Literature DB >> 22450131

A new pancreatic lipase inhibitor from Broussonetia kanzinoki.

Jong Hoon Ahn1, Qing Liu, Chul Lee, Mi-Jeong Ahn, Hwan-Soo Yoo, Bang Yeon Hwang, Mi Kyeong Lee.   

Abstract

A new phenolic compound, broussonone A (1) were isolated from the stem barks of Broussonetia kanzinoki (Moraceae), together with two diphenylpropanes, broussonin A (2), broussonin B (3), two flavans, 7,4'-dihydroxyflavan (4), 3',7-dihydroxy-4'-methoxyflavan (5), and two flavones, 3,7-dihydroxy-4'-methoxyflavone (6), 3,7,3'-trihydroxy-4'-methoxyflavone (7). Compound 1 showed noncompetitive inhibitory activity on pancreatic lipase with an IC(50) of 28.4 μM. In addition, compounds 1-5 significantly inhibited adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22450131     DOI： 10.1016/j.bmcl.2012.02.088

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

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Authors:  Kun Wei; Gang-Qiang Wang; Xue Bai; Yan-Fen Niu; He-Ping Chen; Chun-Nan Wen; Zheng-Hui Li; Ze-Jun Dong; Zhi-Li Zuo; Wen-Yong Xiong; Ji-Kai Liu
Journal:  Nat Prod Bioprospect       Date:  2015-06-18

2.  Effect of germinated brown rice extracts on pancreatic lipase, adipogenesis and lipolysis in 3T3-L1 adipocytes.

Authors:  See Meng Lim; Yong Meng Goh; Wen Bin Kuan; Su Peng Loh
Journal:  Lipids Health Dis       Date:  2014-11-03       Impact factor: 3.876

3.  A Bioactivity-Based Method for Screening, Identification of Lipase Inhibitors, and Clarifying the Effects of Processing Time on Lipase Inhibitory Activity of Polygonum Multiflorum.

Authors:  Yan-Xu Chang; Ai-Hua Ge; Yan Jiang; John Teye Azietaku; Jin Li; Xiu-Mei Gao
Journal:  Evid Based Complement Alternat Med       Date:  2016-01-26       Impact factor: 2.629

4.  Broussonin A- and B-mediated inhibition of angiogenesis by blockade of VEGFR-2 signalling pathways and integrin β1 expression.

Authors:  Jae Hyeon Kim; Sunho Kim; Surim Han; Eun-Kyung Ahn; Young-Rak Cho; Wonsik Jeong; Sung Joon Kim; Gyu-Un Bae; Joa Sub Oh; Dong-Wan Seo
Journal:  J Cell Mol Med       Date:  2022-01-06       Impact factor: 5.310

Review 5.  The Genus Broussonetia: An Updated Review of Phytochemistry, Pharmacology and Applications.

Authors:  Yueru Chen; Lu Wang; Xue Liu; Fulin Wang; Ying An; Wei Zhao; Jinli Tian; Degang Kong; Wenru Zhang; Yang Xu; Yahui Ba; Honglei Zhou
Journal:  Molecules       Date:  2022-08-22       Impact factor: 4.927

6.  Comparison of Metabolites Variation and Antiobesity Effects of Fermented versus Nonfermented Mixtures of Cudrania tricuspidata, Lonicera caerulea, and Soybean According to Fermentation In Vitro and In Vivo.

Authors:  Dong Ho Suh; Eun Sung Jung; Hye Min Park; Seung Hyung Kim; Sarah Lee; Yang Hee Jo; Mi Kyeong Lee; Gayoung Jung; Seon-Gil Do; Choong Hwan Lee
Journal:  PLoS One       Date:  2016-02-05       Impact factor: 3.240

7.  Study of Antiobesity Effect through Inhibition of Pancreatic Lipase Activity of Diospyros kaki Fruit and Citrus unshiu Peel.

Authors:  Gyo-Nam Kim; Mi-Rae Shin; Sung Ho Shin; Ah Reum Lee; Joo Young Lee; Bu-Il Seo; Min Yeong Kim; Tae Hoon Kim; Jeong Sook Noh; Man Hee Rhee; Seong-Soo Roh
Journal:  Biomed Res Int       Date:  2016-07-27       Impact factor: 3.411

8.  Concise Synthesis of Broussonone A.

Authors:  Hyeju Jo; Minho Choi; Mayavan Viji; Young Hee Lee; Young-Shin Kwak; Kiho Lee; Nam Song Choi; Yeon-Ju Lee; Heesoon Lee; Jin Tae Hong; Mi Kyeong Lee; Jae-Kyung Jung
Journal:  Molecules       Date:  2015-09-02       Impact factor: 4.411

9.  Antioxidant evaluation-guided chemical profiling and structure-activity analysis of leaf extracts from five trees in Broussonetia and Morus (Moraceae).

Authors:  Xinxin Cao; Lingguang Yang; Qiang Xue; Fan Yao; Jing Sun; Fuyu Yang; Yujun Liu
Journal:  Sci Rep       Date:  2020-03-16       Impact factor: 4.379
  9 in total

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