Literature DB >> 11289308

HuR and mRNA stability.

C M Brennan1, J A Steitz.   

Abstract

An important mechanism of posttranscriptional gene regulation in mammalian cells is the rapid degradation of messenger RNAs (mRNAs) signaled by AU-rich elements (AREs) in their 3' untranslated regions. HuR, a ubiquitously expressed member of the Hu family of RNA-binding proteins related to Drosophila ELAV, selectively binds AREs and stabilizes ARE-containing mRNAs when overexpressed in cultured cells. This review discusses mRNA decay as a general form of gene regulation, decay signaled by AREs, and the role of HuR and its Hu-family relatives in antagonizing this mRNA degradation pathway. The influence of newly identified protein ligands to HuR on HuR function in both normal and stressed cells may explain how ARE-mediated mRNA decay is regulated in response to environmental change.

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Year:  2001        PMID： 11289308     DOI： 10.1007/PL00000854

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  476 in total

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Journal:  Mol Neurobiol       Date:  2002-04       Impact factor: 5.590

2.  Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock.

Authors:  I E Gallouzi; C M Brennan; J A Steitz
Journal:  RNA       Date:  2001-09       Impact factor: 4.942

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5.  ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR.

Authors:  Michael Kullmann; Ulrich Göpfert; Basile Siewe; Ludger Hengst
Journal:  Genes Dev       Date:  2002-12-01       Impact factor: 11.361

Review 6.  MRNA stability and the control of gene expression: implications for human disease.

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Journal:  Neurochem Res       Date:  2002-10       Impact factor: 3.996

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Review 8.  Translating the Untranslated Region.

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9.  The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells.

Authors:  F F Blanco; M Jimbo; J Wulfkuhle; I Gallagher; J Deng; L Enyenihi; N Meisner-Kober; E Londin; I Rigoutsos; J A Sawicki; M V Risbud; A K Witkiewicz; P A McCue; W Jiang; H Rui; C J Yeo; E Petricoin; J M Winter; J R Brody
Journal:  Oncogene       Date:  2015-09-21       Impact factor: 9.867

10.  Genome-wide screening identifies oncofetal lncRNA Ptn-dt promoting the proliferation of hepatocellular carcinoma cells by regulating the Ptn receptor.

Authors:  Jin-Feng Huang; Hong-Yue Jiang; Hui Cai; Yan Liu; Yi-Qing Zhu; Sha-Sha Lin; Ting-Ting Hu; Tian-Tian Wang; Wen-Jun Yang; Bang Xiao; Shu-Han Sun; Li-Ye Ma; Hui-Rong Yin; Fang Wang
Journal:  Oncogene       Date:  2019-01-14       Impact factor: 9.867
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