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Literature DB >> 22465829

Metformin and pancreatic cancer: a clue requiring investigation.

Abstract

Laboratory models show antineoplastic activity of metformin under certain conditions, and pharmacoepidemiologic studies have reported reduced cancer burden among diabetics taking metformin. Therefore, the hypothesis that metformin has antineoplastic activity is receiving increasing attention. However, gaps in knowledge must be addressed before metformin can be "repurposed" for oncologic indications. ©2012 AACR.

Entities: Chemical Disease

Mesh：

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Year: 2012 PMID： 22465829 DOI： 10.1158/1078-0432.CCR-12-0694

Source DB: PubMed Journal: Clin Cancer Res ISSN： 1078-0432 Impact factor: 12.531

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Cited

14 in total

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Authors: Michael Pollak
Journal: Diabetologia Date: 2017-08-02 Impact factor: 10.122

Review 2. Minireview: the year in obesity and cancer.

Authors: Stephen D Hursting
Journal: Mol Endocrinol Date: 2012-10-09

3. Melatonin and Metformin Failed to Modify the Effect of Dacarbazine in Melanoma.

Authors: Aleksei Viktorovich Novik; Svetlana Anatolievna Protsenko; Irina Alexandrovna Baldueva; Lev Michailovich Berstein; Vladimir Nikolaevich Anisimov; Irina Nikolaevna Zhuk; Anna Igorevna Semenova; Dilorom Khamidovna Latipova; Elena Viktorovna Tkachenko; Tatiana Yurievna Semiglazova
Journal: Oncologist Date: 2021-04-09

4. Diabetes mellitus type 2 drives metabolic reprogramming to promote pancreatic cancer growth.

Authors: Guermarie Velazquez-Torres; Enrique Fuentes-Mattei; Hyun Ho Choi; Sai-Ching J Yeung; Xiangqi Meng; Mong-Hong Lee
Journal: Gastroenterol Rep (Oxf) Date: 2020-05-27

5. Metformin use among type 2 diabetics and risk of pancreatic cancer in a clinic-based case-control study.

Authors: Evan J Walker; Andrew H Ko; Elizabeth A Holly; Paige M Bracci
Journal: Int J Cancer Date: 2014-08-14 Impact factor: 7.396

Review 6. Current and future systemic treatment options in metastatic pancreatic cancer.

Authors: Cagatay Arslan; Suayib Yalcin
Journal: J Gastrointest Oncol Date: 2014-08

7. Contextual inhibition of fatty acid synthesis by metformin involves glucose-derived acetyl-CoA and cholesterol in pancreatic tumor cells.

Authors: Mary Jo Cantoria; László G Boros; Emmanuelle J Meuillet
Journal: Metabolomics Date: 2013-06-26 Impact factor: 4.290