Literature DB >> 22453214

Androgen action and metabolism in prostate cancer.

Sean M Green1, Elahe A Mostaghel, Peter S Nelson.   

Abstract

The transcriptional programs regulated through the activity of the androgen receptor (AR) modulate normal prostate development and the maintenance of prostatic functions at maturity. AR signaling also controls key survival and growth functions operative in prostate cancer. Inhibiting the AR program remains the key target in the treatment of advanced prostate cancer, and suppressing AR also holds great potential for preventing the development or progression of early stage prostate cancer. In this review, we detail molecular mechanisms of AR activity, cellular components contributing to the maintenance of AR signaling despite AR-ligand suppression, and discuss treatment strategies designed to target components of resistance to AR-directed therapeutics.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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Year:  2012        PMID： 22453214      PMCID： PMC4124858          DOI： 10.1016/j.mce.2011.09.046

Source DB:  PubMed          Journal:  Mol Cell Endocrinol        ISSN： 0303-7207            Impact factor:   4.102


  125 in total

1.  Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium.

Authors:  M Stanbrough; I Leav; P W Kwan; G J Bubley; S P Balk
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-04       Impact factor: 11.205

2.  Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways.

Authors:  M D Sadar
Journal:  J Biol Chem       Date:  1999-03-19       Impact factor: 5.157

3.  Amplification of the androgen receptor gene in bone metastases from hormone-refractory prostate cancer.

Authors:  R S D Brown; J Edwards; A Dogan; H Payne; S J Harland; J M S Bartlett; J R W Masters
Journal:  J Pathol       Date:  2002-10       Impact factor: 7.996

Review 4.  Ras signaling in prostate cancer progression.

Authors:  Michael J Weber; Daniel Gioeli
Journal:  J Cell Biochem       Date:  2004-01-01       Impact factor: 4.429

5.  Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT).

Authors:  Jennifer A Locke; Kishor M Wasan; Colleen C Nelson; Emma S Guns; Carlos G Leon
Journal:  Prostate       Date:  2008-01-01       Impact factor: 4.104

6.  Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.

Authors:  Qianben Wang; Wei Li; Yong Zhang; Xin Yuan; Kexin Xu; Jindan Yu; Zhong Chen; Rameen Beroukhim; Hongyun Wang; Mathieu Lupien; Tao Wu; Meredith M Regan; Clifford A Meyer; Jason S Carroll; Arjun Kumar Manrai; Olli A Jänne; Steven P Balk; Rohit Mehra; Bo Han; Arul M Chinnaiyan; Mark A Rubin; Lawrence True; Michelangelo Fiorentino; Christopher Fiore; Massimo Loda; Philip W Kantoff; X Shirley Liu; Myles Brown
Journal:  Cell       Date:  2009-07-23       Impact factor: 41.582

7.  Molecular determinants of resistance to antiandrogen therapy.

Authors:  Charlie D Chen; Derek S Welsbie; Chris Tran; Sung Hee Baek; Randy Chen; Robert Vessella; Michael G Rosenfeld; Charles L Sawyers
Journal:  Nat Med       Date:  2003-12-21       Impact factor: 53.440

8.  Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone.

Authors:  Z Culig; A Hobisch; M V Cronauer; A C Cato; A Hittmair; C Radmayr; J Eberle; G Bartsch; H Klocker
Journal:  Mol Endocrinol       Date:  1993-12

9.  Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castration-resistant prostate cancer.

Authors:  Changmeng Cai; Hongyun Wang; Youyuan Xu; Shaoyong Chen; Steven P Balk
Journal:  Cancer Res       Date:  2009-07-07       Impact factor: 12.701

10.  Androgen receptor gene amplification and protein expression in recurrent prostate cancer.

Authors:  O Harris Ford; Christopher W Gregory; Desok Kim; Andrew B Smitherman; James L Mohler
Journal:  J Urol       Date:  2003-11       Impact factor: 7.450
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  63 in total

1.  Bypassing Drug Resistance Mechanisms of Prostate Cancer with Small Molecules that Target Androgen Receptor-Chromatin Interactions.

