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Literature DB >> 22444585

We see the light: chemical-genetic protein regulation.

Abstract

The challenge of studying complex protein networks in whole animals has driven the development of new methods for manipulating protein function with spatial and temporal precision. A novel combination of chemical and genetic protein regulation (Rodriguez and Wolfgang, in this issue of Chemistry & Biology) achieves levels of control that will revolutionize the study of protein function. Copyright Â

Entities: Chemical Gene Species

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Year: 2012 PMID： 22444585 PMCID： PMC5827985 DOI： 10.1016/j.chembiol.2012.03.001

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

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References

8 in total

1. Investigating protein-ligand interactions with a mutant FKBP possessing a designed specificity pocket.

Authors: W Yang; L W Rozamus; S Narula; C T Rollins; R Yuan; L J Andrade; M K Ram; T B Phillips; M R van Schravendijk; D Dalgarno; T Clackson; D A Holt
Journal: J Med Chem Date: 2000-03-23 Impact factor: 7.446

2. Targeted chemical-genetic regulation of protein stability in vivo.

Authors: Susana Rodriguez; Michael J Wolfgang
Journal: Chem Biol Date: 2012-03-23

3. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.

Authors: K R Thomas; M R Capecchi
Journal: Nature Date: 1990-08-30 Impact factor: 49.962

We see the light: chemical-genetic protein regulation.

1. Investigating protein-ligand interactions with a mutant FKBP possessing a designed specificity pocket.

2. Targeted chemical-genetic regulation of protein stability in vivo.

3. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.

4. A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules.

5. Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells.

6. Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector.

7. Transcriptional activation by tetracyclines in mammalian cells.

8. Conditional protein alleles using knockin mice and a chemical inducer of dimerization.