Literature DB >> 22449928

Imaging the efficacy of anti-inflammatory liposomes in a rabbit model of atherosclerosis by non-invasive imaging.

Mark E Lobatto1, Claudia Calcagno, Josbert M Metselaar, Gert Storm, Erik S G Stroes, Zahi A Fayad, Willem J M Mulder.   

Abstract

Nanomedicine can provide a potent alternative to current therapeutic strategies for atherosclerosis. For example, the encapsulation of anti-inflammatory drugs into liposomes improves their pharmacokinetics and biodistribution, thereby enhancing bioavailability to atherosclerotic plaques and improving therapeutic efficacy. The evaluation of this type of experimental therapeutics can greatly benefit from in vivo evaluation to assess biological changes, which can be performed by non-invasive imaging techniques, such as ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Here, we will illustrate the methods for inducing atherosclerosis in a rabbit model, the production of anti-inflammatory liposomes and monitoring of therapeutic efficacy of experimental therapeutics with the above-mentioned imaging techniques.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22449928      PMCID： PMC3612346          DOI： 10.1016/B978-0-12-391860-4.00011-2

Source DB:  PubMed          Journal:  Methods Enzymol        ISSN： 0076-6879            Impact factor:   1.600


  35 in total

1.  Quantitative pharmacokinetic analysis of DCE-MRI data without an arterial input function: a reference region model.

Authors:  Thomas E Yankeelov; Jeffrey J Luci; Martin Lepage; Rui Li; Laura Debusk; P Charles Lin; Ronald R Price; John C Gore
Journal:  Magn Reson Imaging       Date:  2005-05       Impact factor: 2.546

2.  Comparative study into the robustness of compartmental modeling and model-free analysis in DCE-MRI studies.

Authors:  Caleb Roberts; Basma Issa; Andrew Stone; Alan Jackson; John C Waterton; Geoffrey J M Parker
Journal:  J Magn Reson Imaging       Date:  2006-04       Impact factor: 4.813

3.  Carotid artery atherosclerosis: effect of intensive lipid therapy on the vasa vasorum--evaluation by using dynamic contrast-enhanced MR imaging.

Authors:  Li Dong; Williams S Kerwin; Huijun Chen; Baocheng Chu; Hunter R Underhill; Moni Blazej Neradilek; Thomas S Hatsukami; Chun Yuan; Xue-Qiao Zhao
Journal:  Radiology       Date:  2011-04-14       Impact factor: 11.105

Review 4.  Dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) of atherosclerotic plaque angiogenesis.

Authors:  Claudia Calcagno; Venkatesh Mani; Sarayu Ramachandran; Zahi A Fayad
Journal:  Angiogenesis       Date:  2010-06-06       Impact factor: 9.596

Review 5.  Developments in liposomal drug delivery systems.

Authors:  N Maurer; D B Fenske; P R Cullis
Journal:  Expert Opin Biol Ther       Date:  2001-11       Impact factor: 4.388

6.  Inflammation in carotid atherosclerotic plaque: a dynamic contrast-enhanced MR imaging study.

Authors:  William S Kerwin; Kevin D O'Brien; Marina S Ferguson; Nayak Polissar; Thomas S Hatsukami; Chun Yuan
Journal:  Radiology       Date:  2006-09-11       Impact factor: 11.105

7.  Hypercholesterolemia enhances macrophage recruitment and dysfunction of regenerated endothelium after balloon injury of the rabbit iliac artery.

Authors:  F F Weidinger; J M McLenachan; M I Cybulsky; J T Fallon; N K Hollenberg; J P Cooke; P Ganz
Journal:  Circulation       Date:  1991-08       Impact factor: 29.690

8.  (18)Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: implications for atherosclerosis therapy trials.

Authors:  James H F Rudd; Kelly S Myers; Sameer Bansilal; Josef Machac; Ash Rafique; Michael Farkouh; Valentin Fuster; Zahi A Fayad
Journal:  J Am Coll Cardiol       Date:  2007-08-13       Impact factor: 24.094

Review 9.  Dynamic contrast-enhanced MRI in clinical oncology: current status and future directions.

Authors:  Anwar R Padhani
Journal:  J Magn Reson Imaging       Date:  2002-10       Impact factor: 4.813

Review 10.  Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols.

