Literature DB >> 20709627

Contemporary human genetic strategies in aging research.

Cinnamon S Bloss1, Ludmila Pawlikowska, Nicholas J Schork.   

Abstract

Human aging is a complex, multifactorial process influenced by a number of genetic and non-genetic factors. This article first reviews genetic strategies for human aging research and considers the advantages and disadvantages of each. We then discuss the issue of phenotypic definition for genetic studies of aging, including longevity/life span, as well as disease-free survival and other endophenotypes. Finally, we argue that extensions of this area of research, including incorporation of gene×environment interactions, multivariate phenotypes, integration of functional genomic annotations, and exploitation of orthology - many of which are already initiated and ongoing - are critical to advancing this field.
Copyright © 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20709627      PMCID： PMC3043164          DOI： 10.1016/j.arr.2010.07.005

Source DB:  PubMed          Journal:  Ageing Res Rev        ISSN： 1568-1637            Impact factor:   10.895


  63 in total

1.  Genomics: journey to the center of biology.

Authors:  E S Lander; R A Weinberg
Journal:  Science       Date:  2000-03-10       Impact factor: 47.728

2.  Does higher concordance in monozygotic twins than in dizygotic twins suggest a genetic component?

Authors:  S W Guo
Journal:  Hum Hered       Date:  2001       Impact factor: 0.444

3.  Inheritance of human longevity in Iceland.

Authors:  H Gudmundsson; D F Gudbjartsson; M Frigge; J R Gulcher; K Stefánsson
Journal:  Eur J Hum Genet       Date:  2000-10       Impact factor: 4.246

4.  A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.

Authors:  Anne B Newman; Stefan Walter; Kathryn L Lunetta; Melissa E Garcia; P Eline Slagboom; Kaare Christensen; Alice M Arnold; Thor Aspelund; Yurii S Aulchenko; Emelia J Benjamin; Lene Christiansen; Ralph B D'Agostino; Annette L Fitzpatrick; Nora Franceschini; Nicole L Glazer; Vilmundur Gudnason; Albert Hofman; Robert Kaplan; David Karasik; Margaret Kelly-Hayes; Douglas P Kiel; Lenore J Launer; Kristin D Marciante; Joseph M Massaro; Iva Miljkovic; Michael A Nalls; Dena Hernandez; Bruce M Psaty; Fernando Rivadeneira; Jerome Rotter; Sudha Seshadri; Albert V Smith; Kent D Taylor; Henning Tiemeier; Hae-Won Uh; André G Uitterlinden; James W Vaupel; Jeremy Walston; Rudi G J Westendorp; Tamara B Harris; Thomas Lumley; Cornelia M van Duijn; Joanne M Murabito
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-03-18       Impact factor: 6.053

5.  Familial excess longevity in Utah genealogies.

Authors:  R A Kerber; E O'Brien; K R Smith; R M Cawthon
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2001-03       Impact factor: 6.053

6.  "Predicting" parental longevity from offspring endophenotypes: data from the Long Life Family Study (LLFS).

Authors:  Anatoli I Yashin; Konstantin G Arbeev; Alexander Kulminski; Ingrid Borecki; Kaare Christensen; Michael Barmada; Evan Hadley; Winifred Rossi; Joseph H Lee; Rong Cheng; Irma T Elo
Journal:  Mech Ageing Dev       Date:  2010-02-23       Impact factor: 5.432

Review 7.  Methusaleh's Zoo: how nature provides us with clues for extending human health span.

Authors:  S N Austad
Journal:  J Comp Pathol       Date:  2009-12-04       Impact factor: 1.311

8.  Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population.

Authors:  Silvia Gravina; Francesco Lescai; Gregory Hurteau; Graham J Brock; Anna Saramaki; Stefano Salvioli; Claudio Franceschi; Igor B Roninson
Journal:  Aging (Albany NY)       Date:  2009-05       Impact factor: 5.682

9.  The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions.

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Journal:  Genet Epidemiol       Date:  2010-05       Impact factor: 2.135

