Radiological diagnostic progress in skeletal diseases.

High-resolution bone imaging has made tremendous progress in the recent past. Both imaging modalities, computed tomography as well as MR imaging, have improved image quality. New developments such as HR-pQCT now make it possible to acquire in vivo images at peripheral sites with isotropic voxel size in a very short time. Further enhancements in the MR field have made it possible to image more central body sites such as the proximal femur with very high spatial resolution. New analysis methods can obtain direct estimates of biomechanical properties and important information related to bone's topology, as well as parameters of scale and orientation. These accomplishments will be essential in the noninvasive assessment of osteoporosis and fracture risk, will provide insight into the mechanisms behind bone loss, and will increasingly play a role as a tool for assessing treatment efficacy.