BACKGROUND: Plasma insulin and HOMA (homeostasis model assessment) index, used to determine insulin resistance, do not have local standard values for children and adolescents in Chile. AIM: To establish the normal reference intervals for insulin and HOMA in children and adolescents aged 10-15 years, according to sex and puberal maturation. MATERIAL AND METHODS: A cross-sectional study of 2,153 children and adolescents from Puente Alto County was performed, during 2009 and 2010. Anthropometry and self-report of puberal maturation were assessed. Fasting glucose (hexoquinase) and insulin blood levels (chemiluminiscence), were determined and HOMA index was calculated. Percentile distributions of these variables were calculated. RESULTS: The reference group included only subjects with normal body mass index and fasting blood glucose (n = 1,192). Girls had higher insulin and HOMA values than boys (12.5 ± 6.0 and 9.1 ± 4.9 μϋ/mL (p < 0.01) and 2.7 ± 1.4 and 2.1 ± 1,1 (p < 0.01), respectively). Subjects with Tanner I and II pubertal stages had lower insulin and HOMA mean values than subjects with Tanner III and IV (9.0 ± 4.3 and 12.5 ± 6.2μϋ/ml (p < 0.01) and2.0 ± 1 and2.8 ± 1.4 (p < 0.01), respectively). CONCLUSIONS: The 90th percentile of insulin and HOMA distributions according to sex and maturation, was selected as the upper cut-off point to identify individuals with insulin resistance. HOMA cutoff point for Tanner I and II boys was 3.2, for Tanner I and II girls was 4.1, for Tanner III and IV boys was 4.2 and for Tanner III and IV girls was 5.0.
BACKGROUND: Plasma insulin and HOMA (homeostasis model assessment) index, used to determine insulin resistance, do not have local standard values for children and adolescents in Chile. AIM: To establish the normal reference intervals for insulin and HOMA in children and adolescents aged 10-15 years, according to sex and puberal maturation. MATERIAL AND METHODS: A cross-sectional study of 2,153 children and adolescents from Puente Alto County was performed, during 2009 and 2010. Anthropometry and self-report of puberal maturation were assessed. Fasting glucose (hexoquinase) and insulin blood levels (chemiluminiscence), were determined and HOMA index was calculated. Percentile distributions of these variables were calculated. RESULTS: The reference group included only subjects with normal body mass index and fasting blood glucose (n = 1,192). Girls had higher insulin and HOMA values than boys (12.5 ± 6.0 and 9.1 ± 4.9 μϋ/mL (p < 0.01) and 2.7 ± 1.4 and 2.1 ± 1,1 (p < 0.01), respectively). Subjects with Tanner I and II pubertal stages had lower insulin and HOMA mean values than subjects with Tanner III and IV (9.0 ± 4.3 and 12.5 ± 6.2μϋ/ml (p < 0.01) and2.0 ± 1 and2.8 ± 1.4 (p < 0.01), respectively). CONCLUSIONS: The 90th percentile of insulin and HOMA distributions according to sex and maturation, was selected as the upper cut-off point to identify individuals with insulin resistance. HOMA cutoff point for Tanner I and II boys was 3.2, for Tanner I and II girls was 4.1, for Tanner III and IV boys was 4.2 and for Tanner III and IV girls was 5.0.
Authors: J Peplies; D Jiménez-Pavón; S C Savva; C Buck; K Günther; A Fraterman; P Russo; L Iacoviello; T Veidebaum; M Tornaritis; S De Henauw; S Mårild; D Molnár; L A Moreno; W Ahrens Journal: Int J Obes (Lond) Date: 2014-09 Impact factor: 5.095
Authors: Francisco Mardones; Pilar Arnaiz; Paz Pacheco; Angelica Dominguez; Luis Villarroel; Johan G Eriksson; Salesa Barja; Marcelo Farías; Oscar Castillo Journal: Biomed Res Int Date: 2014-06-15 Impact factor: 3.411
Authors: Edith Cardenas-Vargas; Jairo A Nava; Idalia Garza-Veloz; Mayra C Torres-Castañeda; Carlos E Galván-Tejada; Miguel A Cid-Baez; Rosa E Castañeda-Arteaga; Yolanda Ortiz-Castro; Perla M Trejo-Ortiz; Roxana Araujo-Espino; Fabiana E Mollinedo-Montaño; Jose R Muñoz-Torres; Margarita L Martinez-Fierro Journal: Int J Endocrinol Date: 2018-09-03 Impact factor: 3.257