| Literature DB >> 20036535 |
Hiroshi Morita1, Jun Deguchi, Yusuke Motegi, Seizo Sato, Chihiro Aoyama, Jiro Takeo, Motoo Shiro, Yusuke Hirasawa.
Abstract
Two cyclic diarylheptanoids, acerogenins A (1) and B (2) have been isolated from the bark of Acer nikoense as inhibitors of Na(+)-glucose cotransporter (SGLT). Acerogenins A (1) and B (2) inhibited both isoforms, SGLT1 and SGLT2. Structure-activity relationship of acerogenin derivatives on inhibitory activity of SGLT as well as conformational analysis of 1 and 2 on the basis of J-resolved HMBC spectra and X-ray analysis were discussed. Copyright (c) 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 20036535 DOI： 10.1016/j.bmcl.2009.12.036
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823