Literature DB >> 22456895

Cyclic diarylheptanoids as inhibitors of NO production from Acer nikoense.

Jun Deguchi1, Yusuke Motegi, Asami Nakata, Takahiro Hosoya, Hiroshi Morita.   

Abstract

We prepared a series of acerogenins A and B derivatives as inhibitors of nitric oxide (NO) production in vitro. Our results suggested that an ester group at a hydroxyl at C-2 improved inhibitory effects without cytotoxicity. A benzoyl ester derivative of acerogenin C showed the most potent inhibitory activity of NO production from lipopolysaccharide-activated macrophages.

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Year:  2012        PMID： 22456895     DOI： 10.1007/s11418-012-0660-0

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  19 in total

1.  Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents.

Authors:  Hironori Ohtsu; Zhiyan Xiao; Junko Ishida; Masahiro Nagai; Hui-Kang Wang; Hideji Itokawa; Ching-Yuan Su; Charles Shih; Tzuying Chiang; Eugene Chang; YiFen Lee; Meng-Yin Tsai; Chawnshang Chang; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2002-11-07       Impact factor: 7.446

2.  Docosahexaenoic acid suppresses nitric oxide production and inducible nitric oxide synthase expression in interferon-gamma plus lipopolysaccharide-stimulated murine macrophages by inhibiting the oxidative stress.

Authors:  Wataru Komatsu; Kenji Ishihara; Masakazu Murata; Hiroaki Saito; Kazuki Shinohara
Journal:  Free Radic Biol Med       Date:  2003-04-15       Impact factor: 7.376

3.  The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide.

Authors:  M W Radomski; R M Palmer; S Moncada
Journal:  Br J Pharmacol       Date:  1987-11       Impact factor: 8.739

4.  Modulation of acute inflammation by endogenous nitric oxide.

Authors:  A Ialenti; A Ianaro; S Moncada; M Di Rosa
Journal:  Eur J Pharmacol       Date:  1992-02-11       Impact factor: 4.432

5.  A Unified Strategy toward the Synthesis of Acerogenin-Type Macrocycles: Total Syntheses of Acerogenins A, B, C, and L and Aceroside IV.

Authors:  Gabriela Islas Gonzalez; Jieping Zhu
Journal:  J Org Chem       Date:  1999-02-05       Impact factor: 4.354

Review 6.  iNOS-mediated nitric oxide production and its regulation.

Authors:  Fugen Aktan
Journal:  Life Sci       Date:  2004-06-25       Impact factor: 5.037

7.  Serum albumin induces iNOS expression and NO production in RAW 267.4 macrophages.

Authors:  Michael Poteser; Ichiro Wakabayashi
Journal:  Br J Pharmacol       Date:  2004-08-02       Impact factor: 8.739

8.  Chemopreventive potential of cyclic diarylheptanoids.

Authors:  Junko Ishida; Mutsuo Kozuka; Harukuni Tokuda; Hoyoku Nishino; Seiji Nagumo; Kuo Hsiung Lee; Masahiro Nagai
Journal:  Bioorg Med Chem       Date:  2002-10       Impact factor: 3.641

Review 9.  [Constituents of Acer nikoense and Myrica rubra. On diarylheptanoids].

Authors:  T Inoue
Journal:  Yakugaku Zasshi       Date:  1993-03       Impact factor: 0.302

10.  Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense.

Authors:  Hiroshi Morita; Jun Deguchi; Yusuke Motegi; Seizo Sato; Chihiro Aoyama; Jiro Takeo; Motoo Shiro; Yusuke Hirasawa
Journal:  Bioorg Med Chem Lett       Date:  2009-12-11       Impact factor: 2.823
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  5 in total

1.  Oxomollugin, a potential inhibitor of lipopolysaccharide-induced nitric oxide production including nuclear factor kappa B signals.

Authors:  Hiroshi Morita; Hitomi Nishino; Yuki Nakajima; Yoshiaki Kakubari; Asami Nakata; Jun Deguchi; Alfarius Eko Nugroho; Yusuke Hirasawa; Toshio Kaneda; Yoko Kawasaki; Yukihiro Goda
Journal:  J Nat Med       Date:  2015-07-01       Impact factor: 2.343

2.  Synthesis and antibacterial evaluation of macrocyclic diarylheptanoid derivatives.

Authors:  Hao Lin; David F Bruhn; Marcus M Maddox; Aman P Singh; Richard E Lee; Dianqing Sun
Journal:  Bioorg Med Chem Lett       Date:  2016-06-27       Impact factor: 2.823

3.  Four new Amaryllidaceae alkaloids from Zephyranthes candida.

Authors:  Nanase Shitara; Yusuke Hirasawa; Shunsuke Hasumi; Tadahiro Sasaki; Misaki Matsumoto; Chin Piow Wong; Toshio Kaneda; Yoshinori Asakawa; Hiroshi Morita
Journal:  J Nat Med       Date:  2014-02-14       Impact factor: 2.343

4.  Opaciniols A-C, new terpenoids from Garcinia opaca.

Authors:  Reika Mori; Alfarius Eko Nugroho; Yusuke Hirasawa; Chin Piow Wong; Toshio Kaneda; Osamu Shirota; A Hamid A Hadi; Hiroshi Morita
Journal:  J Nat Med       Date:  2013-03-28       Impact factor: 2.343

5.  Mumic acids A-E: new diterpenoids from mumiyo.

Authors:  Yuko Kiren; Alfarius Eko Nugroho; Yusuke Hirasawa; Osamu Shirota; Myrzaim Bekenova; Narbekov Omorbay Narbekovich; Marina Shapilova; Hiromichi Maeno; Hiroshi Morita
Journal:  J Nat Med       Date:  2013-04-23       Impact factor: 2.343
  5 in total

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