Authors:  P S Tofts; G Brix; D L Buckley; J L Evelhoch; E Henderson; M V Knopp; H B Larsson; T Y Lee; N A Mayr; G J Parker; R E Port; J Taylor; R M Weisskoff
Journal:  J Magn Reson Imaging       Date:  1999-09       Impact factor: 4.813
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  18 in total

1.  Registration of dynamic contrast-enhanced MRI of the common carotid artery using a fixed-frame template-based squared-difference method.

Authors:  Sarayu Ramachandran; Claudia Calcagno; Venkatesh Mani; Philip M Robson; Zahi A Fayad
Journal:  J Magn Reson Imaging       Date:  2013-10-07       Impact factor: 4.813

2.  Atherosclerotic plaque inflammation quantification using dynamic contrast-enhanced (DCE) MRI.

Authors:  Huijun Chen; Tingting Wu; William S Kerwin; Chun Yuan
Journal:  Quant Imaging Med Surg       Date:  2013-12

3.  Attenuation correction for flexible magnetic resonance coils in combined magnetic resonance/positron emission tomography imaging.

Authors:  Mootaz Eldib; Jason Bini; Claudia Calcagno; Philip M Robson; Venkatesh Mani; Zahi A Fayad
Journal:  Invest Radiol       Date:  2014-02       Impact factor: 6.016

4.  Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis.

Authors:  Yongtae Kim; Mark E Lobatto; Tomohiro Kawahara; Bomy Lee Chung; Aneta J Mieszawska; Brenda L Sanchez-Gaytan; Francois Fay; Max L Senders; Claudia Calcagno; Jacob Becraft; May Tun Saung; Ronald E Gordon; Erik S G Stroes; Mingming Ma; Omid C Farokhzad; Zahi A Fayad; Willem J M Mulder; Robert Langer
Journal:  Proc Natl Acad Sci U S A       Date:  2014-01-06       Impact factor: 11.205

5.  Multimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel Wall.

Authors:  Mark E Lobatto; Tina Binderup; Philip M Robson; Luuk F P Giesen; Claudia Calcagno; Julia Witjes; Francois Fay; Samantha Baxter; Chang Ho Wessel; Mootaz Eldib; Jason Bini; Sean D Carlin; Erik S G Stroes; Gert Storm; Andreas Kjaer; Jason S Lewis; Thomas Reiner; Zahi A Fayad; Willem J M Mulder; Carlos Pérez-Medina
Journal:  Bioconjug Chem       Date:  2019-06-07       Impact factor: 4.774

6.  Monitoring plaque inflammation in atherosclerotic rabbits with an iron oxide (P904) and (18)F-FDG using a combined PET/MR scanner.

Authors:  A Millon; S D Dickson; A Klink; D Izquierdo-Garcia; J Bini; E Lancelot; S Ballet; P Robert; J Mateo de Castro; C Corot; Z A Fayad
Journal:  Atherosclerosis       Date:  2013-03-26       Impact factor: 5.162

7.  Gadolinium-Based Contrast Agents for Vessel Wall Magnetic Resonance Imaging (MRI) of Atherosclerosis.

Authors:  Claudia Calcagno; Sarayu Ramachandran; Antoine Millon; Philip M Robson; Venkatesh Mani; Zahi Fayad
Journal:  Curr Cardiovasc Imaging Rep       Date:  2012-10-14

8.  Three-dimensional dynamic contrast-enhanced MRI for the accurate, extensive quantification of microvascular permeability in atherosclerotic plaques.

Authors:  Claudia Calcagno; Mark E Lobatto; Hadrien Dyvorne; Philip M Robson; Antoine Millon; Max L Senders; Olivier Lairez; Sarayu Ramachandran; Bram F Coolen; Alexandra Black; Willem J M Mulder; Zahi A Fayad
Journal:  NMR Biomed       Date:  2015-08-30       Impact factor: 4.044

Review 9.  Monocytes and macrophages as nanomedicinal targets for improved diagnosis and treatment of disease.

Authors:  Marnix A Lameijer; Jun Tang; Matthias Nahrendorf; Robert H J Beelen; Willem J M Mulder
Journal:  Expert Rev Mol Diagn       Date:  2013-07       Impact factor: 5.225

Review 10.  Imaging and nanomedicine in inflammatory atherosclerosis.

Authors:  Willem J M Mulder; Farouc A Jaffer; Zahi A Fayad; Matthias Nahrendorf
Journal:  Sci Transl Med       Date:  2014-06-04       Impact factor: 17.956
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