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Literature DB >> 22467201

Effect of some pyrimidine compounds on rat brain monoamine oxidase-B in vitro.

Nadia Z Shaban¹, Mamdouh S Masoud, Mai A Mawlawi, Doaa Awad, Omayma M Sadek.

Abstract

The effects of some pyrimidine compounds (PCs) including barbituric acid (BA) 5,5-diethyl barbituric acid (DEBA), 2-thiobarbituric acid (TBA), violuric acid (VA), 2-thiouracil (TU), and 6-amino-2-thiouracil (ATU) on the activity of rat brain monoamine oxidase-B (MAO-B) were investigated. The results revealed that MAO-B was activated by BA, DEBA, TBA, TU, and ATU, and the activation was structural, concentration, and time dependent. However, MAO-B was inhibited by VA in a noncompetitive and irreversible manner with an enzyme-inhibitor dissociation constant (K (i) value) of 32 nM and IC(50) equals to 19 nM. All the studied PCs changed both the optimum pH and temperature of MAO-B.

Entities: Chemical Gene Species

Mesh：

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Year: 2012 PMID： 22467201 DOI： 10.1007/s13105-012-0160-4

Source DB: PubMed Journal: J Physiol Biochem ISSN： 1138-7548 Impact factor: 4.158

31 in total

1. The inhibition of monoamine oxidase by brofaromine.

Authors: M C Anderson; P C Waldmeier; K F Tipton
Journal: Biochem Pharmacol Date: 1991-06-15 Impact factor: 5.858

2. cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties.

Authors: A W Bach; N C Lan; D L Johnson; C W Abell; M E Bembenek; S W Kwan; P H Seeburg; J C Shih
Journal: Proc Natl Acad Sci U S A Date: 1988-07 Impact factor: 11.205

3. Topographic immunocytochemical mapping of monoamine oxidase-A, monoamine oxidase-B and tyrosine hydroxylase in human post mortem brain stem.

Authors: C Konradi; E Svoma; K Jellinger; P Riederer; R Denney; J Thibault
Journal: Neuroscience Date: 1988-09 Impact factor: 3.590

1. Microwave assisted synthesis of some new thiazolopyrimidine and pyrimidothiazolopyrimidopyrimidine derivatives with potential antimicrobial activity.

Authors: Ayman M S Youssef; Ahmed M Fouda; Rasha M Faty
Journal: Chem Cent J Date: 2018-05-05 Impact factor: 4.215

1 in total

Effect of some pyrimidine compounds on rat brain monoamine oxidase-B in vitro.

1. The inhibition of monoamine oxidase by brofaromine.

2. cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties.

3. Topographic immunocytochemical mapping of monoamine oxidase-A, monoamine oxidase-B and tyrosine hydroxylase in human post mortem brain stem.

4. MAO inhibitors and oxidant stress in aging brain tissue.

5. New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors.

6. Inhibition of monoamine oxidase activity by cannabinoids.

7. Chalcones: a valid scaffold for monoamine oxidases inhibitors.

8. Inhibition of monoamine oxidase B by N-methyl-2-phenylmaleimides.

Review 9. Monoamine oxidase inactivation: from pathophysiology to therapeutics.

Review 10. Progress in monoamine oxidase (MAO) research in relation to genetic engineering.

1. Microwave assisted synthesis of some new thiazolopyrimidine and pyrimidothiazolopyrimidopyrimidine derivatives with potential antimicrobial activity.