Literature DB >> 10486313

Naturally occurring mutations of the luteinizing-hormone receptor: lessons learned about reproductive physiology and G protein-coupled receptors.

A C Latronico1, D L Segaloff.   

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Year:  1999        PMID: 10486313      PMCID: PMC1288265          DOI: 10.1086/302602

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN: 0002-9297            Impact factor:   11.025


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  58 in total

1.  An anionic residue at position 564 is important for maintaining the inactive conformation of the human lutropin/choriogonadotropin receptor.

Authors:  S Kosugi; T Mori; A Shenker
Journal:  Mol Pharmacol       Date:  1998-05       Impact factor: 4.436

2.  A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty.

Authors:  A Shenker; L Laue; S Kosugi; J J Merendino; T Minegishi; G B Cutler
Journal:  Nature       Date:  1993-10-14       Impact factor: 49.962

Review 3.  G protein-coupled receptors. II. Mechanism of agonist activation.

Authors:  U Gether; B K Kobilka
Journal:  J Biol Chem       Date:  1998-07-17       Impact factor: 5.157

4.  A mutation in the first transmembrane domain of the lutropin receptor causes male precocious puberty.

Authors:  J Gromoll; C J Partsch; M Simoni; V Nordhoff; W G Sippell; E Nieschlag; B B Saxena
Journal:  J Clin Endocrinol Metab       Date:  1998-02       Impact factor: 5.958

5.  Elevated luteinizing hormone in prepubertal transgenic mice causes hyperandrogenemia, precocious puberty, and substantial ovarian pathology.

Authors:  K A Risma; A N Hirshfield; J H Nilson
Journal:  Endocrinology       Date:  1997-08       Impact factor: 4.736

6.  A homozygous microdeletion in helix 7 of the luteinizing hormone receptor associated with familial testicular and ovarian resistance is due to both decreased cell surface expression and impaired effector activation by the cell surface receptor.

Authors:  A C Latronico; Y Chai; I J Arnhold; X Liu; B B Mendonca; D L Segaloff
Journal:  Mol Endocrinol       Date:  1998-03

7.  A homozygous mutation in the luteinizing hormone receptor causes partial Leydig cell hypoplasia: correlation between receptor activity and phenotype.

Authors:  J W Martens; M Verhoef-Post; N Abelin; M Ezabella; S P Toledo; H G Brunner; A P Themmen
Journal:  Mol Endocrinol       Date:  1998-06

8.  A novel mutation of the human luteinizing hormone receptor in 46XY and 46XX sisters.

Authors:  S S Stavrou; Y S Zhu; L Q Cai; M D Katz; C Herrera; M Defillo-Ricart; J Imperato-McGinley
Journal:  J Clin Endocrinol Metab       Date:  1998-06       Impact factor: 5.958

9.  Dual signaling potential is common among Gs-coupled receptors and dependent on receptor density.

Authors:  X Zhu; S Gilbert; M Birnbaumer; L Birnbaumer
Journal:  Mol Pharmacol       Date:  1994-09       Impact factor: 4.436

10.  A unique constitutively activating mutation in third transmembrane helix of luteinizing hormone receptor causes sporadic male gonadotropin-independent precocious puberty.

Authors:  A C Latronico; A N Abell; I J Arnhold; X Liu; T S Lins; V N Brito; A E Billerbeck; D L Segaloff; B B Mendonca
Journal:  J Clin Endocrinol Metab       Date:  1998-07       Impact factor: 5.958

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  18 in total

1.  Revisiting and questioning functional rescue between dimerized LH receptor mutants.

Authors:  Meilin Zhang; Rongbin Guan; Deborah L Segaloff
Journal:  Mol Endocrinol       Date:  2012-03-08

Review 2.  Gonadotropin receptors: role of post-translational modifications and post-transcriptional regulation.

Authors:  K M J Menon; Christine L Clouser; Anil K Nair
Journal:  Endocrine       Date:  2005-04       Impact factor: 3.633

Review 3.  The role of chorionic gonadotropin and Notch1 in implantation.

Authors:  Yalda Afshar; Adina Stanculescu; Lucio Miele; Asgerally T Fazleabas
Journal:  J Assist Reprod Genet       Date:  2007-07       Impact factor: 3.412

4.  Bioluminescence resonance energy transfer studies reveal constitutive dimerization of the human lutropin receptor and a lack of correlation between receptor activation and the propensity for dimerization.

Authors:  Rongbin Guan; Xiuyan Feng; Xueqing Wu; Meilin Zhang; Xuesen Zhang; Terence E Hébert; Deborah L Segaloff
Journal:  J Biol Chem       Date:  2009-01-15       Impact factor: 5.157

Review 5.  Constitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics.

Authors:  Ya-Xiong Tao
Journal:  Pharmacol Ther       Date:  2008-08-09       Impact factor: 12.310

6.  Activation of the lutropin/choriogonadotropin receptor in MA-10 cells leads to the tyrosine phosphorylation of the focal adhesion kinase by a pathway that involves Src family kinases.

Authors:  Tetsuya Mizutani; Koji Shiraishi; Toni Welsh; Mario Ascoli
Journal:  Mol Endocrinol       Date:  2005-11-17

7.  LH receptor gene expression in cumulus cells in women entering an ART program.

Authors:  Myrto Papamentzelopoulou; Despina Mavrogianni; George A Partsinevelos; Spyros Marinopoulos; Vasiliki Dinopoulou; Charalampos Theofanakis; Elli Anagnostou; Dimitris Loutradis
Journal:  J Assist Reprod Genet       Date:  2012-03-01       Impact factor: 3.412

8.  The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

Review 9.  Structure, function and regulation of gonadotropin receptors - a perspective.

Authors:  K M J Menon; Bindu Menon
Journal:  Mol Cell Endocrinol       Date:  2012-02-09       Impact factor: 4.102

10.  A cell surface inactive mutant of the human lutropin receptor (hLHR) attenuates signaling of wild-type or constitutively active receptors via heterodimerization.

Authors:  Meilin Zhang; Xiuyan Feng; Rongbin Guan; Terence E Hébert; Deborah L Segaloff
Journal:  Cell Signal       Date:  2009-07-16       Impact factor: 4.315

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