Literature DB >> 22446523

The next phase of life-sciences spaceflight research: Harnessing the power of functional genomics.

Timothy Etheridge, Kanako Nemoto, Toko Hashizume, Chihiro Mori, Tomoko Sugimoto, Hiromi Suzuki, Keiji Fukui, Takashi Yamazaki, Akira Higashibata, Nathaniel J Szewczyk, Atsushi Higashitani.   

Abstract

Recently we demonstrated that the effectiveness of RNAi interference (RNAi) for inhibiting gene expression is maintained during spaceflight in the worm Caenorhabditis elegans and argued for the biomedical importance of this finding. We also successfully utilized green fluorescent protein (GFP)-tagged proteins to monitor changes in GPF localization during flight. Here we discuss potential applications of RNAi and GFP in spaceflight studies and the ramifications of these experiments for the future of space life-sciences research.

Entities:  

Year:  2011        PMID： 22446523      PMCID： PMC3306327          DOI： 10.4161/cib.16975

Source DB:  PubMed          Journal:  Commun Integr Biol        ISSN： 1942-0889


  12 in total

1.  Development and chromosome mechanics in nematodes: results from IML-1.

Authors:  G A Nelson; W W Schubert; G A Kazarians; G F Richards
Journal:  Adv Space Res       Date:  1994       Impact factor: 2.152

2.  Radiation effects in nematodes: results from IML-1 experiments.

Authors:  G A Nelson; W W Schubert; G A Kazarians; G F Richards; E V Benton; E R Benton; R Henke
Journal:  Adv Space Res       Date:  1994-10       Impact factor: 2.152

3.  Caenorhabditis elegans survives atmospheric breakup of STS-107, space shuttle Columbia.

Authors:  Nathaniel J Szewczyk; Rocco L Mancinelli; William McLamb; David Reed; Baruch S Blumberg; Catharine A Conley
Journal:  Astrobiology       Date:  2005-12       Impact factor: 4.335

4.  Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans.

Authors:  Nahui Kim; Catherine M Dempsey; Chih-Jen Kuan; Jim V Zoval; Eyleen O'Rourke; Gary Ruvkun; Marc J Madou; Ji Y Sze
Journal:  Genetics       Date:  2007-08-24       Impact factor: 4.562

5.  Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.

Authors:  A Fire; S Xu; M K Montgomery; S A Kostas; S E Driver; C C Mello
Journal:  Nature       Date:  1998-02-19       Impact factor: 49.962

6.  Decreased expression of myogenic transcription factors and myosin heavy chains in Caenorhabditis elegans muscles developed during spaceflight.

Authors:  Akira Higashibata; Nathaniel J Szewczyk; Catharine A Conley; Mari Imamizo-Sato; Atsushi Higashitani; Noriaki Ishioka
Journal:  J Exp Biol       Date:  2006-08       Impact factor: 3.312

7.  Green fluorescent protein as a marker for gene expression.

Authors:  M Chalfie; Y Tu; G Euskirchen; W W Ward; D C Prasher
Journal:  Science       Date:  1994-02-11       Impact factor: 47.728

8.  Whole-animal high-throughput screens: the C. elegans model.

Authors:  Eyleen J O'Rourke; Annie L Conery; Terence I Moy
Journal:  Methods Mol Biol       Date:  2009

9.  Genomic response of the nematode Caenorhabditis elegans to spaceflight.

Authors:  Florian Selch; Akira Higashibata; Mari Imamizo-Sato; Atsushi Higashitani; Noriaki Ishioka; Nathaniel J Szewczyk; Catharine A Conley
Journal:  Adv Space Res       Date:  2008       Impact factor: 2.152

10.  The effectiveness of RNAi in Caenorhabditis elegans is maintained during spaceflight.

Authors:  Timothy Etheridge; Kanako Nemoto; Toko Hashizume; Chihiro Mori; Tomoko Sugimoto; Hiromi Suzuki; Keiji Fukui; Takashi Yamazaki; Akira Higashibata; Nathaniel J Szewczyk; Atsushi Higashitani
Journal:  PLoS One       Date:  2011-06-01       Impact factor: 3.240
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  1 in total

1.  Evaluation of the Fluids Mixing Enclosure System for Life Science Experiments During a Commercial Caenorhabditis elegans Spaceflight Experiment.

Authors:  Paul Warren; Andy Golden; John Hanover; Dona Love; Freya Shephard; Nathaniel J Szewczyk
Journal:  Adv Space Res       Date:  2013-06-01       Impact factor: 2.152
  1 in total

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