Literature DB >> 22454323

Octanoic acid suppresses harmaline-induced tremor in mouse model of essential tremor.

Fatta B Nahab1, Adrian Handforth, Tyler Brown, Christopher Shin, Arnulfo Quesada, Chuanhui Dong, Dietrich Haubenberger, Mark Hallett.   

Abstract

Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET.

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Year:  2012        PMID： 22454323      PMCID： PMC3441932          DOI： 10.1007/s13311-012-0121-1

Source DB:  PubMed          Journal:  Neurotherapeutics        ISSN： 1878-7479            Impact factor:   7.620


  15 in total

1.  Defective dentate nucleus GABA receptors in essential tremor.

Authors:  Sarah Paris-Robidas; Elodie Brochu; Marion Sintes; Vincent Emond; Mélanie Bousquet; Milène Vandal; Mireille Pilote; Cyntia Tremblay; Thérèse Di Paolo; Ali H Rajput; Alex Rajput; Frédéric Calon
Journal:  Brain       Date:  2011-11-26       Impact factor: 13.501

2.  The relationship of essential tremor to other movement disorders: report on 678 patients. Essential Tremor Study Group.

Authors:  W C Koller; K Busenbark; K Miner
Journal:  Ann Neurol       Date:  1994-06       Impact factor: 10.422

3.  Properties and distribution of ionic conductances generating electroresponsiveness of mammalian inferior olivary neurones in vitro.

Authors:  R Llinás; Y Yarom
Journal:  J Physiol       Date:  1981-06       Impact factor: 5.182

Review 4.  Treatment of patients with essential tremor.

Authors:  Günther Deuschl; Jan Raethjen; Helge Hellriegel; Rodger Elble
Journal:  Lancet Neurol       Date:  2011-02       Impact factor: 44.182

5.  Harmaline-induced tremor as a potential preclinical screening method for essential tremor medications.

Authors:  Fredricka C Martin; Anh Thu Le; Adrian Handforth
Journal:  Mov Disord       Date:  2005-03       Impact factor: 10.338

6.  GABAergic dysfunction in essential tremor: an 11C-flumazenil PET study.

Authors:  Henning Boecker; Adolf Weindl; David J Brooks; Andres O Ceballos-Baumann; Christoph Liedtke; Matthias Miederer; Till Sprenger; Klaus J Wagner; Isabelle Miederer
Journal:  J Nucl Med       Date:  2010-06-16       Impact factor: 10.057

7.  The effectiveness of different isomers of octanol as blockers of harmaline-induced tremor.

Authors:  C M Sinton; B I Krosser; K D Walton; R R Llinás
Journal:  Pflugers Arch       Date:  1989-05       Impact factor: 3.657

8.  Effect of alcohol on tremors: comparison with propranolol.

Authors:  W C Koller; N Biary
Journal:  Neurology       Date:  1984-02       Impact factor: 9.910

9.  Positive allosteric modulators of the GABA(A) receptor: differential interaction of benzodiazepines and neuroactive steroids with ethanol.

Authors:  K E Vanover; M Suruki; S Robledo; M Huber; S Wieland; N C Lan; K W Gee; P L Wood; R B Carter
Journal:  Psychopharmacology (Berl)       Date:  1999-01       Impact factor: 4.530

10.  Pilot trial of 1-octanol in essential tremor.

Authors:  K O Bushara; S R Goldstein; G J Grimes; A H Burstein; M Hallett
Journal:  Neurology       Date:  2004-01-13       Impact factor: 9.910
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  6 in total

Review 1.  Review on clinical update of essential tremor.

Authors:  Wei Chunling; Xiao Zheng
Journal:  Neurol Sci       Date:  2016-01-09       Impact factor: 3.307

2.  Octanoic acid in alcohol-responsive essential tremor: a randomized controlled study.

Authors:  Dietrich Haubenberger; Gayle McCrossin; Codrin Lungu; Elaine Considine; Camilo Toro; Fatta B Nahab; Sungyoung Auh; Peter Buchwald; George J Grimes; Judith Starling; Gopal Potti; Linda Scheider; Daniel Kalowitz; Daniel Bowen; Andrea Carnie; Mark Hallett
Journal:  Neurology       Date:  2013-02-13       Impact factor: 9.910

3.  Genome Estimation and Phytochemical Compound Identification in the Leaves and Callus of Abrus precatorius: A Locally Endangered Plant from the Flora of Saudi Arabia.

Authors:  Fahad Al-Qurainy; Mohamed Tarroum; Salim Khan; Mohammad Nadeem; Abdel-Rhman Z Gaafar; Saleh Alansi; Norah S Alfarraj
Journal:  Plants (Basel)       Date:  2022-02-21

4.  Treatment of essential tremor with long-chain alcohols: still experimental or ready for prime time?

Authors:  Dietrich Haubenberger; Fatta B Nahab; Bernhard Voller; Mark Hallett
Journal:  Tremor Other Hyperkinet Mov (N Y)       Date:  2014-02-05

Review 5.  Current and Future Neuropharmacological Options for the Treatment of Essential Tremor.

Authors:  Hortensia Alonso-Navarro; Elena García-Martín; José A G Agúndez; Félix J Jiménez-Jiménez
Journal:  Curr Neuropharmacol       Date:  2020       Impact factor: 7.363

Review 6.  Managing Essential Tremor.

Authors:  Franziska Hopfner; Günther Deuschl
Journal:  Neurotherapeutics       Date:  2020-10       Impact factor: 6.088
  6 in total

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