Literature DB >> 2244890

Cloning and sequencing of human LH/hCG receptor cDNA.

T Minegishi1, K Nakamura, Y Takakura, K Miyamoto, Y Hasegawa, Y Ibuki, M Igarashi, T ] Minegish T [corrected to Minegishi.   

Abstract

We have isolated and sequenced a cDNA encoding the human luteinizing hormone--choriogonadotropin (LH/hCG) receptor. The deduced amino acid sequence (699 residues) containing seven putative transmembrane segments displays sequence similarity to G protein-coupled receptors. The receptor consists of 335 residue extracellular domain which contains six N-linked glycosylation sites. While the protein is 85 and 87% identical overall with the previously cloned rat and porcine LH/hCG receptor respectively, the most highly conserved regions are the putative transmembrane segments (91 and 94% similarity, respectively).

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Year:  1990        PMID： 2244890     DOI： 10.1016/0006-291x(90)91552-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  23 in total

Review 1.  Naturally occurring mutations of the luteinizing-hormone receptor: lessons learned about reproductive physiology and G protein-coupled receptors.

Authors:  A C Latronico; D L Segaloff
Journal:  Am J Hum Genet       Date:  1999-10       Impact factor: 11.025

Review 2.  Gonadotropin receptors: role of post-translational modifications and post-transcriptional regulation.

Authors:  K M J Menon; Christine L Clouser; Anil K Nair
Journal:  Endocrine       Date:  2005-04       Impact factor: 3.633

3.  A new point mutation in the luteinising hormone receptor gene in familial and sporadic male limited precocious puberty: genotype does not always correlate with phenotype.

Authors:  B A Evans; D J Bowen; P J Smith; P E Clayton; J W Gregory
Journal:  J Med Genet       Date:  1996-02       Impact factor: 6.318

Review 4.  Structure, function and regulation of gonadotropin receptors - a perspective.

Authors:  K M J Menon; Bindu Menon
Journal:  Mol Cell Endocrinol       Date:  2012-02-09       Impact factor: 4.102

5.  The Cell Type-Specific Expression of Lhcgr in Mouse Ovarian Cells: Evidence for a DNA-Demethylation-Dependent Mechanism.

Authors:  Tomoko Kawai; JoAnne S Richards; Masayuki Shimada
Journal:  Endocrinology       Date:  2018-05-01       Impact factor: 4.736

6.  Identification of constitutively activating mutation of the luteinising hormone receptor in a family with male limited gonadotrophin independent precocious puberty (testotoxicosis).

Authors:  N Kawate; G B Kletter; B E Wilson; M L Netzloff; K M Menon
Journal:  J Med Genet       Date:  1995-07       Impact factor: 6.318

Review 7.  Regulation of human luteinizing hormone receptor in the ovary.

Authors:  Takashi Minegishi; Kazuto Nakamura; Soichi Yamashita; Sadatomo Ikeda; Kayoko Kogure
Journal:  Reprod Med Biol       Date:  2008-02-01

8.  Steady-state concentrations of mRNA encoding the receptor for luteinizing hormone during the estrous cycle and following prostaglandin F(2α) treatment of ewes.

Authors:  M K Guy; J L Juengel; T R Tandeski; G D Niswender
Journal:  Endocrine       Date:  1995-08       Impact factor: 3.633

9.  A G protein-coupled receptor with low density lipoprotein-binding motifs suggests a role for lipoproteins in G-linked signal transduction.

Authors:  C P Tensen; E R Van Kesteren; R J Planta; K J Cox; J F Burke; H van Heerikhuizen; E Vreugdenhil
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

10.  Significance of the carbohydrate moiety of the rat ovarian luteinizing-hormone/chorionic-gonadotropin receptor for ligand-binding specificity and signal transduction.

Authors:  U E Petäjä-Repo; W E Merz; H J Rajaniemi
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857
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