Literature DB >> 22472987

Interpatient pharmacokinetic and pharmacodynamic variability of carrier-mediated anticancer agents.

W P Caron1, G Song, P Kumar, S Rawal, W C Zamboni.   

Abstract

Major advances in the field of carrier-mediated agents (CMAs) have revolutionized drug delivery capabilities over the past decade. While providing numerous advantages over their small-molecule counterparts (solubility,duration of exposure, and delivery to the site of action are higher), these agents display substantial variability in systemic clearance (CL) and distribution, tumor delivery, and pharmacologic effects. This review provides an overview of factors that affect the pharmacokinetics (PK) and pharmacodynamics (PD) of CMAs in preclinical models and patients.

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Year:  2012        PMID： 22472987     DOI： 10.1038/clpt.2012.12

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  26 in total

Review 1.  Unintended effects of drug carriers: Big issues of small particles.

Authors:  Hamideh Parhiz; Makan Khoshnejad; Jacob W Myerson; Elizabeth Hood; Priyal N Patel; Jacob S Brenner; Vladimir R Muzykantov
Journal:  Adv Drug Deliv Rev       Date:  2018-07-03       Impact factor: 15.470

2.  Liposome-induced immunosuppression and tumor growth is mediated by macrophages and mitigated by liposome-encapsulated alendronate.

Authors:  Robin Rajan; Manoj K Sabnani; Vikram Mavinkurve; Hilary Shmeeda; Hossein Mansouri; Sandrine Bonkoungou; Alexander D Le; Laurence M Wood; Alberto A Gabizon; Ninh M La-Beck
Journal:  J Control Release       Date:  2017-12-23       Impact factor: 9.776

Review 3.  Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior.

Authors:  Miles A Miller; Ralph Weissleder
Journal:  Adv Drug Deliv Rev       Date:  2016-06-04       Impact factor: 15.470

4.  Evaluation of the efficiency of tumor and tissue delivery of carrier-mediated agents (CMA) and small molecule (SM) agents in mice using a novel pharmacokinetic (PK) metric: relative distribution index over time (RDI-OT).

Authors:  Andrew J Madden; Sumit Rawal; Katie Sandison; Ryan Schell; Allison Schorzman; Allison Deal; Lan Feng; Ping Ma; Russell Mumper; Joseph DeSimone; William C Zamboni
Journal:  J Nanopart Res       Date:  2014-11-01       Impact factor: 2.253

5.  Macrophage silica nanoparticle response is phenotypically dependent.

Authors:  Heather L Herd; Kristopher T Bartlett; Joshua A Gustafson; Lawrence D McGill; Hamidreza Ghandehari
Journal:  Biomaterials       Date:  2015-03-23       Impact factor: 12.479

6.  Insights into accelerated liposomal release of topotecan in plasma monitored by a non-invasive fluorescence spectroscopic method.

Authors:  Kyle D Fugit; Amar Jyoti; Meenakshi Upreti; Bradley D Anderson
Journal:  J Control Release       Date:  2014-10-25       Impact factor: 9.776

7.  Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models.

Authors:  Gina Song; David B Darr; Charlene M Santos; Mark Ross; Alain Valdivia; Jamie L Jordan; Bentley R Midkiff; Stephanie Cohen; Nana Nikolaishvili-Feinberg; C Ryan Miller; Teresa K Tarrant; Arlin B Rogers; Andrew C Dudley; Charles M Perou; William C Zamboni
Journal:  Clin Cancer Res       Date:  2014-09-17       Impact factor: 12.531

8.  Translational studies of phenotypic probes for the mononuclear phagocyte system and liposomal pharmacology.

Authors:  Whitney P Caron; John C Lay; Alan M Fong; Ninh M La-Beck; Parag Kumar; Suzanne E Newman; Haibo Zhou; Jane H Monaco; Daniel L Clarke-Pearson; Wendy R Brewster; Linda Van Le; Victoria L Bae-Jump; Paola A Gehrig; William C Zamboni
Journal:  J Pharmacol Exp Ther       Date:  2013-09-16       Impact factor: 4.030

9.  Functional-segregated coumarin-containing telodendrimer nanocarriers for efficient delivery of SN-38 for colon cancer treatment.

Authors:  Gaofei Xu; Changying Shi; Dandan Guo; Lili Wang; Yun Ling; Xiaobing Han; Juntao Luo
Journal:  Acta Biomater       Date:  2015-04-22       Impact factor: 8.947

10.  Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology.

Authors:  Uma Prabhakar; Hiroshi Maeda; Rakesh K Jain; Eva M Sevick-Muraca; William Zamboni; Omid C Farokhzad; Simon T Barry; Alberto Gabizon; Piotr Grodzinski; David C Blakey
Journal:  Cancer Res       Date:  2013-02-19       Impact factor: 12.701
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