| Literature DB >> 22445740 |
Crystal Wheeler1, L Burt Nabors, Scott Barnum, Xiuhua Yang, Xianzhen Hu, Trenton R Schoeb, Dongquan Chen, Agnieszka A Ardelt, Peter H King.
Abstract
In experimental autoimmune encephalomyelitis (EAE) and other neurodegenerative diseases, astrocytes play an important role in promoting or attenuating the inflammatory response through induction of different cytokines and growth factors. HuR plays a major role in regulating many of these factors by modulating RNA stability and translational efficiency. Here, we engineered transgenic mice to express HuR in astrocytes using the human glial fibrillary acidic protein promoter and found that female transgenic mice had significantly less clinical disability and histopathological changes in the spinal cord. Ovariectomy prior to EAE induction abrogated the protective effect. Our findings support a role for the astrocyte and posttranscriptional regulation in hormonally-mediated attenuation of EAE. Published by Elsevier B.V.Entities:
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Year: 2012 PMID： 22445740 PMCID： PMC3335935 DOI： 10.1016/j.jneuroim.2012.02.014
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478