INTRODUCTION: The incidence of symptomatic catheter-related deep vein thrombosis (DVT) in cancer patients remains unclear and there is a lack of reliable data on the risk factors of PICC-related DVT. MATERIALS AND METHODS: We performed a retrospective cohort study of consecutive cancer patients who received an ultrasound guided PICC line for the administration of chemotherapy. Univariable and multivariable logistic regression analyses were performed to identify risk factors for symptomatic PICC-related DVT. RESULTS: In total, 340 cancer patients obtained PICC lines for the administration of chemotherapy. Of these patients, 19 (5.6%; 95% CI: 3.6-8.6) developed symptomatic PICC-related DVT. Factors previously associated with catheter-related DVT, including side of catheter placement, lumen size, tip location, need for repositioning, and number of insertion attempts, were not significant determinants in our analysis. Patients with diabetes were three times more likely to develop PICC-related DVT (OR 3.0, p=0.039), while the presence of COPD and metastatic cancer also increased the odds (OR 3.3, p=0.078 and OR 2.3, p=0.083 respectively). Diabetes remained a significant risk factor after adjustment for effect of metastases and COPD (OR 3.175, p=0.039). Further, the presence of metastases was a significant predictor (OR 3.34, p=0.024) in our multivariable model. CONCLUSIONS: Symptomatic PICC-related DVT are frequent in cancer patients receiving chemotherapy. Previously described factors associated with catheter-related thrombosis were not predictive of PICC-related DVT in our study. Diabetes, advanced disease and COPD appear to increase the risk of developing PICC-related DVT in chemotherapy patients.
INTRODUCTION: The incidence of symptomatic catheter-related deep vein thrombosis (DVT) in cancerpatients remains unclear and there is a lack of reliable data on the risk factors of PICC-related DVT. MATERIALS AND METHODS: We performed a retrospective cohort study of consecutive cancerpatients who received an ultrasound guided PICC line for the administration of chemotherapy. Univariable and multivariable logistic regression analyses were performed to identify risk factors for symptomatic PICC-related DVT. RESULTS: In total, 340 cancerpatients obtained PICC lines for the administration of chemotherapy. Of these patients, 19 (5.6%; 95% CI: 3.6-8.6) developed symptomatic PICC-related DVT. Factors previously associated with catheter-related DVT, including side of catheter placement, lumen size, tip location, need for repositioning, and number of insertion attempts, were not significant determinants in our analysis. Patients with diabetes were three times more likely to develop PICC-related DVT (OR 3.0, p=0.039), while the presence of COPD and metastatic cancer also increased the odds (OR 3.3, p=0.078 and OR 2.3, p=0.083 respectively). Diabetes remained a significant risk factor after adjustment for effect of metastases and COPD (OR 3.175, p=0.039). Further, the presence of metastases was a significant predictor (OR 3.34, p=0.024) in our multivariable model. CONCLUSIONS: Symptomatic PICC-related DVT are frequent in cancerpatients receiving chemotherapy. Previously described factors associated with catheter-related thrombosis were not predictive of PICC-related DVT in our study. Diabetes, advanced disease and COPD appear to increase the risk of developing PICC-related DVT in chemotherapy patients.
Authors: Natalia Curto-García; Julio García-Suárez; Marta Callejas Chavarria; Juan José Gil Fernández; Yolanda Martín Guerrero; Elena Magro Mazo; Shelly Marcellini Antonio; Luis Miguel Juárez; Isabel Gutierrez; Juan José Arranz; Irene Montalvo; Carmen Elvira; Pilar Domínguez; María Teresa Díaz; Carmen Burgaleta Journal: Support Care Cancer Date: 2015-05-03 Impact factor: 3.603
Authors: N LeVasseur; C Stober; K Daigle; A Robinson; S McDiarmid; S Mazzarello; B Hutton; A Joy; D Fergusson; J Hilton; M McInnes; M Clemons Journal: Curr Oncol Date: 2018-08-14 Impact factor: 3.677
Authors: N LeVasseur; C Stober; M Ibrahim; S Gertler; J Hilton; A Robinson; S McDiarmid; D Fergusson; S Mazzarello; B Hutton; A A Joy; M McInnes; M Clemons Journal: Curr Oncol Date: 2018-08-14 Impact factor: 3.677
Authors: Ralph Gnannt; Nicolas Waespe; Michael Temple; Afsaneh Amirabadi; Kuan Liu; Leonardo R Brandão; Bairbre L Connolly Journal: Pediatr Radiol Date: 2018-02-27
Authors: Sheryl McDiarmid; Nicholas Scrivens; Marc Carrier; Elham Sabri; Baldwin Toye; Lothar Huebsch; Dean Fergusson Journal: CMAJ Open Date: 2017-06-30