10.  New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

Authors:  Josée Dupuis; Claudia Langenberg; Inga Prokopenko; Richa Saxena; Nicole Soranzo; Anne U Jackson; Eleanor Wheeler; Nicole L Glazer; Nabila Bouatia-Naji; Anna L Gloyn; Cecilia M Lindgren; Reedik Mägi; Andrew P Morris; Joshua Randall; Toby Johnson; Paul Elliott; Denis Rybin; Gudmar Thorleifsson; Valgerdur Steinthorsdottir; Peter Henneman; Harald Grallert; Abbas Dehghan; Jouke Jan Hottenga; Christopher S Franklin; Pau Navarro; Kijoung Song; Anuj Goel; John R B Perry; Josephine M Egan; Taina Lajunen; Niels Grarup; Thomas Sparsø; Alex Doney; Benjamin F Voight; Heather M Stringham; Man Li; Stavroula Kanoni; Peter Shrader; Christine Cavalcanti-Proença; Meena Kumari; Lu Qi; Nicholas J Timpson; Christian Gieger; Carina Zabena; Ghislain Rocheleau; Erik Ingelsson; Ping An; Jeffrey O'Connell; Jian'an Luan; Amanda Elliott; Steven A McCarroll; Felicity Payne; Rosa Maria Roccasecca; François Pattou; Praveen Sethupathy; Kristin Ardlie; Yavuz Ariyurek; Beverley Balkau; Philip Barter; John P Beilby; Yoav Ben-Shlomo; Rafn Benediktsson; Amanda J Bennett; Sven Bergmann; Murielle Bochud; Eric Boerwinkle; Amélie Bonnefond; Lori L Bonnycastle; Knut Borch-Johnsen; Yvonne Böttcher; Eric Brunner; Suzannah J Bumpstead; Guillaume Charpentier; Yii-Der Ida Chen; Peter Chines; Robert Clarke; Lachlan J M Coin; Matthew N Cooper; Marilyn Cornelis; Gabe Crawford; Laura Crisponi; Ian N M Day; Eco J C de Geus; Jerome Delplanque; Christian Dina; Michael R Erdos; Annette C Fedson; Antje Fischer-Rosinsky; Nita G Forouhi; Caroline S Fox; Rune Frants; Maria Grazia Franzosi; Pilar Galan; Mark O Goodarzi; Jürgen Graessler; Christopher J Groves; Scott Grundy; Rhian Gwilliam; Ulf Gyllensten; Samy Hadjadj; Göran Hallmans; Naomi Hammond; Xijing Han; Anna-Liisa Hartikainen; Neelam Hassanali; Caroline Hayward; Simon C Heath; Serge Hercberg; Christian Herder; Andrew A Hicks; David R Hillman; Aroon D Hingorani; Albert Hofman; Jennie Hui; Joe Hung; Bo Isomaa; Paul R V Johnson; Torben Jørgensen; Antti Jula; Marika Kaakinen; Jaakko Kaprio; Y Antero Kesaniemi; Mika Kivimaki; Beatrice Knight; Seppo Koskinen; Peter Kovacs; Kirsten Ohm Kyvik; G Mark Lathrop; Debbie A Lawlor; Olivier Le Bacquer; Cécile Lecoeur; Yun Li; Valeriya Lyssenko; Robert Mahley; Massimo Mangino; Alisa K Manning; María Teresa Martínez-Larrad; Jarred B McAteer; Laura J McCulloch; Ruth McPherson; Christa Meisinger; David Melzer; David Meyre; Braxton D Mitchell; Mario A Morken; Sutapa Mukherjee; Silvia Naitza; Narisu Narisu; Matthew J Neville; Ben A Oostra; Marco Orrù; Ruth Pakyz; Colin N A Palmer; Giuseppe Paolisso; Cristian Pattaro; Daniel Pearson; John F Peden; Nancy L Pedersen; Markus Perola; Andreas F H Pfeiffer; Irene Pichler; Ozren Polasek; Danielle Posthuma; Simon C Potter; Anneli Pouta; Michael A Province; Bruce M Psaty; Wolfgang Rathmann; Nigel W Rayner; Kenneth Rice; Samuli Ripatti; Fernando Rivadeneira; Michael Roden; Olov Rolandsson; Annelli Sandbaek; Manjinder Sandhu; Serena Sanna; Avan Aihie Sayer; Paul Scheet; Laura J Scott; Udo Seedorf; Stephen J Sharp; Beverley Shields; Gunnar Sigurethsson; Eric J G Sijbrands; Angela Silveira; Laila Simpson; Andrew Singleton; Nicholas L Smith; Ulla Sovio; Amy Swift; Holly Syddall; Ann-Christine Syvänen; Toshiko Tanaka; Barbara Thorand; Jean Tichet; Anke Tönjes; Tiinamaija Tuomi; André G Uitterlinden; Ko Willems van Dijk; Mandy van Hoek; Dhiraj Varma; Sophie Visvikis-Siest; Veronique Vitart; Nicole Vogelzangs; Gérard Waeber; Peter J Wagner; Andrew Walley; G Bragi Walters; Kim L Ward; Hugh Watkins; Michael N Weedon; Sarah H Wild; Gonneke Willemsen; Jaqueline C M Witteman; John W G Yarnell; Eleftheria Zeggini; Diana Zelenika; Björn Zethelius; Guangju Zhai; Jing Hua Zhao; M Carola Zillikens; Ingrid B Borecki; Ruth J F Loos; Pierre Meneton; Patrik K E Magnusson; David M Nathan; Gordon H Williams; Andrew T Hattersley; Kaisa Silander; Veikko Salomaa; George Davey Smith; Stefan R Bornstein; Peter Schwarz; Joachim Spranger; Fredrik Karpe; Alan R Shuldiner; Cyrus Cooper; George V Dedoussis; Manuel Serrano-Ríos; Andrew D Morris; Lars Lind; Lyle J Palmer; Frank B Hu; Paul W Franks; Shah Ebrahim; Michael Marmot; W H Linda Kao; James S Pankow; Michael J Sampson; Johanna Kuusisto; Markku Laakso; Torben Hansen; Oluf Pedersen; Peter Paul Pramstaller; H Erich Wichmann; Thomas Illig; Igor Rudan; Alan F Wright; Michael Stumvoll; Harry Campbell; James F Wilson; Richard N Bergman; Thomas A Buchanan; Francis S Collins; Karen L Mohlke; Jaakko Tuomilehto; Timo T Valle; David Altshuler; Jerome I Rotter; David S Siscovick; Brenda W J H Penninx; Dorret I Boomsma; Panos Deloukas; Timothy D Spector; Timothy M Frayling; Luigi Ferrucci; Augustine Kong; Unnur Thorsteinsdottir; Kari Stefansson; Cornelia M van Duijn; Yurii S Aulchenko; Antonio Cao; Angelo Scuteri; David Schlessinger; Manuela Uda; Aimo Ruokonen; Marjo-Riitta Jarvelin; Dawn M Waterworth; Peter Vollenweider; Leena Peltonen; Vincent Mooser; Goncalo R Abecasis; Nicholas J Wareham; Robert Sladek; Philippe Froguel; Richard M Watanabe; James B Meigs; Leif Groop; Michael Boehnke; Mark I McCarthy; Jose C Florez; Inês Barroso
Journal:  Nat Genet       Date:  2010-01-17       Impact factor: 38.330
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  11 in total

