2008 and for 387 mothers of controls recruited through state birth registries. Logistic regression was used to examine possible associations. RESULTS: After adjusting for birthweight and other potential confounders, no significant association was found for any of the measures of parental infertility or its treatment. In HB cases conceived through assisted reproductive technology (ART), 4 of 16 also had Beckwith-Wiedemann syndrome (BWS) compared with 9 of 365 in HB cases without ART. CONCLUSIONS: Little evidence of an association between parental infertility or its treatment and HB was found. The relationship found in a previous study could be due to LBW and BWS which are risk factors for HB and also associated with parental infertility and its treatment.
Authors: Greta R Bunin; Logan G Spector; Andrew F Olshan; Leslie L Robison; Michelle Roesler; Seymour Grufferman; Xiao-ou Shu; Julie A Ross Journal: Am J Epidemiol Date: 2007-04-23 Impact factor: 4.897
Authors: A G Sutcliffe; C J Peters; S Bowdin; K Temple; W Reardon; L Wilson; J Clayton-Smith; L A Brueton; W Bannister; E R Maher Journal: Hum Reprod Date: 2005-12-16 Impact factor: 6.918
Authors: S Rossignol; V Steunou; C Chalas; A Kerjean; M Rigolet; E Viegas-Pequignot; P Jouannet; Y Le Bouc; C Gicquel Journal: J Med Genet Date: 2006-07-06 Impact factor: 6.318
Authors: Marianne E Doornbos; Saskia M Maas; Joseph McDonnell; Jan P W Vermeiden; Raoul C M Hennekam Journal: Hum Reprod Date: 2007-06-23 Impact factor: 6.918
Authors: Logan G Spector; Julie A Ross; Susan E Puumala; Michelle Roesler; Andrew F Olshan; Greta R Bunin Journal: Am J Epidemiol Date: 2007-07-10 Impact factor: 4.897
Authors: Susan E Puumala; Julie A Ross; Andrew F Olshan; Leslie L Robison; Franklin O Smith; Logan G Spector Journal: Cancer Date: 2007-11-01 Impact factor: 6.860
Authors: Lucie M Turcotte; Michael K Georgieff; Julie A Ross; James H Feusner; Gail E Tomlinson; Marcio H Malogolowkin; Mark D Krailo; Nicole Miller; Rachel Fonstad; Logan G Spector Journal: Pediatr Blood Cancer Date: 2014-07-15 Impact factor: 3.167
Authors: Kimberly J Johnson; Katherine S Williams; Julie A Ross; Mark D Krailo; Gail E Tomlinson; Marcio H Malogolowkin; James H Feusner; Logan G Spector Journal: Cancer Epidemiol Biomarkers Prev Date: 2013-08-15 Impact factor: 4.254
Authors: Rajkumar Venkatramani; Logan G Spector; Michael Georgieff; Gail Tomlinson; Mark Krailo; Marcio Malogolowkin; Wendy Kohlmann; Karen Curtin; Rachel K Fonstad; Joshua D Schiffman Journal: Am J Med Genet A Date: 2014-06-16 Impact factor: 2.802