Play and players in bone fracture healing match.

Bone fractured healing is a specialized wound-healing response that leads to regeneration without scar restoring its own ability of mechanical loading. The four stage classification of fracture healing process, by John Hunter, is still the frame in which the new biological and molecular findings settle in.Nowadays the fracture healing is pictured like a playground where growth and differentiation factors, hormones, cytokines, and extracellular matrix play with bone and cartilage forming primary cells and muscle mesenchymal cells in a well orchestrated series of biological events. The ongoing knowledge of cellular and molecular interactions between blood vessels and bone cells shows great promise to enhance fracture management and the unsuccessfull process of bone healing.