1.  Genomics of human health and aging.

Authors:  Alexander M Kulminski; Irina Culminskaya
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Review 2.  Genes against aging.

Authors:  Richard A Miller
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-03-28       Impact factor: 6.053

Review 3.  Unraveling genetic origin of aging-related traits: evolving concepts.

Authors:  Alexander M Kulminski
Journal:  Rejuvenation Res       Date:  2013-08       Impact factor: 4.663

4.  Increasing Sibling Relative Risk of Survival to Older and Older Ages and the Importance of Precise Definitions of "Aging," "Life Span," and "Longevity".

Authors:  Paola Sebastiani; Lisa Nussbaum; Stacy L Andersen; Mara J Black; Thomas T Perls
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2015-03-26       Impact factor: 6.053

5.  High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity.

Authors:  Brenda Gonzalez; Archana Tare; Seungjin Ryu; Simon C Johnson; Gil Atzmon; Nir Barzilai; Matt Kaeberlein; Yousin Suh
Journal:  Geroscience       Date:  2022-08-10       Impact factor: 7.581

6.  Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children.

Authors:  Alexander M Kulminski; Konstantin G Arbeev; Kaare Christensen; Eric Stallard; Iva Miljkovic; Michael Barmada; Anatoliy I Yashin
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-12-04       Impact factor: 6.053

7.  Whole genome sequences of a male and female supercentenarian, ages greater than 114 years.

Authors:  Paola Sebastiani; Alberto Riva; Monty Montano; Phillip Pham; Ali Torkamani; Eugene Scherba; Gary Benson; Jacqueline N Milton; Clinton T Baldwin; Stacy Andersen; Nicholas J Schork; Martin H Steinberg; Thomas T Perls
Journal:  Front Genet       Date:  2012-01-03       Impact factor: 4.599

8.  Genetic signatures of exceptional longevity in humans.

Authors:  Paola Sebastiani; Nadia Solovieff; Andrew T Dewan; Kyle M Walsh; Annibale Puca; Stephen W Hartley; Efthymia Melista; Stacy Andersen; Daniel A Dworkis; Jemma B Wilk; Richard H Myers; Martin H Steinberg; Monty Montano; Clinton T Baldwin; Josephine Hoh; Thomas T Perls
Journal:  PLoS One       Date:  2012-01-18       Impact factor: 3.240

9.  Meta‐analysis of genetic variants associated with human exceptional longevity.

Authors:  Paola Sebastiani; Harold Bae; Fangui X Sun; Stacy L Andersen; E Warwick Daw; Alberto Malovini; Toshio Kojima; Nobuyoshi Hirose; Nicole Schupf; Annibale Puca; Thomas T Perls
Journal:  Aging (Albany NY)       Date:  2013-09       Impact factor: 5.682

10.  Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart-related traits.

Authors:  Alexander M Kulminski; Yelena Kernogitski; Irina Culminskaya; Yury Loika; Konstantin G Arbeev; Olivia Bagley; Matt Duan; Liubov Arbeeva; Svetlana V Ukraintseva; Deqing Wu; Eric Stallard; Anatoliy I Yashin
Journal:  Aging Cell       Date:  2016-09-28       Impact factor: 9.304
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