Literature DB >> 22458337

Synthesis of ureidomuraymycidine derivatives for structure-activity relationship studies of muraymycins.

Bilal A Aleiwi1, Christopher M Schneider, Michio Kurosu.   

Abstract

One of the key constituents of the muraymycins is the 6-membered cyclic guanidine, (2S,3S)-muraymycidine (or epi-capreomycidine). In order to diversify the structure of the oligopeptide moiety of the muraymycins for thorough structure-activity relationship studies, we have developed a highly stereoselective synthesis of ureidomuraymycidine derivatives with the lactone 4a.
© 2012 American Chemical Society

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Year:  2012        PMID： 22458337      PMCID： PMC3374721          DOI： 10.1021/jo300205b

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  29 in total

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8.  Asymmetric synthesis of (2S,3R)-capreomycidine and the total synthesis of capreomycin IB.

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7.  Analogues of Muraymycin Nucleoside Antibiotics with Epimeric Uridine-Derived Core Structures.

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Review 8.  Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents.

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9.  Muraymycin Nucleoside Antibiotics: Structure-Activity Relationship for Variations in the Nucleoside Unit.

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  9 in total

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