Authors:  Kush Dalal; Meixia Che; Nanette S Que; Aishwariya Sharma; Rendong Yang; Nada Lallous; Hendrik Borgmann; Deniz Ozistanbullu; Ronnie Tse; Fuqiang Ban; Huifang Li; Kevin J Tam; Mani Roshan-Moniri; Eric LeBlanc; Martin E Gleave; Daniel T Gewirth; Scott M Dehm; Artem Cherkasov; Paul S Rennie
Journal:  Mol Cancer Ther       Date:  2017-08-03       Impact factor: 6.261

2.  Properties of Native High-Density Lipoproteins Inspire Synthesis of Actively Targeted In Vivo siRNA Delivery Vehicles.

Authors:  Kaylin M McMahon; Michael P Plebanek; C Shad Thaxton
Journal:  Adv Funct Mater       Date:  2016-09-20       Impact factor: 18.808

3.  Androgen-regulated microRNA-135a decreases prostate cancer cell migration and invasion through downregulating ROCK1 and ROCK2.

Authors:  A Kroiss; S Vincent; M Decaussin-Petrucci; E Meugnier; J Viallet; A Ruffion; F Chalmel; J Samarut; N Allioli
Journal:  Oncogene       Date:  2014-07-28       Impact factor: 9.867

4.  Nuclear mobility and activity of FOXA1 with androgen receptor are regulated by SUMOylation.

Authors:  Päivi Sutinen; Vesa Rahkama; Miia Rytinki; Jorma J Palvimo
Journal:  Mol Endocrinol       Date:  2014-08-15

5.  Dehydroepiandrosterone-induces miR-21 transcription in HepG2 cells through estrogen receptor β and androgen receptor.

Authors:  Yun Teng; Lacey M Litchfield; Margarita M Ivanova; Russell A Prough; Barbara J Clark; Carolyn M Klinge
Journal:  Mol Cell Endocrinol       Date:  2014-05-17       Impact factor: 4.102

6.  ZBTB7A Mediates the Transcriptional Repression Activity of the Androgen Receptor in Prostate Cancer.

Authors:  Dong Han; Sujun Chen; Wanting Han; Shuai Gao; Jude N Owiredu; Muqing Li; Steven P Balk; Housheng Hansen He; Changmeng Cai
Journal:  Cancer Res       Date:  2019-08-23       Impact factor: 12.701

7.  Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity.

Authors:  Changmeng Cai; Housheng Hansen He; Shuai Gao; Sen Chen; Ziyang Yu; Yanfei Gao; Shaoyong Chen; Mei Wei Chen; Jesse Zhang; Musaddeque Ahmed; Yang Wang; Eric Metzger; Roland Schüle; X Shirley Liu; Myles Brown; Steven P Balk
Journal:  Cell Rep       Date:  2014-12-04       Impact factor: 9.423

8.  Testosterone accumulation in prostate cancer cells is enhanced by facilitated diffusion.

Authors:  Arja Kaipainen; Ailin Zhang; Rui M Gil da Costa; Jared Lucas; Brett Marck; Alvin M Matsumoto; Colm Morrissey; Lawrence D True; Elahe A Mostaghel; Peter S Nelson
Journal:  Prostate       Date:  2019-08-02       Impact factor: 4.104

Review 9.  The Tumor Macroenvironment: Cancer-Promoting Networks Beyond Tumor Beds.

Authors:  Melanie R Rutkowski; Nikolaos Svoronos; Alfredo Perales-Puchalt; Jose R Conejo-Garcia
Journal:  Adv Cancer Res       Date:  2015-05-21       Impact factor: 6.242

10.  Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer.

Authors:  Kush Dalal; Mani Roshan-Moniri; Aishwariya Sharma; Huifang Li; Fuqiang Ban; Mohamed Hessein; Michael Hsing; Kriti Singh; Eric LeBlanc; Scott Dehm; Emma S Tomlinson Guns; Artem Cherkasov; Paul S Rennie
Journal:  J Biol Chem       Date:  2014-08-01       Impact factor: 5.157
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