Zhiye Chen1, Feng Feng, Yang Yang, Jinfeng Li, Lin Ma. 1. Department of Radiology, PLA General Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 28 Fuxing Road, Beijing 100853, China. yyqf@hotmail.com
Abstract
PURPOSE: To evaluate MR imaging findings in corpus callosum region for the discrimination between opticospinal multiple sclerosis (OSMS) and neuromyelitis optica (NMO). MATERIALS AND METHODS: Forty-two definite OSMS with seronegative NMO-IgG and 23 NMO with seropositive NMO-IgG, and 27 age-matched normal controls (NC) were recruited. Sagittal T2-FLAIR images with 2-mm slice thickness were obtained. Subcallosal dot-dash (SCDD) sign and subcallosal striations (SCS) sign were reviewed. RESULTS: SCDD was more commonly detected in OSMS (28 of 42 patients) than in NMO (5 of 23 patients) (P<0.05). SCS showed no difference between OSMS (31 of 42 patients) and NMO (12 of 23 patients) (P>0.05). For comparing ROC analysis among SCDD, SCS, and SCDD+SCS for predicted probability through binary logistic regression analysis, SCDD+SCS had the largest area under ROC curve (0.777) than SCDD (0.725) and SCS (0.608). CONCLUSION: SCDD may be helpful in distinguishing OSMS from NMO. The regression equation may also be a simple and effective method of choice for the differentiation between OSMS and NMO.
PURPOSE: To evaluate MR imaging findings in corpus callosum region for the discrimination between opticospinal multiple sclerosis (OSMS) and neuromyelitis optica (NMO). MATERIALS AND METHODS: Forty-two definite OSMS with seronegative NMO-IgG and 23 NMO with seropositive NMO-IgG, and 27 age-matched normal controls (NC) were recruited. Sagittal T2-FLAIR images with 2-mm slice thickness were obtained. Subcallosal dot-dash (SCDD) sign and subcallosal striations (SCS) sign were reviewed. RESULTS:SCDD was more commonly detected in OSMS (28 of 42 patients) than in NMO (5 of 23 patients) (P<0.05). SCS showed no difference between OSMS (31 of 42 patients) and NMO (12 of 23 patients) (P>0.05). For comparing ROC analysis among SCDD, SCS, and SCDD+SCS for predicted probability through binary logistic regression analysis, SCDD+SCS had the largest area under ROC curve (0.777) than SCDD (0.725) and SCS (0.608). CONCLUSION:SCDD may be helpful in distinguishing OSMS from NMO. The regression equation may also be a simple and effective method of choice for the differentiation between OSMS and NMO.