BACKGROUND: Transplantation of kidneys retrieved from extended criteria donors is one of the options to expand the pool of available grafts, shorten the waiting time and increase the availability of this method of treatment. However, some factors (eg, donor age) may impair the results of transplantation. MATERIAL/ METHODS: This study was a retrospective assessment of 327 patients who underwent renal transplants during the period 1995-2005, with kidneys harvested from expanded criteria donors (ECD) as defined by the United Network for Organ Sharing (UNOS). They formed 2 groups: group 1 (ECD - younger, n=255) consisted of recipients of kidneys obtained from donors aged 50-59 years; group 2 (ECD - older, n=72) consisted of patients who received kidneys from donors ≥ 60 years old. An analysis of the 1-, 3- and 5-year survival of grafts and patients and evaluation of graft function were performed. RESULTS: graft survival was significantly better in group 1 (ECD-younger) vs. group 2 (ECD-older), as was renal graft function. Survival 3 and 5 years after transplantation was 87.7% vs. 81.9%, 73.1% vs. 66.6%, and 60.1% vs. 51.7%, respectively. Delayed graft function occurred significantly more frequently in group 2 (group 1 vs. group 2-28.8% vs. 34.6%, p=0.0001). CONCLUSIONS: The transplantation of kidneys obtained from older donors fulfilling ECD definition is associated with shorter graft survival, deteriorated function and more frequent renal delayed graft function. However, this did not increase the mortality of recipients.
BACKGROUND: Transplantation of kidneys retrieved from extended criteria donors is one of the options to expand the pool of available grafts, shorten the waiting time and increase the availability of this method of treatment. However, some factors (eg, donor age) may impair the results of transplantation. MATERIAL/ METHODS: This study was a retrospective assessment of 327 patients who underwent renal transplants during the period 1995-2005, with kidneys harvested from expanded criteria donors (ECD) as defined by the United Network for Organ Sharing (UNOS). They formed 2 groups: group 1 (ECD - younger, n=255) consisted of recipients of kidneys obtained from donors aged 50-59 years; group 2 (ECD - older, n=72) consisted of patients who received kidneys from donors ≥ 60 years old. An analysis of the 1-, 3- and 5-year survival of grafts and patients and evaluation of graft function were performed. RESULTS: graft survival was significantly better in group 1 (ECD-younger) vs. group 2 (ECD-older), as was renal graft function. Survival 3 and 5 years after transplantation was 87.7% vs. 81.9%, 73.1% vs. 66.6%, and 60.1% vs. 51.7%, respectively. Delayed graft function occurred significantly more frequently in group 2 (group 1 vs. group 2-28.8% vs. 34.6%, p=0.0001). CONCLUSIONS: The transplantation of kidneys obtained from older donors fulfilling ECD definition is associated with shorter graft survival, deteriorated function and more frequent renal delayed graft function. However, this did not increase the mortality of recipients.
Authors: Luciana Assis-Borba; Marina P Cristelli; Mayara I Paula; Marcelo F Franco; Helio Tedesco-Silva; Jose O Medina-Pestana Journal: Int Urol Nephrol Date: 2014-03-28 Impact factor: 2.370
Authors: Samuel J Tingle; Rodrigo S Figueiredo; John Ag Moir; Michael Goodfellow; David Talbot; Colin H Wilson Journal: Cochrane Database Syst Rev Date: 2019-03-15
Authors: Matteo Ravaioli; Maurizio Baldassare; Francesco Vasuri; Gianandrea Pasquinelli; Maristella Laggetta; Sabrina Valente; Vanessa De Pace; Flavia Neri; Antonio Siniscalchi; Chiara Zanfi; Valentina R Bertuzzo; Paolo Caraceni; Davide Trerè; Pasquale Longobardi; Antonio D Pinna Journal: Ann Transplant Date: 2018-01-12 Impact factor: 1.530
Authors: Matteo Ravaioli; Vanessa De Pace; Andrea Angeletti; Giorgia Comai; Francesco Vasuri; Maurizio Baldassarre; Lorenzo Maroni; Federica Odaldi; Guido Fallani; Paolo Caraceni; Giuliana Germinario; Chiara Donadei; Deborah Malvi; Massimo Del Gaudio; Valentina Rosa Bertuzzo; Antonio Siniscalchi; Vito Marco Ranieri; Antonietta D'Errico; Gianandrea Pasquinelli; Maria Cristina Morelli; Antonio Daniele Pinna; Matteo Cescon; Gaetano La Manna Journal: Sci Rep Date: 2020-04-08 Impact factor: 4.379