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Literature DB >> 28770326

The effects of metformin on gut microbiota and the immune system as research frontiers.

Abstract

Recent studies have revealed that metformin influences gut microbiota and the immune system although neither is a classic target of the drug. This research has revealed complexity not previously appreciated, and opened new research directions. The extent to which immunomodulatory effects and actions on the microbiota are related to each other and account for effects on host energy metabolism remains to be determined. These sites of action may be relevant not only to the efficacy of metformin for its established use in type 2 diabetes, but also to proposed novel indications in oncology and other diseases.

Entities: Chemical Disease

Keywords: Diabetes; Metformin; Microbiome; Microbiota immunity cancer

Mesh：

Substances：
Metformin

Year: 2017 PMID： 28770326 DOI： 10.1007/s00125-017-4352-x

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

53 in total

1. Metformin: historical overview.

Authors: Clifford J Bailey
Journal: Diabetologia Date: 2017-08-03 Impact factor: 10.122

2. Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin.

Authors: N V Rajeshkumar; Shinichi Yabuuchi; Shweta G Pai; Elizabeth De Oliveira; Jurre J Kamphorst; Joshua D Rabinowitz; Héctor Tejero; Fátima Al-Shahrour; Manuel Hidalgo; Anirban Maitra; Chi V Dang
Journal: Clin Cancer Res Date: 2017-06-13 Impact factor: 12.531

Review 3. Investigating metformin for cancer prevention and treatment: the end of the beginning.

Authors: Michael N Pollak
Journal: Cancer Discov Date: 2012-08-27 Impact factor: 39.397

Review 4. The Role of the Immune System in Metabolic Health and Disease.

Authors: Niv Zmora; Stavros Bashiardes; Maayan Levy; Eran Elinav
Journal: Cell Metab Date: 2017-03-07 Impact factor: 27.287

5. A metagenome-wide association study of gut microbiota in type 2 diabetes.

Authors: Junjie Qin; Yingrui Li; Zhiming Cai; Shenghui Li; Jianfeng Zhu; Fan Zhang; Suisha Liang; Wenwei Zhang; Yuanlin Guan; Dongqian Shen; Yangqing Peng; Dongya Zhang; Zhuye Jie; Wenxian Wu; Youwen Qin; Wenbin Xue; Junhua Li; Lingchuan Han; Donghui Lu; Peixian Wu; Yali Dai; Xiaojuan Sun; Zesong Li; Aifa Tang; Shilong Zhong; Xiaoping Li; Weineng Chen; Ran Xu; Mingbang Wang; Qiang Feng; Meihua Gong; Jing Yu; Yanyan Zhang; Ming Zhang; Torben Hansen; Gaston Sanchez; Jeroen Raes; Gwen Falony; Shujiro Okuda; Mathieu Almeida; Emmanuelle LeChatelier; Pierre Renault; Nicolas Pons; Jean-Michel Batto; Zhaoxi Zhang; Hua Chen; Ruifu Yang; Weimou Zheng; Songgang Li; Huanming Yang; Jian Wang; S Dusko Ehrlich; Rasmus Nielsen; Oluf Pedersen; Karsten Kristiansen; Jun Wang
Journal: Nature Date: 2012-09-26 Impact factor: 49.962

Review 6. Metformin: from mechanisms of action to therapies.

Authors: Marc Foretz; Bruno Guigas; Luc Bertrand; Michael Pollak; Benoit Viollet
Journal: Cell Metab Date: 2014-10-30 Impact factor: 27.287

7. Metformin as adjunct antituberculosis therapy.

Authors: Amit Singhal; Liu Jie; Pavanish Kumar; Gan Suay Hong; Melvin Khee-Shing Leow; Bhairav Paleja; Liana Tsenova; Natalia Kurepina; Jinmiao Chen; Francesca Zolezzi; Barry Kreiswirth; Michael Poidinger; Cynthia Chee; Gilla Kaplan; Yee Tang Wang; Gennaro De Libero
Journal: Sci Transl Med Date: 2014-11-19 Impact factor: 17.956

8. Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis.

Authors: Laura Negrotto; Mauricio F Farez; Jorge Correale
Journal: JAMA Neurol Date: 2016-05-01 Impact factor: 18.302

Review 9. Cancer, obesity, diabetes, and antidiabetic drugs: is the fog clearing?

Authors: Adi J Klil-Drori; Laurent Azoulay; Michael N Pollak
Journal: Nat Rev Clin Oncol Date: 2016-08-09 Impact factor: 66.675

Review 10. Metformin and the gastrointestinal tract.

Authors: Laura J McCreight; Clifford J Bailey; Ewan R Pearson
Journal: Diabetologia Date: 2016-01-16 Impact factor: 10.122

33 in total

1. 60 years of metformin use: a glance at the past and a look to the future.

Authors: Sally M Marshall
Journal: Diabetologia Date: 2017-09 Impact factor: 10.122

2. Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells.

Authors: Xingyu Wu; Huwate Yeerna; Yusuke Goto; Toshinori Ando; Victoria H Wu; Xuefeng Zhang; Zhiyong Wang; Panomwat Amornphimoltham; Anne N Murphy; Pablo Tamayo; Qianming Chen; Scott M Lippman; J Silvio Gutkind
Journal: Cancer Res Date: 2019-07-10 Impact factor: 12.701

3. Long-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study.

Authors: John W Apolzan; Elizabeth M Venditti; Sharon L Edelstein; William C Knowler; Dana Dabelea; Edward J Boyko; Xavier Pi-Sunyer; Rita R Kalyani; Paul W Franks; Preethi Srikanthan; Kishore M Gadde
Journal: Ann Intern Med Date: 2019-04-23 Impact factor: 25.391

4. Recommendations for Practical Use of Metformin, a Central Pharmacological Therapy in Type 2 Diabetes.

Authors: Inês H Vieira; Luísa M Barros; Carla F Baptista; Dírcea M Rodrigues; Isabel M Paiva
Journal: Clin Diabetes Date: 2022-01

Review 5. Contribution to Tumor Angiogenesis From Innate Immune Cells Within the Tumor Microenvironment: Implications for Immunotherapy.

Authors: Adriana Albini; Antonino Bruno; Douglas M Noonan; Lorenzo Mortara
Journal: Front Immunol Date: 2018-04-05 Impact factor: 7.561