Literature DB >> 22446076

Investigation of chronic alcohol consumption in rodents via ultra-high-performance liquid chromatography-mass spectrometry based metabolite profiling.

Helen G Gika1, Cheng Ji, Georgios A Theodoridis, Filippos Michopoulos, Neil Kaplowitz, Ian D Wilson.   

Abstract

Alcohol consumption in man, when seen in its extreme form of alcoholism, is a complex and socially disruptive disorder that can result in significant levels of liver injury. Here the rodent "intragastric feeding model" was used together with UHPLC-TOFMS analysis to determine changes in global metabolite profiles for plasma and urine from alcohol treated rats and mice compared to control animals. Multivariate statistical analysis (using principal components analysis, PCA) revealed robust differences between profiles from control and alcohol-treated animals from both species. A large number of metabolites were seen to differ between control and alcohol-treated animals, for both biofluids.
Copyright © 2012 Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 22446076      PMCID： PMC3387526          DOI： 10.1016/j.chroma.2012.02.053

Source DB:  PubMed          Journal:  J Chromatogr A        ISSN： 0021-9673            Impact factor:   4.759


  21 in total

1.  The effects of ethanol on tryptophan pyrrolase activity and their comparison with those of phenobarbitone and morphine.

Authors:  A A Badawy; M Evans
Journal:  Adv Exp Med Biol       Date:  1975       Impact factor: 2.622

2.  Evaluation of the repeatability of ultra-performance liquid chromatography-TOF-MS for global metabolic profiling of human urine samples.

Authors:  Helen G Gika; Euan Macpherson; Georgios A Theodoridis; Ian D Wilson
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2008-06-06       Impact factor: 3.205

3.  Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse.

Authors:  Soumen K Manna; Andrew D Patterson; Qian Yang; Kristopher W Krausz; Henghong Li; Jeffrey R Idle; Albert J Fornace; Frank J Gonzalez
Journal:  J Proteome Res       Date:  2010-08-06       Impact factor: 4.466

4.  HILIC-UPLC-MS for exploratory urinary metabolic profiling in toxicological studies.

Authors:  Konstantina Spagou; Ian D Wilson; Perrine Masson; Georgios Theodoridis; Nikolaos Raikos; Muireann Coen; Elaine Holmes; John C Lindon; Robert S Plumb; Jeremy K Nicholson; Elizabeth J Want
Journal:  Anal Chem       Date:  2010-12-13       Impact factor: 6.986

5.  Does the mass spectrometer define the marker? A comparison of global metabolite profiling data generated simultaneously via UPLC-MS on two different mass spectrometers.

Authors:  Helen G Gika; Georgios A Theodoridis; Mark Earll; Rodney W Snyder; Susan J Sumner; Ian D Wilson
Journal:  Anal Chem       Date:  2010-10-01       Impact factor: 6.986

Review 6.  Update of the LIPID MAPS comprehensive classification system for lipids.

Authors:  Eoin Fahy; Shankar Subramaniam; Robert C Murphy; Masahiro Nishijima; Christian R H Raetz; Takao Shimizu; Friedrich Spener; Gerrit van Meer; Michael J O Wakelam; Edward A Dennis
Journal:  J Lipid Res       Date:  2008-12-19       Impact factor: 5.922

7.  Tryptophan metabolism in alcoholism.

Authors:  Abdulla A-B Badawy
Journal:  Nutr Res Rev       Date:  2002-06       Impact factor: 7.800

8.  1H NMR-based metabolomic analysis of liver, serum, and brain following ethanol administration in rats.

Authors:  Peter C Nicholas; Daniel Kim; Fulton T Crews; Jeffrey M Macdonald
Journal:  Chem Res Toxicol       Date:  2007-12-21       Impact factor: 3.739

Review 9.  ESBRA 1994 Award Lecture. Phosphatidylethanol formation: specific effects of ethanol mediated via phospholipase D.

Authors:  L Gustavsson
Journal:  Alcohol Alcohol       Date:  1995-07       Impact factor: 2.826

10.  HMDB: the Human Metabolome Database.

Authors:  David S Wishart; Dan Tzur; Craig Knox; Roman Eisner; An Chi Guo; Nelson Young; Dean Cheng; Kevin Jewell; David Arndt; Summit Sawhney; Chris Fung; Lisa Nikolai; Mike Lewis; Marie-Aude Coutouly; Ian Forsythe; Peter Tang; Savita Shrivastava; Kevin Jeroncic; Paul Stothard; Godwin Amegbey; David Block; David D Hau; James Wagner; Jessica Miniaci; Melisa Clements; Mulu Gebremedhin; Natalie Guo; Ying Zhang; Gavin E Duggan; Glen D Macinnis; Alim M Weljie; Reza Dowlatabadi; Fiona Bamforth; Derrick Clive; Russ Greiner; Liang Li; Tom Marrie; Brian D Sykes; Hans J Vogel; Lori Querengesser
Journal:  Nucleic Acids Res       Date:  2007-01       Impact factor: 16.971
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  10 in total

Review 1.  The Hepatic Lipidome: A Gateway to Understanding the Pathogenes is of Alcohol-Induced Fatty Liver.

Authors:  Robin D Clugston; Madeleine A Gao; William S Blaner
Journal:  Curr Mol Pharmacol       Date:  2017       Impact factor: 3.339

2.  Dietary fat sources differentially modulate intestinal barrier and hepatic inflammation in alcohol-induced liver injury in rats.

Authors:  Wei Zhong; Qiong Li; Guoxiang Xie; Xiuhua Sun; Xiaobing Tan; Xinguo Sun; Wei Jia; Zhanxiang Zhou
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2013-10-10       Impact factor: 4.052

3.  Glutathione deficiency-elicited reprogramming of hepatic metabolism protects against alcohol-induced steatosis.

Authors:  Ying Chen; Soumen K Manna; Srujana Golla; Kristopher W Krausz; Yan Cai; Rolando Garcia-Milian; Tanushree Chakraborty; Joyeeta Chakraborty; Raghunath Chatterjee; David C Thompson; Frank J Gonzalez; Vasilis Vasiliou
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4.  The neurometabolic fingerprint of excessive alcohol drinking.

Authors:  Marcus W Meinhardt; Daniel C Sévin; Manuela L Klee; Sandra Dieter; Uwe Sauer; Wolfgang H Sommer
Journal:  Neuropsychopharmacology       Date:  2015-03-13       Impact factor: 7.853

Review 5.  Development of blood biomarkers for drug-induced liver injury: an evaluation of their potential for risk assessment and diagnostics.

Authors:  David E Amacher; Shelli J Schomaker; Jiri Aubrecht
Journal:  Mol Diagn Ther       Date:  2013-12       Impact factor: 4.074

6.  Application of Q-TOF-MS based metabonomics techniques to analyze the plasma metabolic profile changes on rats following death due to acute intoxication of phorate.

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Journal:  Int J Legal Med       Date:  2021-05-13       Impact factor: 2.686

7.  The 1H-NMR-based metabolite profile of acute alcohol consumption: A metabolomics intervention study.

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Journal:  PLoS One       Date:  2018-05-10       Impact factor: 3.240

8.  Chronic alcohol ingestion increases mortality and organ injury in a murine model of septic peritonitis.

Authors:  Benyam P Yoseph; Elise Breed; Christian E Overgaard; Christina J Ward; Zhe Liang; Maylene E Wagener; Daniel R Lexcen; Elizabeth R Lusczek; Greg J Beilman; Eileen M Burd; Alton B Farris; David M Guidot; Michael Koval; Mandy L Ford; Craig M Coopersmith
Journal:  PLoS One       Date:  2013-05-22       Impact factor: 3.240

9.  GC-MS-based urinary organic acid profiling reveals multiple dysregulated metabolic pathways following experimental acute alcohol consumption.

Authors:  Cindy Irwin; Lodewyk J Mienie; Ron A Wevers; Shayne Mason; Johan A Westerhuis; Mari van Reenen; Carolus J Reinecke
Journal:  Sci Rep       Date:  2018-04-10       Impact factor: 4.379

10.  Study of Fecal and Urinary Metabolite Perturbations Induced by Chronic Ethanol Treatment in Mice by UHPLC-MS/MS Targeted Profiling.

Authors:  Olga Deda; Christina Virgiliou; Amvrosios Orfanidis; Helen G Gika
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  10 in total

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